Evaluation of usefulness of software for the analysis of ADC value in MRI based brachytherapy

• Project/Area Number: 16K10394
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: Yoshida Kenji 神戸大学, 医学部附属病院, 特命准教授 (80351906)
• Co-Investigator(Kenkyū-buntansha): 宮脇 大輔 神戸大学, 医学部附属病院, 特命講師 (30546502) ; 高橋 哲 神戸大学, 医学研究科, 非常勤講師 (40311758) ; 西川 遼 神戸大学, 医学部附属病院, 医員 (80736835)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 小線源治療 / 画像誘導小線源治療 / 放射線治療学

Outline of Final Research Achievements

No useful results could be obtained from the change of ADC value using histogram analyses.Therefore, correlation between ADC value of GTV at diagnosis and HR-CTV at first brachytherapy (BT) was investigated. Moderate correlation was observed between 2 factors. In Addition, ADC value of recurrent cases showed atypical patterns. This might indicate the usefulness of this Analysis. However, only 20 cases could be evaluated at that time and Long term accumulation of the cases and more detailed Analysis were requried. Now 90 cases are evaluable and new invastigation should be performed as much as possible.

Academic Significance and Societal Importance of the Research Achievements

今後MRIを用いた子宮頸癌に対する画像誘導小線源治療 (IGBT)は日本においても広まってゆくと考えられる。MRIはCTより得られる情報が豊富であり、その一つがADC値である。当院はMRIを用いたIGBTにおける先駆施設であり、今のところ症例数は十分とは言えないがそれでも日本において有数である。その当院に於いてADC値等から何らかの確定的知見が得られるとすればそれは非常に意義の高いものであるといえる。

Research Products

• [Journal Article] Comparison of dosimetric parameters in the treatment planning of magnetic resonance imaging-based intracavitary image-guided adaptive brachytherapy with and without optimization using the central shielding technique. (2018)
  • Author(s): Nishikawa R, Yoshida K, Ebina Y, Omoteda M, Miyawaki D, Ishihara T, Ejima Y, Akasaka H, Satoh H, Kyotani K, Takahashi S, Sasaki R.
  • Journal Title: Journal of Radiation Research Volume: 印刷中 Issue: 3 Pages: 316-326
  • DOI: 10.1093/jrr/rry009
  • NAID: 120006477549
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Experience of Image Guided Brachytherapy using Magnetic Resonance Imaging for Gynecologic malignanciesat Kobe University Hospital (2019)
  • Author(s): Kenji Yoshida
  • Organizer: 3-D IMAGE-GUIDED ADAPTIVE BRACHYTHERAPY FOR GYNECOLOGIC MALIGNANCIES
  • Invited
• [Presentation] Impact of 18F-FDG PET / MRI imaging biomarkers (SUV, ADC) on the tumor response of cervical cancer to external beam radiotherapy at the time of brachytherapy (2018)
  • Author(s): Kenji Yoshida, Munenobu Nogami, Yasuhiko Ebina, Kazuhiro Kubo, Katsusuke Kyotani, Mayumi Omoteda, Ryo Nishikawa, Satoshi Seno, Ryhohei Sasaki
  • Organizer: ASTRO2017 (the 60th ASTRO annual meeting)
  • Int'l Joint Research
• [Presentation] 治療計画支援装置を用いた子宮頸癌放射線治療における小線源・外部照射線量合算による中央遮蔽の線量的影響の初期検討 (2018)
  • Author(s): 吉田賢史 赤坂浩亮 表田真弓 西川遼 佐々木香織 妹尾悟史 蝦名康彦 佐々木良平
  • Organizer: 第31回日本放射線腫瘍学会
• [Presentation] MRI-based IGBTにおける画像取得の間に生じるリスク臓器線量変化の検討 (2018)
  • Author(s): Mayumi Omoteda, Kenji Yoshida, Ryo Nishikawa, Hiroaki Akasaka2, Katsusuke Kyotani1, Takaharu Nishitani, Yasuhiko Ebina, Ryohei Sasaki , Akiko Kusaka
  • Organizer: 第31回日本放射線腫瘍学会
• [Presentation] 画像誘導小線源治療時の遺残腫瘍体積と腫瘍縮小率に基づく子宮頸癌患者のリスク分類 (2018)
  • Author(s): 西川遼、吉田賢史、蝦名康彦、表田真弓、江島泰生、宮脇大輔、石原武明、高橋哲、佐々木良平
  • Organizer: 第77回日本医学放射線学会総会
• [Presentation] 3.Comparison of dosimetric parameters in the treatment plannings of magnetic resonance imaging based intracavitary image guided adaptive brachytherapy with and without optimization in combination with external beam radiotherapy using Japanese specific central shielding technique. (2017)
  • Author(s): Kenji Yoshida, Daisuke Miyawaki, Ryo Nishikawa, Hiroaki Akasaka, Yoshiro Matsuo, Mayumi Omoteda, Katsusuke Kyotani, Hitoaki Satoh, Saki Osuga, Yasuyuki Shimizu, Yasuhiko Ebina, Satoru Takahashi, Ryohei Sasaki.
  • Organizer: The 5th Japan-Taiwan Radiation Oncology Symposium
  • Int'l Joint Research
• [Presentation] Risk Group Analyses in Cervical Cancer Patients Based on Residual Tumor Volume and Tumor Reduction Ratio at the Time of Image Guided Adaptive Brachytherapy. (2017)
  • Author(s): Ryo Nishikawa, Kenji Yoshida, Yasuhiko Ebina, Mayumi Omoteda, Yasuo Ejima, Daisuke Miyawaki, Takeaki Ishihara, Satoru Takahashi, and Ryohei Sasaki.
  • Organizer: ASTRO2017 (the 59th ASTRO annual meeting)
  • Int'l Joint Research
• [Presentation] 子宮頸癌に対する組織内照射併用腔内照射と腔内照射治療計画の比較 (2017)
  • Author(s): 表田真弓、吉田賢史、西川遼、京谷勉輔、宮脇大輔、蝦名康彦、山田秀人、高橋哲、青山裕一、佐々木良平
  • Organizer: 第30回日本放射線腫瘍学会
• [Presentation] 子宮頸癌における外部照射期間中のADC値の変化に関する検討 (2016)
  • Author(s): 西川遼
  • Organizer: 第29回日本放射線腫瘍学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2016-11-25
• [Presentation] 子宮頸癌化学放射線療法中のADC値の変化に関する検討治療前と腔内照直前の比較 (2016)
  • Author(s): 佐々木香織
  • Organizer: 第385回日本医学放射線学会関西地方会
  • Place of Presentation: ホテルエルセラーン大阪
• [Book] "Radiotherapy" Image guided adaptive brachytherapy for cervical cancer using magnetic resonance imaging: Overview and experience. (2017)
  • Author(s): Kenji Yoshida, Ryo Nishikawa, Daisuke Miyawaki, Yasuhiko Ebina, Ryohei Sasaki
  • Total Pages: 280
  • Publisher: INTECH
  • ISBN: 9789535151265