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Introduction of minimally invasive diagnosis and treatment system using 2-dimensional blood flowmeter in oral and maxillofacial field

Research Project

Project/Area Number 16K11673
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionWakayama Medical University

Principal Investigator

Miyazaki Hidetaka  和歌山県立医科大学, 医学部, 講師 (70420271)

Co-Investigator(Kenkyū-buntansha) 工藤 敏文  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (50431911)
井上 芳徳  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (70280964)
柿崎 裕彦  愛知医科大学, 医学部, 教授 (20329783)
高橋 靖弘  愛知医科大学, 医学部, 准教授 (70557206)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords2次元レーザー血流計 / 蛍光血管造影 / インドシアニングリーン / ICG / 血流 / 口腔
Outline of Final Research Achievements

Focusing on a 2-dimensional laser measuring system of blood perfusion and fluorescent angiography using indocyanine green (ICG), the study was performed aiming to apply them to various kinds of the surgical operations or diagnosis. We suggested the parameters for quantitative assessment of blood perfusion using ICG angiography in the studies of clinical cases. We also established laser speckle contrast imaging system with thermal loading using 2-dimensional laser blood flowmeter. Both of them can be useful methods for objective evaluation for the tissue perfusion.

Academic Significance and Societal Importance of the Research Achievements

組織を循環する血流の評価は、移植手術に限らずありとあらゆる外科手術の成功や、創傷治癒の観点から重要である。それに対する客観的な評価法の確立は患者への安全確実な治療を提供する上で必要不可欠と考えられる。近年開発された2次元レーザー組織血流測定システムと蛍光血管造影に着目し、研究を行った。これにより、それぞれの有用性が分かっただけでなく、有茎皮弁の血行動態も明らかにすることができた。
安全・確実で非侵襲的な診断・治療は患者の負担を減らし、QOLを向上させ、医療費の負担を減らすことになる。今後この研究を基に細胞・組織レベルでの微細な反応の解析まで研究の幅が拡がる可能性がある。
が

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2020 2019 2018 2017 2016

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 5 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] The Comparison of Long-Term Results between Aortofemoral and Axillofemoral Bypass for Patients with Aortoiliac Occlusive Disease2020

    • Author(s)
      Kimihiro Igari, Toshifumi Kudo, Sotaro Katsui, Masato Nishizawa, Hiroyuki Uetake
    • Journal Title

      Annals of Thoracic and Cardiovascular Surgery

      Volume: 26 Issue: 6 Pages: 352-358

    • DOI

      10.5761/atcs.oa.19-00300

    • NAID

      130007958402

    • ISSN
      1341-1098, 2186-1005
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【下肢閉塞性動脈硬化症-最新の診断と治療を知る】外科的治療2020

    • Author(s)
      猪狩 公宏, 工藤 敏文
    • Journal Title

      カレントテラピー

      Volume: 38 Pages: 37-42

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【動脈硬化診療のすべて】(III章)動脈硬化の診断 機能検査 ABIとPWV2019

    • Author(s)
      加賀山 知子, 工藤 敏文
    • Journal Title

      日本医師会雑誌

      Volume: 148特別2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of the Severity of Ischaemia and the Outcomes of Revascularisation in Peripheral Arterial Disease Patients Based on the Skin Microcirculatory Response to a Thermal Load Test.2019

    • Author(s)
      Yamamoto Y, Inoue Y, Igari K, Toyofuku T, Kudo T, Uetake H
    • Journal Title

      EJVES Short Rep

      Volume: 42 Pages: 21-25

    • DOI

      10.1016/j.ejvssr.2018.12.003

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retrospective study on laser treatment of oral vascular lesions using the "leopard technique": The multiple spot irradiation technique with a single-pulsed wave2018

    • Author(s)
      Miyazaki H, Ohshiro T, Romeo U, Noguchi T, Maruoka Y, Gaimari G, Tomov G, Wada Y,
    • Journal Title

      Photomed Laser Surg

      Volume: 36 Issue: 6 Pages: 320-325

    • DOI

      10.1089/pho.2017.4410

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In Patients with Severe Peripheral Arterial Disease, Revascularization-Induced Improvement in Lower Extremity Ischemia Can Be Detected by Laser Speckle Contrast Imaging of the Fluctuation in Blood Perfusion after Local Heating.2018

    • Author(s)
      Katsui S, Inoue Y, Yamamoto Y, Igari K, Kudo T, Uetake H.
    • Journal Title

      Ann Vasc Surg

      Volume: 48 Pages: 67-74

    • DOI

      10.1016/j.avsg.2017.09.022

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel assessment tool based on laser speckle contrast imaging to diagnose severe ischemia in the lower limb for patients with peripheral arterial disease2017

    • Author(s)
      Katsui S, Inoue Y, Igari K, Toyofuku T, Kudo T, Uetake H
    • Journal Title

      Lasers Surg Med

      Volume: 49 Issue: 7 Pages: 645-651

    • DOI

      10.1002/lsm.22669

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of the Lateral Thoracic Artery in Pectoralis Major Musculocutaneous Flap Reconstruction: Quantitative Assessment of Blood Circulation Using Indocyanine Green Angiography2017

    • Author(s)
      Miyazaki H, Igari K, Kudo T, Iwai T, Wada Y, Takahashi Y, Inoue Y, Asamura S.
    • Journal Title

      Ann Plast Surg

      Volume: 79 Issue: 5 Pages: 498-504

    • DOI

      10.1097/sap.0000000000001123

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The evaluation of contralateral foot circulation after unilateral revascularization procedures using indocyanine green angiography2017

    • Author(s)
      Nakamura M, Igari K, Toyofuku T, Kudo T, Inoue Y, Uetake H
    • Journal Title

      Sci Rep

      Volume: 23 Issue: 1 Pages: 16171-16171

    • DOI

      10.1038/s41598-017-16527-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Comparison of the Regional Circulation in the Feet between Dialysis and Non-Dialysis Patients using Indocyanine Green Angiography.2016

    • Author(s)
      Nishizawa M, Igari K, Kudo T, Toyofuku T, Inoue Y, Uetake H.
    • Journal Title

      Scand J Surg

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 大胸筋皮弁は安全性の高いリカバリー皮弁か?2018

    • Author(s)
      宮﨑英隆、和田仁孝、玉川俊次、上野一樹、平岡政信、久米川真治、保富宗城、朝村真一
    • Organizer
      第61回日本形成外科学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Treatment strategies for oral vascular anomalies: Approaches to massive lesions using intralesional laser photocoagulation.2017

    • Author(s)
      Hidetaka Miyazaki, Yoshitaka Wada, Kae Tanaka, Hiroyuki Harada, Shinichi Asamura
    • Organizer
      European Congress of Laser Dentistry 2017
    • Place of Presentation
      プロブディフ(ブルガリア)
    • Year and Date
      2017-03-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Treatment strategies for large oral vascular anomalies using intralesional laser photocoagulation.2016

    • Author(s)
      Hidetaka Miyazaki, Umberto Romeo, Yoshitaka Wada, Junji Kato, Kae Tanaka, Alessandro Del Vecchio, Yutaka Maruoka, Hisashi Watanabe, Hiroyuki Harada, Shinichi Asamura
    • Organizer
      15th Congress of World Federation of Laser Dentistry
    • Place of Presentation
      名古屋
    • Year and Date
      2016-07-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Treatment of oral vascular malformations using a long pulsed Nd:YAG laser2016

    • Author(s)
      Kawachi Naoko, Hidetaka Miyazaki, Yoshitaka Wada, Yoshiro Saito, Sayaka Yoshiba, Yuji Kurihara, Tetsuo Shirota
    • Organizer
      15th Congress of World Federation of Laser Dentistry
    • Place of Presentation
      名古屋
    • Year and Date
      2016-07-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2023-12-25  

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