Study on the resin glycosides for aimed to develop new medicine
| Project/Area Number |
16K08306
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Tokai University |
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Principal Investigator |
ONO Masateru 東海大学, 農学部, 教授 (60177269)
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| Co-Investigator(Kenkyū-buntansha) |
安田 伸 東海大学, 農学部, 教授 (10512923)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 樹脂配糖体 / サツマイモ / ハマヒルガオ / ハリアサガオ / ブラジルヤラッパ / ルコウアサガオ / マメアサガオ / コヒルガオ / ヒルガオ科 / ヒルガオ科植物 / ブラジルヤラッパ根 / 癌細胞増殖抑制活性 / コンボルブリン / ヤラピン / 薬学 / 糖鎖 / 脂質 / 分析科学 / 生理活性 |
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| Outline of Final Research Achievements |
Resin glycosides are oligoglycosides of hydroxyl fatty acids partially acylated by some organic acids at the sugar moiety and are characteristic of Convolvulaceae plants. The resin glycosides from seven Convolvulaceae plants including Ipomoea batatas (L.) Lam., Calystegia soldanella Roem. et Schult., I. muricata (L.) Jacq., I. operculata (Gomes) Mart., Quamoclit × multifida, I. lacunosa L., and C. hederacea Wall., were studied. As a result, 36 resin glycosides were obtained. Among them, the structures of 22 resin glycosides including 15 new ones were determined on the basis of spectroscopic data as well as chemical evidence. Additionally, among the structure-determined resin glycosides, one compounds revealed effect against the herpes simplex virus type one, and three compounds demonstrated cytotoxic activity toward HL-60 human leukemia cells.
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| Academic Significance and Societal Importance of the Research Achievements |
樹脂配糖体の研究の歴史は長いが、樹脂配糖体は複雑な混合物として存在することから、それらの単離は非常に困難で、さらに、高分子量の複雑な構造を有することから、構造解明された例は少ない。本研究では、新タイプの樹脂配糖体を含む、様々な樹脂配糖体の構造解明に成功したが、本研究で用いた手法は、今後の樹脂配糖体研究のモデルとなるものである。また、樹脂配糖体は、構造がユニークであることから、様々な生物活性を有する可能性がある。今後、本研究で確立した手法を用いて樹脂配糖体に関する研究が進展し、樹脂配糖体を先導化合物とする新たな医薬品創出に繋がることが期待される。
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Acylated Glycosidic Acid Methyl Esters Generated from the Convolvulin Fraction of Rhizoma Jalapae Braziliensis by Treatment with Indium(III) Chloride in Methanol2017
Author(s)
Masateru Ono, Satoko Oda, Shin Yasuda, Tomoko Mineno, Masafumi Okawa, Junei Kinjo, Hiroyuki Miyashita, Hitoshi Yoshimitsu, Toshihiro Nohara, Kazumoto Miyahara
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 65
Issue: 1
Pages: 107-111
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A New Resin Glycoside, Muricatin IX, from the Seeds of <i>Ipomoea muricata</i>2016
Author(s)
Masateru Ono, Saki Taketomi, Yuichi Kakiki, Shin Yasuda, Masafumi Okawa, Junei Kinjo, Hitoshi Yoshimitsu, Toshihiro Nohara
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 64
Issue: 9
Pages: 1408-1410
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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