• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation of rabies infection risk for the population having habitat of dog-meat eating in southeast Asian countries

Research Project

Project/Area Number 16H05833
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene and public health
Research InstitutionOita University

Principal Investigator

Nishizono Akira  大分大学, 医学部, 教授 (70218155)

Co-Investigator(Kenkyū-buntansha) アハメド カムルディン  大分大学, 医学部, 客員研究員 (00398140)
齊藤 信夫  大分大学, 医学部, 助教 (60626018)
山田 健太郎  大分大学, 医学部, 准教授 (70458280)
鈴木 基  長崎大学, 熱帯医学研究所, 准教授 (60444874)
Research Collaborator Nguyen Kieu Anh  NIHE
Pakamatz Khawplod  タイ国赤十字病院
Elizabeth Miranda M.  フィリピン熱帯医学研究所
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords狂犬病 / アジア / 中和抗体 / ワクチン / 食習慣 / 東南アジア / 不顕性感染 / イヌ
Outline of Final Research Achievements

Culture of dog meat eating is special habitat existing in southeastern Asian countries but the risk of rabies infection associated with the handling of infected dogs and their meat is assumed, but the actual situation is not known at all. In a three-year plan, we analyzed risk factors for possible atypical rabies exposure from dog meat handling in Vietnam and the Philippines. As a result, it became clear that an atypical infection mode to infect a rabies virus by eating or treating the infected-dog meat without depending on an animal bite in these countries. Especially in the dog meat market workers in Vietnam, despite having no history of bite exposure from dogs and no history of rabies vaccination, they have antibodies against rabies virus and a latent or subclinical infection was considered to be established by the exposure to a small amount of virus.

Academic Significance and Societal Importance of the Research Achievements

東南アジアの国には動物咬傷に依らずイヌ肉を取り扱うことで、狂犬病ウイルスが感染するような非定型的感染ルートの存在が明らかになったことで、イヌ肉摂取の危険性について住民に周知させる必要があると考えられた。今回の国際共同研究が基盤となり、フィリピン熱帯医学研究所との間で平成30年度SATREPS事業が採択された。ここでは現行の狂犬病発生動向調査に、途上国で適応可能な迅速・簡便診断法を加えた動物の狂犬病確定検査法の有用性を検証し、医-獣連携ワンヘルスによる国内全土にわたる狂犬病コントロールシステムの基盤強化と情報共有基盤を構築するという、社会実装を目指した取り組みにつなげることができた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (27 results)

All 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Open Access: 5 results,  Peer Reviewed: 6 results,  Acknowledgement Compliant: 2 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (2 results)

  • [Int'l Joint Research] 国立衛生疫学研究所/ハノイ市予防医療センター(ベトナム)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 熱帯医学研究所/国立サンラザロ病院(フィリピン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] タイ赤十字協会(タイ)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A novel approach to quickly, easily and efficiently determine viral neutralising antibody (VNA) levels - for the elimination of rabies from South Eastern endemic countries2018

    • Author(s)
      Nishizono Akira
    • Journal Title

      Impact

      Volume: 2018 (7) Issue: 7 Pages: 39-41

    • DOI

      10.21820/23987073.2018.7.39

    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] Rabies Vaccine Hesitancy and Deaths Among Pregnant and Breastfeeding Women - Vietnam, 2015-2016.2018

    • Author(s)
      Nguyen ANK, et al
    • Journal Title

      MMWR Morbility Mortal Weekly Report

      Volume: 67 Issue: 8 Pages: 250-252

    • DOI

      10.15585/mmwr.mm6708a4

    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] Near-infrared fluorescent protein iRFP720 is optimal for in vivo fluorescence imaging of rabies virus infection2017

    • Author(s)
      Isomura Minori、Yamada Kentaro、Noguchi Kazuko、Nishizono Akira
    • Journal Title

      Journal of General Virology

      Volume: 98 Issue: 11 Pages: 2689-2698

    • DOI

      10.1099/jgv.0.000950

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathological lesions in the central nervous system and peripheral tissues of <i>dd</i>Y mice with street rabies virus (1088 strain)2017

    • Author(s)
      Kimitsuki, K., Yamada, Y., Shiwa, N., Inoue, S. and Park, CH.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 79 Issue: 6 Pages: 970-978

    • DOI

      10.1292/jvms.17-0028

    • NAID

      130005695725

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contribution of the interaction between the rabies virus P protein and I-kappa B kinase e; to the inhibition of type I IFN induction signalling.2016

    • Author(s)
      Masatani T, Ozawa M, Yamada K, Ito N, Horie M, Matsuu A, Okuya K, Tsukiyama-Kohara K, Sugiyama M, Nishizono A.
    • Journal Title

      J Gen Virol.

      Volume: 97 Issue: 2 Pages: 316-326

    • DOI

      10.1099/jgv.0.000362

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Efficacy of Favipiravir (T-705) in Rabies Post-exposure Prophylaxis.2016

    • Author(s)
      Kentaro Yamada et al
    • Journal Title

      The Journal of Infectious Diseases

      Volume: 213 Issue: 8 Pages: 1253-1261

    • DOI

      10.1093/infdis/jiv586

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased pathogenicity of rabies virus due to modification of a non- coding region.2016

    • Author(s)
      P. Virojanapirom et al.
    • Journal Title

      Archives of Virology

      Volume: 161 (11) Issue: 11 Pages: 3255-3261

    • DOI

      10.1007/s00705-016-2990-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Comparative Study of the RAPINA and the Virus-Neutralizing Test (RFFIT) for the Extimation of Antirabies-Neutralizing Antibody Levels in Dog Samples.2016

    • Author(s)
      DL Manalo et al.
    • Journal Title

      Zoonoses and Public Health

      Volume: 印刷中 Issue: 5 Pages: 355-362

    • DOI

      10.1111/zph.12313

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Favipiravir effect against rabies infection2018

    • Author(s)
      Nishizono Akira
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Establishment and application of in vivo bioluminescence imaging of rabies virus infection2018

    • Author(s)
      Yamada Kentaro et. al.
    • Organizer
      66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] in vivoイメージングによるファビピラビルの狂犬病ウイルス感染に対する効果の評価2018

    • Author(s)
      山田健太郎 他
    • Organizer
      第55回日本ウイルス学会九州支部総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 近赤外蛍光蛋白質は狂犬病ウイルス感染のin vino蛍光イメージング解析に適する2017

    • Author(s)
      山田 健太郎 他
    • Organizer
      第16回狂犬病研究会プログラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 近赤外蛍光蛋白質iRFP720は狂犬病ウイルスのin vivoイメージング解析に適する2017

    • Author(s)
      山田 健太郎 他
    • Organizer
      第70回日本細菌学会九州支部総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 近赤外蛍光蛋白質iRFP720は狂犬病ウイルスのin vivoイメージング解析に適する2017

    • Author(s)
      山田 健太郎 他
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フィリピン国立感染症病院に入院した狂犬病患者の臨床的特徴の検討2017

    • Author(s)
      齊藤 信夫 他
    • Organizer
      第58回日本熱帯医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Near-infrared fluorescent protein IRFP720 is optimal for in vivo fluorescence imaging of rabies virus infection2017

    • Author(s)
      Kentaro Yamada et al.
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 狂犬病についての最新の話題2017

    • Author(s)
      西園 晃
    • Organizer
      第17回人と動物の共通感染症研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 赤色蛍光蛋白質E2-Crimson発現組換え狂犬病ウイルス街上毒の作出とin vivoイメージング解析2016

    • Author(s)
      Kentaro Yamada et al.
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] In vivo蛍光イメージング解析に資する赤色蛍光蛋白質E2-Crimson発現組換え狂犬病ウイルス街上毒株の作出2016

    • Author(s)
      磯村 美乃里 他
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学湘南キャンパス(神奈川県・藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 狂犬病ウイルス感染のin vivo蛍光イメージング解析2016

    • Author(s)
      山田 健太郎 他
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学湘南キャンパス(神奈川県・藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 渡航医学の視点からみた「不治の感染症 狂犬病」2016

    • Author(s)
      西園 晃 他
    • Organizer
      第20会日本渡航医学会学術集会
    • Place of Presentation
      倉敷芸文館(岡山県・倉敷市)
    • Year and Date
      2016-07-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 狂犬病~この古くて忘れ去られたしの感染症~これまでとこれから2016

    • Author(s)
      西園 晃 他
    • Organizer
      第90回日本感染症学会総会・学術講演会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Remarks] 大分大学医学部微生物学

    • URL

      http://www.med.oita-u.ac.jp/biseibut/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 大分大学医学部微生物学

    • URL

      http://www.med.oita-u.ac.jp/biseibut/home.html/home.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi