| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
The striatum is one of the input nuclei of the basal ganglia and supposed to regulate voluntary movements. Striatal projection neurons receive information by neurotransmitters which are released from the other nuclei of the basal ganglia. After receive the neurotransmitter, signal molecules in the striatum are activated and striatal projection neurons send the information to other brain regions. To clarify the relation between activity of the signal molecule, neuronal activity of the basal ganglia and voluntary movements, we used gene transfer technique to express the dominant active form of the signal molecule in the striatum and recorded behavioral changes and neuronal activities. The dominant active form of the signal molecule in the striatum increased information flow from the striatum and facilitated voluntary movements.
|
