Investigation for oncogenesis in IgG4-related disease
| Project/Area Number |
16K08666
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Okayama University |
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Principal Investigator |
Yausharu Sato 岡山大学, 保健学研究科, 教授 (00579831)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | IgG4-related disease / Oncogenesis / Lymphoma |
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| Outline of Final Research Achievements |
IgG4-RD is a systemic disorder involving benign mass formation due to fibrosis and intense lymphoplasmacytosis; the chronic inflammation associated with the disease might also contribute to oncogenesis. AID is overexpressed in various cancers and may be important in chronic inflammation-associated oncogenesis. We examined AID expression in IgG4-related sialadenitis and controls using immunohistochemistry and qPCR. Immunohistochemistry revealed significantly more AID-expressing cells in IgG4-related sialadenitis than in sialolithiasis or normal submandibular gland samples; qPCR yielded similar results. Thus, AID was significantly more up-regulated and had higher expression in extra-germinal centres in IgG4-RD than in non-specific inflammation or normal conditions. This report suggests that IgG4-RD has several specific causes of AID up-regulation in addition to inflammation. Furthermore, chronic inflammation-associated AID-mediated oncogenesis is possible in IgG4-RD.
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| Academic Significance and Societal Importance of the Research Achievements |
IgG4関連疾患は全身性に腫瘤や肥厚性病変を形成する炎症性疾患であるが、統計学的に悪性腫瘍を発症する頻度が高いことが統計学的に報告されている。そこでIgG4観点疾患における発がん蛋白について検索した。その結果、IgG4関連疾患においてAIDという発がん関連蛋白が高発現していることが今回の研究で明らかになった。今後は、発がん予防の目的で、このAIDを標的とした治療法への開発の糸口になり得る可能性が示唆された。
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Significance of IgG4-positive cells in severe eosinophilic chronic rhinosinusitis2019
Author(s)
Koyama T, Kariya S, Sato Y, Gion Y, Higaki T, Haruna T, Fujiwara T, Takao S, Orita Y, Kanai K, Taniguchi M, Nishizaki K, Okano M
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Journal Title
Allergol. Int.
Volume: 68
Issue: 2
Pages: 216-224
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access
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[Journal Article] The efficacy and safety of anti-interleukin-6 receptor monoclonal blockade in a renal transplant patient with Castleman disease: early post-transplant outcome.2018
Author(s)
Matsunami M, Ubara Y, Sumida K, Oshima Y, Oguro M, Kinoshita K, Tanaka K, Nakamura Y, Kinowaki K, Ohashi K, Fujii T, Igawa T, Sato Y, Ishii Y.
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Journal Title
BMC Nephrol.
Volume: 19
Pages: 263-263
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serum soluble interleukin-2 receptor as a biomarker in immunoglobulin G4-related disease.2018
Author(s)
Handa T, Matsui S, Yoshifuji H, Kodama Y, Yamamoto H, Minamoto S, Waseda Y, Sato Y, Kubo K, Mimori T, Chiba T, Hirai T, Mishima M.
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Journal Title
Mod Rheumatol.
Volume: 28
Pages: 838-844
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Gastrointestinal manifestation of immunoglobulin G4-related disease: clarification through a multicenter survey.2018
Author(s)
Notohara K, Kamisawa T, Uchida K, Zen Y, Kawano M, Kasashima S, Sato Y, Shiokawa M, Uehara T, Yoshifuji H, Hayashi H, Inoue K, Iwasaki K, Kawano H, Matsubayashi H, Moritani Y, Murakawa K, Oka Y, Tateno M, Okazaki K, Chiba T.
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Journal Title
Journal of gastroenterology
Volume: -
Pages: 845-853
DOI
Related Report
Peer Reviewed
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[Journal Article] Laryngeal squamous cell papilloma is highly associated with human papillomavirus.2018
Author(s)
Orita Y, Gion Y, Tachibana T, Ikegami K, Marunaka H, Makihara S, Yamashita Y, Miki K, Makino T, Akisada N, Akagai Y, Kimura M, Yoshino T, Nishizaki K, Sato Y.
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Journal Title
Jpn J Clin Oncol
Volume: -
Pages: 350-355
DOI
Related Report
Peer Reviewed
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[Journal Article] Tumor-associated macrophages in the development of 4-nitroquinoline-1-oxide-induced tongue squamous cell carcinoma in a mouse model.2017
Author(s)
Miki K, Orita Y, Gion Y, Takao S, Ohno K, Takeuchi M, Ito T, Minoura A, Tachibana T, Marunaka H, Makino T, Matsukawa A, Nishizaki K, Yoshino T, Sato Y.
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Journal Title
Oncology
Volume: 93
Pages: 204-212
DOI
Related Report
Peer Reviewed
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[Journal Article] Elevated serum interferon γ-induced protein 10 kDa is associated with TAFRO syndrome2017
Author(s)
Iwaki N, Gion Y, Kondo E, Kawano M, Masunari T, Moro H, Nikkuni K, Takai K, Hagihara M, Hashimoto Y, Yokota K, Okamoto M, Nakao S, Yoshino T, Sato Y
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Journal Title
Ｓｃｉｅｎｔｉｆｉｃ Ｒｅｐｏｒｔｓ
Volume: 7
Pages: 42316-42316
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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