Application to bone fracture treatment using the bioadhesive derived from a plant

• Project/Area Number: 16K10878
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kurume University
• Principal Investigator: Shirahama Masahiro 久留米大学, 医学部, 教授 (90196626)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 骨折治療 / 整形外科学

Outline of Final Research Achievements

Using adhesive (as follows biobond) derived from a plant, I proved the biocompatibility for the bone and performed a study to inspect possibility as adhesive for the world's first osteosynthesis. The biobond was superior to biocompatibility as adhesive, and the inflammatory reaction was control and a result not to change at all, but when it was hydrophilic and was poor, and blood and an exudate invaded it between a bone and bond, adhesive strength was remarkable and decreased, and the fixation as I could endure bone fracture treatment was not provided. The improvement to add a hydrophilic group to biobond in itself increased it, but adhesive property in itself decreased, and it was thought that the practical use was difficult.

Academic Significance and Societal Importance of the Research Achievements

現在行われている骨折治療はチタンなどの金属プレートやワイヤーで骨を直接固定する内固定が 一般的で、粉砕骨折や固定螺子を挿入できないような小さな骨片に対しては放置しているのが現状である。本研究では植物由来接着剤(以下バイオボンド)を用いて、骨に対する生体親和性を立証し、世界初の骨接合用の接着剤としての可能性を検証する事である。これにより、より解剖的に正確な整復と、強固な初期固定を獲得できることが期待できる。さらに現状で整復・固定できなかった骨折も固定ができるようになる可能性があり、骨折治療を劇的に変える可能性があると考える。