Novel anti-cancer therapy with cyclic sulfide compounds regulating macrophage activation

• Project/Area Number: 16K09247
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kumamoto University
• Principal Investigator: Fujiwara Yukio 熊本大学, 大学院生命科学研究部(医), 講師 (70452886)
• Co-Investigator(Kenkyū-buntansha): 哈 斯塔 (Horlad Hasita) 熊本大学, 大学院生命科学研究部(医), 研究員 (00644840) ; 白石 大偉輔 熊本大学, 医学部附属病院, 非常勤診療医師 (70769512)
• Research Collaborator: Komohara Yoshihiro ; Ohnishi Koji
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: マクロファージクロファージ / ガン / 代替医療 / マクロファージ / 環状スルフィド化合物 / ガン免疫 / スルフィド化合物

Outline of Final Research Achievements

It is well known that regulating macrophages activation (regulation from M2-like phenotype into M1-like phenotype) in tumor microenvironment is novel strategy for tumor therapy. In the present study, we identified cyclic sulfide compounds regulating macrophage activation and those compounds suppressed tumor proliferation under co-culture with macrophages and tumor cells. Furthermore, administration of those compounds significantly suppressed tumor development in tumor-bearing mice, thus indicating that cyclic sulfide compounds may be potentially new strategy for tumor prevention and therapy.

Academic Significance and Societal Importance of the Research Achievements

近年、遺伝子改変動物等を用いた国内外での研究により、Mφ活性化調節が病態の改善に有効であると知られている。また、腫瘍内にはM2Mφなどの免疫抑制的に働く細胞が多数浸潤しており、腫瘍免疫を抑制することで腫瘍増殖に関与している。ゆえに、既存の癌治療が著効しない症例ではM2Mφによる免疫抑制が原因であると考えられている。本研究で同定した環状スルフィド化合物はMφの活性化制御という既存の治療薬とは異なるメカニズムで腫瘍進展を抑制し、ガン治療に応用できる可能が示唆された。つまり本研究成果は、将来的に新たな分子標的薬を開発するための基礎的知見として学術的・社会的にも意義ある研究成果であると考えられる。

Research Products

• [Int'l Joint Research] Tanta University(Egypt)
• [Int'l Joint Research] Tanta University(Egypt)
• [Journal Article] Phlenumdines D and E, new Lycopodium alkaloids from Phlegmariurus nummulariifolius, and their regulatory effects on macrophage differentiation during tumor development (2019)
  • Author(s): Nakayama W, Fujiwara Y, Kosuge Y, Monthakantirat O, Fujikawa K, Watthana S, Kitanaka S, Makino T, Ishiuchia K.
  • Journal Title: Phytochmiestry Letters Volume: 29 Pages: 98-103
  • DOI: 10.1016/j.phytol.2018.11.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Preparation of fibrin hydrogels to promote the recruitment of anti-inflammatory macrophages (2019)
  • Author(s): Tanaka Ryusuke、Saito Yoichi、Fujiwara Yukio、Jo Jun-ichiro、Tabata Yasuhiko
  • Journal Title: Acta Biomater Volume: in press Pages: 152-162
  • DOI: 10.1016/j.actbio.2019.03.011
  • Peer Reviewed
• [Journal Article] Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis. (2018)
  • Author(s): Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishii N, Fukuda K, Murakami S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Koga T, Yamagata K, Takeya M, Araki E
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 印刷中 Pages: 994-1006
  • DOI: 10.1161/atvbaha.117.310320
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CD163 is required for protumoral activation of macrophages in human and murine sarcoma. (2018)
  • Author(s): Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, Cheng P, Nakagata N, Mizuta H, Bekki H, Nakashima Y, Oda Y, Takeya M, Komohara Y.
  • Journal Title: Cancer Research Volume: in press Pages: 3255-3266
  • DOI: 10.1158/0008-5472.can-17-2011
  • Peer Reviewed
• [Journal Article] Genetic Fusion of Type-I Interferon to a Recombinant Albumin Mutant with polymannosylated N-linked oligosaccharide attached is a Novel and Superior Kupffer Cell Targeting Agent for the Treatment of Hepatitis. (2018)
  • Author(s): Minayoshi Y, Maeda H, Yanagisawa H, Hamasaki K, Mizuta Y, Nishida K, Kinoshita R, Enoki Y, Imafuku T, Chuang VTG, Koga T, Fujiwara Y, Takeya M, Sonoda K, Wakayama T, Taguchi K, Ishima Y, Ishida T, Iwakiri Y, Tanaka M, Sasaki Y, Watanabe H, Otagiri M, Maruyama T.
  • Journal Title: Drug Deliv. Volume: 25 Pages: 1055-1065
  • DOI: 10.1080/10717544.2018.1464083
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Natural compounds that regulate lymph node sinus macrophages: Inducing an anti-tumor effect by regulating macrophage activation (2018)
  • Author(s): Fujiwara Y, Saito Y, Shiota T, Cheng P, Ikeda T, Ohnishi K, Takeya M, Komohara Y
  • Journal Title: J Clin Exp Hematopathol Volume: 58 Issue: 1 Pages: 17-23
  • DOI: 10.3960/jslrt.17032
  • NAID: 130006512988
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed / Open Access
• [Journal Article] New cyclic sulfides extracted from Allium sativum: garlicnins P, J2, and Q (2018)
  • Author(s): Nohara Toshihiro、Ono Masateru、Nishioka Naho、Masuda Fuka、Fujiwara Yukio、Ikeda Tsuyoshi、Nakano Daisuke、Kinjo Junei
  • Journal Title: Journal of Natural Medicines Volume: 72 Pages: 335-341
  • DOI: 10.1007/s11418-017-1151-0
  • Peer Reviewed
• [Journal Article] New cyclic sulfides, garlicnins I2, M, N, and O, from Allium sativum (2018)
  • Author(s): Nohara Toshihiro、Ono Masateru、Nishioka Naho、Masuda Fuka、Fujiwara Yukio、Ikeda Tsuyoshi、Nakano Daisuke、Kinjo Junei
  • Journal Title: Journal of Natural Medicines Volume: 72 Pages: 326-331
  • DOI: 10.1007/s11418-017-1133-2
  • Peer Reviewed
• [Journal Article] Production of Single-Chain Fv Antibodies Specific for GA-Pyridine, an Advanced Glycation End-Product (AGE), with Reduced Inter-Domain Motion (2017)
  • Author(s): Fukuda N、Noi K、Weng L、Kobashigawa Y、Miyazaki H、Wakeyama Y、Takaki M、Nakahara Y、Tatsuno Y、Uchida-Kamekura M、Suwa Y、Sato T、Ichikawa-Tomikawa N、Nomizu M、Fujiwara Y、Ohsaka F、Saitoh T、Maenaka K、Kumeta H、Shinya S、Kojima C、Ogura T、Morioka H
  • Journal Title: Molecules Volume: 22 Pages: 1695-1695
  • DOI: 10.3390/molecules22101695
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Selective depletion of cultured macrophages by magnetite nanoparticles modified with gelatin (2017)
  • Author(s): Komohara Yoshihiro、Kawauchi Ryuta、Makiyama Erika、Mikami Kazuki、Horlad Hasita、Fujiwara Yukio、Kida Tetsuya、Takeya Motohiro、Niidome Takuro
  • Journal Title: Experimental and Therapeutic Medicine Volume: 14 Pages: 1640-1646
  • DOI: 10.3892/etm.2017.4640
  • Peer Reviewed / Open Access
• [Journal Article] Optimum immunohistochemical procedures for analysis of macrophages in human and mouse formalin fixed paraffin-embedded tissue samples (2017)
  • Author(s): Nakagawa T, Ohnishi K, Kosaki Y, Saito Y, Horlad H, Fujiwara Y, Takeya M, Komohara Y
  • Journal Title: J Clin Exp Hematopathol Volume: 57 Issue: 1 Pages: 31-36
  • DOI: 10.3960/jslrt.17017
  • NAID: 130005709518
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed / Open Access
• [Journal Article] Stat3 inhibitor abrogates the expression of PD-1 ligands on lymphoma cell lines (2017)
  • Author(s): Ma C, Horlad H, Pan C, Yano H, Ohnishi K, Fujiwara Y, Matsuoka M, Lee A, Niidome T, Yamanaka R, Takeya M, Komohara Y
  • Journal Title: J Clin Exp Hematopathol Volume: in press Issue: 1 Pages: 21-25
  • DOI: 10.3960/jslrt.17006
  • NAID: 130005709510
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages. (2017)
  • Author(s): Komohara Y, Ma C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shimosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M
  • Journal Title: J Clin Exp Hematopathol Volume: 57 Issue: 1 Pages: 15-20
  • DOI: 10.3960/jslrt.17003
  • NAID: 130005709559
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed / Open Access
• [Journal Article] The cell-cell interaction between tumor-associated macrophages and small cell lung cancer cells is involved in tumor progression via STAT3 activation (2017)
  • Author(s): Iriki Toyohisa、Ohnishi Koji、Fujiwara Yukio、Horlad Hasita、Saito Yoichi、Pan Cheng、Ikeda Koei、Mori Takeshi、Suzuki Makoto、Ichiyasu Hidenori、Kohrogi Hirotsugu、Takeya Motohiro、Komohara Yoshihiro
  • Journal Title: Lung Cancer Volume: 106 Pages: 22-32
  • DOI: 10.1016/j.lungcan.2017.01.003
  • Peer Reviewed
• [Journal Article] Antitumor <i>Allium</i> Sulfides (2017)
  • Author(s): Nohara T, Fujiwara Y, El-Aasr M, Ikeda T, Ono M, Nakano D, Kinjo J.
  • Journal Title: CHEMICAL & PHARMACEUTICAL BULLETIN Volume: 65 Issue: 3 Pages: 209-217
  • DOI: 10.1248/cpb.c16-00844
  • NAID: 130005397349
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Atypical Cyclic Sulfides, Garlicnins G, I, and J, Extracted from <i>Allium sativum</i> (2017)
  • Author(s): Ono M, Fujiwara Y, Ikeda T, Pan C, El-Aasr M, Lee JH, Nakano D, Kinjo J, Nohara T.
  • Journal Title: CHEMICAL & PHARMACEUTICAL BULLETIN Volume: 65 Issue: 1 Pages: 102-106
  • DOI: 10.1248/cpb.c16-00648
  • NAID: 130005187738
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Guanylate-binding protein 5 is a marker of interferon-γ- induced classically activated macrophages. (2016)
  • Author(s): Fujiwara Y, Hizukuri Y, Yamashiro K, Makita N, Ohnishi K, Takeya M, Komohara Y, Hayashi Y.
  • Journal Title: Clinical & Translational Immunology Volume: 5
  • DOI: 10.1038/cti.2016.59
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] An IL-27/Stat3 axis induces expression of programmed cell death 1 ligands (PD-L1/2) on infiltrating macrophages in lymphoma. (2016)
  • Author(s): Horlad H, Ma C, Yano H, Pan C, Ohnishi K, Fujiwara Y, Endo S, Kikukawa Y, Okuno Y, Matsuoka M, Takeya M, Komohara Y.
  • Journal Title: Cancer Sci Volume: 107 Pages: 1696-1704
  • DOI: 10.1111/cas.13065
  • NAID: 120006223644
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] TIM-3 expression in lymphoma cells predicts chemoresistance in patients with adult T-cell leukemia/lymphoma (ATLL). (2016)
  • Author(s): Horlad H, Ohnishi K, Ma C, Fujiwara Y, Niino D, Ohshima K, Jinushi M, Matsuoka M, Takeya M, Komohara Y.
  • Journal Title: Oncol Lett. Volume: 12 Pages: 1519-1524
  • DOI: 10.3892/ol.2016.4774
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages. (2016)
  • Author(s): Tsuboki J, Fujiwara Y, Horlad H, Shiraishi D, Nohara T, Tayama S, Motohara T, Saito Y, Ikeda T, Takaishi K, Tashiro H, Yonemoto Y, Katabuchi H, Takeya M, Komohara Y.
  • Journal Title: Sci Rep. Volume: 6 Pages: 29588-29588
  • DOI: 10.1038/srep29588
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells (2016)
  • Author(s): Fujiwara Yukio, Horlad Hasita, Shiraishi Daisuke, Tsuboki Junko, Kudo Rino, Ikeda Tsuyoshi, Nohara Toshihiro, Takeya Motohiro, Komohara Yoshihiro
  • Journal Title: Mol Nutr Food Res Volume: 60(11) Pages: 2467-2480
  • DOI: 10.1002/mnfr.201500995
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Serralongamines B-D, Three New Lycopodium Alkaloids from Lycopodium serratum var. longipetiolatum, and their inhibitory effects on foam cell formation in macrophages (2016)
  • Author(s): Kan’ihiro Ishiuchi, Wen-Ping Jiang, Yukio Fujiwara, Jin-Bin Wu, Susumu Kitanaka
  • Journal Title: Bioorg Med Chem Lett. Volume: 26 Pages: 2636-2640
  • DOI: 10.1016/j.bmcl.2016.04.019
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Infiltration of tumor-associated macrophages is involved in CD44 expression in clear cell renal cell carcinoma. (2016)
  • Author(s): Ma C, Komohara Y, Ohnishi K, Shimoji T, Kuwahara N, Sakumura Y, Matsuishi K, Fujiwara Y, Motoshima T, Takahashi W, Yamada S, Kitada S, Fujimoto N, Nakayama T, Eto M, Takeya M.
  • Journal Title: Cancer Sci Volume: Epub Pages: 700-706
  • DOI: 10.1111/cas.12917
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Two new prenylflavonoids from Epimedii Herba and their inhibitory effects on advanced glycation end-products (2016)
  • Author(s): Nakashima, Keisuke; Miyashita, Hiroyuki; Yoshimitsu, Hitoshi; Fujiwara, Yukio; Nagai, Ryoji; Ikeda, Tsuyoshi
  • Journal Title: J Nat Med. Volume: 70 (2) Pages: 290-295
  • DOI: 10.1007/s11418-015-0962-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Two new bicyclic sulfoxides from Welsh onion (2016)
  • Author(s): Nohara, Toshihiro; Fujiwara, Yukio; Ikeda, Tsuyoshi; Murakami, Kotaro; Ono, Masateru; El-Aasr, Mona; Nakano, Daisuke; Kinjo, Junei
  • Journal Title: J Nat Med. Volume: 70 (2) Pages: 260-265
  • DOI: 10.1007/s11418-015-0947-z
  • NAID: 40020758269
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy. (2016)
  • Author(s): Yoshihiro Komohara, Yukio Fujiwara, Koji Ohnishi, Motohiro Takeya
  • Journal Title: Adv Drug Deliv Rev. Volume: 24 Pages: 180-185
  • DOI: 10.1016/j.addr.2015.11.009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Orosomucoid is indirectly involved in tumor development via macrophages (2019)
  • Author(s): Yukio Fujiwara, Cheng Pan, Koji Ohnishi, Yoshihiro Komohara
  • Organizer: 11th AACR-JCA Joint Conference
  • Int'l Joint Research
• [Presentation] 天然由来環状硫黄化合物による腫瘍関連マクロファージをターゲットとしたがん治療への応用 (2019)
  • Author(s): 藤原 章雄
  • Organizer: 日本薬学会第139年会
  • Invited
• [Presentation] 抗腫瘍作用を期待したリンパ節洞マクロファージの活性化を調節する化合物の探索 (2018)
  • Author(s): 藤原章雄、西東洋一、塩田拓也、潘程、大西紘二、竹屋元裕、菰原義弘
  • Organizer: 第107回日本病理学会総会
• [Presentation] マクロファージCD163の肉腫進展における機能解析 (2018)
  • Author(s): 藤原 章雄、白石 大偉輔、西東 洋一、潘 程、小田 義直、竹屋 元裕、菰原 義弘
  • Organizer: 第58回 日本リンパ網内系学会総会
• [Presentation] 塩分を吸着する食品素材の探索 (2018)
  • Author(s): 藤原章雄、前田涼子1、竹下英徳、菰原義弘
  • Organizer: 日本食品化学会 第24回総会・学術大会
• [Presentation] Macropahge-regulating compounds inhibit small cell lung cancer proliferation by suppressing the protumour function of macrophages (2018)
  • Author(s): Yukio Fujiwara, Toyohisa Iriki, Hasita Horlad, Yoichi Saito, Cheng Pan, Takenobu Nakagawa, Ikuko Miyagawa, Koji Ohnishi, Yoshihiro Komohara
  • Organizer: The 6th JCA-AACR Special Joint Conference
  • Int'l Joint Research
• [Presentation] 肉腫の腫瘍微小環境におけるマクロファージスカベンジャー受容体 CD163の機能解析 (2018)
  • Author(s): 藤原 章雄、白石 大偉輔、Hasita Horlad、菰原 義弘
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] 天然化合物による糖化物質の生成と作用の制御 (2018)
  • Author(s): 藤原章雄
  • Organizer: 第41回日本分子生物学会年会
  • Invited
• [Presentation] 腫瘍微小環境におけるAGPのマクロファージに対する作用 (2018)
  • Author(s): 藤原章雄、西東洋一、大西紘二、菰原義弘
  • Organizer: 第16回がんとハイポキシア研究会
• [Presentation] Study on glycated-hemoglobin metabolism of macrophages in tumor microenvironment (2018)
  • Author(s): Yukio Fujiwara, Cheng Pan, Takenobu Nakagawa, Yoshihiro Komohara
  • Organizer: 13th International Symposium on the Maillard reaction
  • Int'l Joint Research
• [Presentation] CD163陽性マクロファージを誘導する物資の生体材料への応用の可能性 (2018)
  • Author(s): 藤原章雄、西東洋一、菰原義弘
  • Organizer: 第45回日本臨床バイオメカニクス学会
• [Presentation] 腫瘍進展におけるマクロファージスカベンジャー受容体CD163の機能解析 (2018)
  • Author(s): 藤原章雄、白石大偉輔、潘 程、中川雄伸、宮川育子、竹屋元裕、菰原義弘
  • Organizer: 日本薬学会 第138回年会
• [Presentation] ヒトマクロファージをターゲットとした創薬研究 (2018)
  • Author(s): 藤原章雄、西東洋一、Horlad Hasita、菰原義弘
  • Organizer: 第7回 超異分野学会
• [Presentation] 高悪性度リンパ腫ではコレステロール代謝経路が新たな治療ターゲットとなりうる (2017)
  • Author(s): 藤原章雄、Hasita HORLAD、潘 程、中川雄伸、林田唯、竹屋元裕、菰原義弘
  • Organizer: 日本薬学会 第137回年会
  • Place of Presentation: 仙台、仙台国際センター
  • Year and Date: 2017-03-24
• [Presentation] タマネギ由来成分Onionin Aはマクロファージの活性化を制御することで腫瘍の進展を抑制する (2017)
  • Author(s): 藤原章雄、坪木純子、Horlad Hasita、野原稔弘、池田剛、竹屋元裕、菰原義弘
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都、京都女子大学
  • Year and Date: 2017-03-17
• [Presentation] 悪性リンパ腫に対する脂質代謝阻害剤の有用性 (2017)
  • Author(s): 藤原章雄、Horlad Hasita、Pan Cheng、矢野浩夢、西東洋一、宮川育子、中川雄伸、竹屋元裕、菰原義弘
  • Organizer: 2017年度 生命科学系学会合同年次大会（ConBio2017）
• [Presentation] 摩耗粉の形態がヒトマクロファージの活性化に与える影響 (2017)
  • Author(s): 藤原章雄
  • Organizer: 第44回 日本臨床バイオメカニクス学会
  • Invited
• [Presentation] AGEs 研究が現在の研究内容に及ぼした影響 (2017)
  • Author(s): 藤原章雄
  • Organizer: 第27回 日本メイラード学会学術集会
  • Invited
• [Presentation] The effect of AGP on tumor proliferation via macrophage activation (2017)
  • Author(s): Yukio Fujiwara, Chang Pan, Yoshihiro Komohara, Motohiro Takeya
  • Organizer: Cytokine2017
  • Int'l Joint Research
• [Presentation] Orosomucoidのマクロファージを介した間接的な腫瘍進展への関与 (2017)
  • Author(s): 藤原章雄、潘程、入來豊久、西東洋一、竹屋元裕、菰原義弘
  • Organizer: 第76回 日本癌学会学術総会
• [Presentation] コレステロール代謝を標的としたガンの新たな治療戦略 (2017)
  • Author(s): 藤原章雄、Hasita Horlad、Pan Cheng、矢野浩夢、宮川育子、中川雄伸、竹屋元裕、菰原義弘
  • Organizer: 第５回 がんと代謝研究会
• [Presentation] 炎症性マクロファージの新たなマーカー探索 (2017)
  • Author(s): 藤原章雄、菰原義弘、大西紘二、宮川育子、中川雄伸、竹屋元裕
  • Organizer: 第70回 日本酸化ストレス学会学術集会
• [Presentation] タマネギ成分のマクロファージ活性化制御を介した抗腫瘍作用と新たな抗ガン剤のリード化合物としての可能性 (2017)
  • Author(s): 藤原章雄、坪木純子、野原稔弘、中川雄伸、菰原義弘、竹屋元裕
  • Organizer: 日本食品化学学会 第23回総会・学術大会
• [Presentation] Onionin A, a sulfur-containing compound isolated from onions, impairs tumor progression by inhibiting the protumoral functions of macrophages (2017)
  • Author(s): Yukio Fujiwara, Junko Tsuboki, Hasita Horlad, Daisuke Shiraishi, Toshihiro Nohara, Yoshihiro Komohara, Motohiro Takeya
  • Organizer: Keystone Symposia, Mononuclear Phagocytes in Health, Immune Defense and Disease (D3)
  • Int'l Joint Research
• [Presentation] GPはマクロファージを介して間接的に腫瘍の活性化に関与する (2017)
  • Author(s): 藤原章雄、潘程、入來豊久、西東洋一、竹屋元裕、菰原義弘
  • Organizer: 第106回 日本病理学会総会
• [Presentation] Inhibitory effect on Lymphoma Cell Proliferation by Regulating Cholesterol Metabolism Pathway. (2016)
  • Author(s): Yukio Fujiwara, Hasita Horlad, Daisuke Niino, Yutaka Okuno, Kikukawa Yoshitaka, Masao Matsuoka, Motohiro Takeya, Yoshihiro Komohara
  • Organizer: THE 1ST MEETING OF THE YONGLIN HEALTHCARE SYMPOSIUM SERIES-“DNA PROCESSES, DRUGS AND CANCER
  • Place of Presentation: National Taiwan University, Taiwan
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] 脂質代謝制御によるリンパ腫に対する新たな治療戦略 (2016)
  • Author(s): 藤原章雄、Horlad Hasita、新野大介、奥野豊、菊川佳敬、松岡雅雄、竹屋元裕、菰原義弘
  • Organizer: 第75回 日本癌学会学術総会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2016-10-06
• [Presentation] ヘモグロビンスカベンジャー(CD163)と脂質代謝との関連性について (2016)
  • Author(s): 藤原章雄、西東洋一、菰原義弘、竹屋元裕.
  • Organizer: 第89回 日本生化学会大会
  • Place of Presentation: 仙台、仙台国際センター
  • Year and Date: 2016-09-25
• [Presentation] コレステロール代謝経路を標的とした高悪性度リンパ腫に対する新たな治療戦略 (2016)
  • Author(s): 藤原章雄、Horlad Hasita、菰原義弘、新野大介、奥野豊、菊川佳敬、松岡雅雄、竹屋元裕
  • Organizer: 第56回 日本リンパ網内系学会総会
  • Place of Presentation: 熊本、ホテル日航熊本
  • Year and Date: 2016-09-01
• [Presentation] Inhibitory Effect on Lymphoma Cells Proliferation by Regulating Cholesterol Metabolism Pathway (2016)
  • Author(s): Yukio Fujiwara, Hasita Horlad, Daisuke Niino, Yutaka Okuno, Yoshitaka Kikukawa, Masao Matsuoka, Motohiro Takeya, Yoshihiro Komohara
  • Organizer: The 5th JCA-AACR Special Joint Conference
  • Place of Presentation: (Tokyo Bay Maihama Hotel Club Resort, Urayasu, Chiba
  • Year and Date: 2016-07-13
  • Int'l Joint Research
• [Presentation] CD163, a scavenger receptor for the hemoglobin-haptoglobin complex, relates to tumorgenesis in murine sarcoma model. (2016)
  • Author(s): Yukio Fujiwara, Daisuke Shiraishi, Hasita Horlad, Hiroshi Mizuta, Yoshihiro Komohara, Motohiro Takeya
  • Organizer: The 24th International Symposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: Tokyo Bay Maihama Hotel Club Resort, Urayasu, Chiba
  • Year and Date: 2016-06-04
  • Int'l Joint Research
• [Remarks] 熊本大学大学院生命科学研究部細胞病理学分野ホームページ
  • URL: http://www.medic.kumamoto-u.ac.jp/dept/patho2/patho2.html
• [Remarks] 熊本大学大学院生命科学研究部細胞病理学分野ホームページ
  • URL: http://srv02.medic.kumamoto-u.ac.jp/dept/patho2/patho2.html