Research on the tumorigenic mechanism of pediatric solid tumors by analyzing a epigenetics related gene
| Project/Area Number |
16K08745
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
Okita Hajime 慶應義塾大学, 医学部(信濃町), 准教授 (50317260)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
清河 信敬 国立研究開発法人国立成育医療研究センター, 小児血液・腫瘍研究部, 部長 (60195401)
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | がん / 腎腫瘍 / 遺伝子発現 / 腫瘍 / 病理学 |
|---|
| Outline of Final Research Achievements |
Clear cell sarcoma of the kidney is a pediatric renal tumor and characterized by an intragenic duplication mutation of BCOR. The intragenic duplicated sequence of this gene showed no definite transformation ability in multiple cell lines, and transformation with this gene is likely to be dependent on the cellular context. However its overexpression in 293 cells changed gene expression, including several epigenetics related genes, and it was suggested that this gene might be involved in tumorigenesis.
|
| Academic Significance and Societal Importance of the Research Achievements |
BCOR遺伝子内重複変異による腫瘍発生の機序は今までほとんど明らかにされていない。発生機序の解析の積み重ねにより、診断法・治療法開発や、BCORの機能の解明につながることが期待される。
|
Report
(4 results)
Research Products
(5 results)
-
-
-
[Presentation] Identification of BCOR internal tandem duplication in circulating tumor DNA from children with renal tumors.2018
Author(s)
Ueno-Yokohata H, Okita H, Nakasato K, Hishiki T, Tsujimoto S, Shirai R, Osumi T, Yoshimura S, Yamada Y, Shioda Y, Kiyotani C, Terashima K, Miyazaki O, , Matsumoto K, Nobutaka Kiyokawa, Takako Yoshioka and Motohiro Kato
Organizer
International Society of Paediatric Oncology
Related Report
Int'l Joint Research
-
-
