• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research on the tumorigenic mechanism of pediatric solid tumors by analyzing a epigenetics related gene

Research Project

Project/Area Number 16K08745
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental pathology
Research InstitutionKeio University

Principal Investigator

Okita Hajime  慶應義塾大学, 医学部(信濃町), 准教授 (50317260)

Co-Investigator(Kenkyū-buntansha) 清河 信敬  国立研究開発法人国立成育医療研究センター, 小児血液・腫瘍研究部, 部長 (60195401)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsがん / 腎腫瘍 / 遺伝子発現 / 腫瘍 / 病理学
Outline of Final Research Achievements

Clear cell sarcoma of the kidney is a pediatric renal tumor and characterized by an intragenic duplication mutation of BCOR. The intragenic duplicated sequence of this gene showed no definite transformation ability in multiple cell lines, and transformation with this gene is likely to be dependent on the cellular context. However its overexpression in 293 cells changed gene expression, including several epigenetics related genes, and it was suggested that this gene might be involved in tumorigenesis.

Academic Significance and Societal Importance of the Research Achievements

BCOR遺伝子内重複変異による腫瘍発生の機序は今までほとんど明らかにされていない。発生機序の解析の積み重ねにより、診断法・治療法開発や、BCORの機能の解明につながることが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Combined Genetic and Chromosomal Characterization of Wilms Tumors Identifies Chromosome 12 Gain as a Potential New Marker Predicting a Favorable Outcome2019

    • Author(s)
      Haruta Masayuki、Arai Yasuhito、Okita Hajime、Tanaka Yukichi、Takimoto Tetsuya、Sugino Ryuichi P.、Yamada Yasuhiro、Kamijo Takehiko、Oue Takaharu、Fukuzawa Masahiro、Koshinaga Tsugumichi、Kaneko Yasuhiko
    • Journal Title

      Neoplasia

      Volume: 21 Issue: 1 Pages: 117-131

    • DOI

      10.1016/j.neo.2018.10.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 小児横紋筋肉腫の分子病理2018

    • Author(s)
      大喜多肇
    • Organizer
      第60回日本小児血液・がん学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Identification of BCOR internal tandem duplication in circulating tumor DNA from children with renal tumors.2018

    • Author(s)
      Ueno-Yokohata H, Okita H, Nakasato K, Hishiki T, Tsujimoto S, Shirai R, Osumi T, Yoshimura S, Yamada Y, Shioda Y, Kiyotani C, Terashima K, Miyazaki O, , Matsumoto K, Nobutaka Kiyokawa, Takako Yoshioka and Motohiro Kato
    • Organizer
      International Society of Paediatric Oncology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腎芽腫において予後と相関する遺伝子・染色体異常2018

    • Author(s)
      1.春田 雅之, 新井 康仁, 大喜多 肇, 上條 岳彦, 野崎 美和子, 大植 孝治, 福澤 正洋, 越永 従道.
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小児腎腫瘍におけるポリコーム複合体構成因子の発現解析2017

    • Author(s)
      Ueno H. Okita H, Kiyokawa N.
    • Organizer
      第58回日本小児血液・がん学会学術集会
    • Related Report
      2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi