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Study on the prevention of a pandemic outbreak of high virulence influenza using engineering vaccine

Research Project

Project/Area Number 16K06079
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Fluid engineering
Research InstitutionKyoto Institute of Technology

Principal Investigator

Yamakawa Masashi  京都工芸繊維大学, 機械工学系, 准教授 (90346114)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywordsインフルエンザウイルス / 流体力学 / 数値流体力学 / ウイルス / シミュレーション工学 / 感染
Outline of Final Research Achievements

To prevent the damage in outbreak of high virulence influenza, on droplet nuclei infection as main route of the infection, finding its mechanism and prevention were studied. It was investigated from the point of view of fluid dynamics. Using airflow computation with parameters of virus and its environment based on virology, behaviour of influenza virus was calculated in a high accuracy. In the case of computation for flows in an indoor environment, unstructured mesh system was adopted to express a detail shape of human. Then, delicate flow changes with sneezing and coughing were computed using active boundary conditions. In the case of flows in respiratory tract, a motion of breathe with lungs were expressed using the moving grid method to specify viral landing points. Furthermore, we tried to develope the fluid dynamics engineering vaccine to prevent the infection by controlling an airflow. Also, a consecutive calculation among indoor and respiratory tract is nearly completed.

Academic Significance and Societal Importance of the Research Achievements

本研究は人類の脅威である鳥インフルエンザパンデミックに対し,予防策を工学的な観点から追究したものであり,特定の期間では医薬分野以上にその効果が期待できるものである.またインフルエンザに限定されない幅広いウイルス感染やまた放射能の拡散等にも応用できるものとなっている.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (25 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (15 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 15 results,  Open Access: 12 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 6 results)

  • [Int'l Joint Research] University of Warwick(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Warwick(英国)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Numerical Analysis of Free Surface Flow with Multiple Moving Fish along a Curved Path2019

    • Author(s)
      石原定典,山川勝史,井ノ本健,浅尾慎一
    • Journal Title

      Transactions of the Japan Society for Computational Engineering and Science

      Volume: 2019 Issue: 0 Pages: 20190001-20190001

    • DOI

      10.11421/jsces.2019.20190001

    • NAID

      130007592121

    • ISSN
      1347-8826
    • Year and Date
      2019-02-08
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Plate Mounted between Two Wires in Electric Arc Spraying2019

    • Author(s)
      Ryoji Tamaki and Masashi Yamakawa
    • Journal Title

      Journal of Computational Science

      Volume: 32 Pages: 5667-5667

    • DOI

      10.1016/j.jocs.2019.02.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Free Surface Flow Simulation of Fish Turning Motion2018

    • Author(s)
      Sadanori Ishihara, Masashi Yamakawa, Takeshi Inomoto and Shinichi Asao
    • Journal Title

      Lecture Notes in Computer Science

      Volume: LNCS 10862 Pages: 2436-2436

    • DOI

      10.1007/978-3-319-93713-7_2

    • ISBN
      9783319937120, 9783319937137
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elucidation of Mechanism for Reducing Porosity in Electric Arc Spraying Through CFD2018

    • Author(s)
      Ryoji Tamaki and Masashi Yamakawa
    • Journal Title

      Lecture Notes in Computer Science

      Volume: LNCS 10860 Pages: 418428-418428

    • DOI

      10.1007/978-3-319-93698-7_32

    • ISBN
      9783319936970, 9783319936987
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unstructured Parallel Computing for Euler/Navier-Stokes Solver2018

    • Author(s)
      Masashi Yamakawa, Tomoya Ukai and Shinichi Asao
    • Journal Title

      The Proc. of 12th Asian Computational Fluid Dynamics Conference

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study on Moving Cuttlefish by Fin Motion and Fluid Flow Around It2018

    • Author(s)
      Shinichi Asao, Masashi Yamakawa and Yuto Mori
    • Journal Title

      The Proc. of 12th Asian Computational Fluid Dynamics Conference,

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parallel Free Surface Flow Simulation of Fish Turning Motion2018

    • Author(s)
      Sadanori Ishihara, Masashi Yamakawa, Takeshi Inomoto and Shinichi Asao
    • Journal Title

      The Proc. of 12th Asian Computational Fluid Dynamics Conference,

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influenza Viral Infection Simulation in Human Respiratory Tract2018

    • Author(s)
      Masashi Yamakawa, Hiroki Takemoto, Shinichi Asao and Yongmann M. Chung
    • Journal Title

      The Proc. of 29th International Symposium on Transport Phenomena

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elucidation of Jet Phenomena in Electric Arc Spraing through CFD and Schlieren System2018

    • Author(s)
      Ryoji Tamaki, Yasuaki Imai and Masashi Yamakawa
    • Journal Title

      The Proc. of 29th International Symposium on Transport Phenom

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Numerical Simulation of Rotation of Intermeshing Rotors using Added and Eliminated Mesh Method2018

    • Author(s)
      Masashi Yamakawa, Naoya Mitsunari and Shinichi Asao
    • Journal Title

      Procedia Computer Science

      Volume: 108C Pages: 1883-1892

    • DOI

      10.1016/j.procs.2017.05.061

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Numerical simulation of flow around human in underwater dolphin kick swimming2017

    • Author(s)
      水野徳人,山川勝史
    • Journal Title

      Transactions of the JSME (in Japanese)

      Volume: 83 Issue: 845 Pages: 16-00049-16-00049

    • DOI

      10.1299/transjsme.16-00049

    • NAID

      130005303742

    • ISSN
      2187-9761
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Numerical Simulation of Tilt-Rotor Plane using Multi Axes Sliding Mesh Approach2016

    • Author(s)
      M. Yamakawa, S. Chikaguchi and S. Asao
    • Journal Title

      The Proc. of 27th-ISTP

      Volume: 1 Pages: 1-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Numerical Simulation of Aircraft Model towards Digital Flight based on Unstructured Moving Computational Domain Method2016

    • Author(s)
      M. Nishimura, R. Sakashita, M. Yamakawa, K. Matsuno and S. Asao
    • Journal Title

      The Proc. of 27th-ISTP

      Volume: 1 Pages: 1-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Progresssive Development of Sliding Mesh Approach for Simulations of A Flow Around Moving Body2016

    • Author(s)
      S. Asao, M. Yamakawa, K. Matsuno and S.Ishihara
    • Journal Title

      The Proc. of 27th-ISTP

      Volume: 1 Pages: 1-5

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Study on the Nozzle Jet in Arc Spraying2016

    • Author(s)
      Ryoji, TAMAKI, Masashi YAMAKAWA
    • Journal Title

      Applied Mathematics and Mechanics

      Volume: 37(12) Pages: 1394-1402

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Unstructured Parallel Computing for Euler/Navier-Stokes Solver2018

    • Author(s)
      Masashi Yamakawa, Tomoya Ukai and Shinichi Asao
    • Organizer
      ACFD2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Study on Moving Cuttlefish by Fin Motion and Fluid Flow Around It2018

    • Author(s)
      Shinichi Asao, Masashi Yamakawa and Yuto Mori
    • Organizer
      ACFD2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Parallel Free Surface Flow Simulation of Fish Turning Motion2018

    • Author(s)
      Sadanori Ishihara, Masashi Yamakawa, Takeshi Inomoto and Shinichi Asao
    • Organizer
      ACFD2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Influenza Viral Infection Simulation in Human Respiratory Tract2018

    • Author(s)
      Masashi Yamakawa, Hiroki Takemoto, Shinichi Asao and Yongmann M. Chung
    • Organizer
      ISTP29
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidation of Jet Phenomena in Electric Arc Spraing through CFD and Schlieren System2018

    • Author(s)
      Ryoji Tamaki, Yasuaki Imai and Masashi Yamakawa
    • Organizer
      ISTP29
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ACCELERATION OF EULER/NAVIER-STOKES SOLVER WITH PARALLEL COMPUTATIONS2017

    • Author(s)
      Tomoya Ukai, Masashi Yamakawa, and Shinichi Asao
    • Organizer
      Parallel CFD 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高速で旋回走行するフォーミュラカー周りの解析2017

    • Author(s)
      宮岡伸行,山川勝史,浅尾慎一
    • Organizer
      第31回数値流体力学シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 自由表面流れ内に移動物体を有する数値シミュレーション2017

    • Author(s)
      棚橋昭夫,山川勝史,浅尾慎一
    • Organizer
      第31回数値流体力学シンポジウム
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-22  

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