effect of vasopressin on lidocaine distribution, anesthetic effect and circulatory dynamics

• Project/Area Number: 16K11768
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: The Nippon Dental University
• Principal Investigator: SUNADA KATSUHISA 日本歯科大学, 生命歯学部, 教授 (50171286)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: バソプレシン / リドカイン / 歯科用局所麻酔薬 / 麻酔効果 / 循環動態 / 局所麻酔 / 血管収縮薬 / 麻酔作用 / 局所麻酔薬 / 歯科麻酔 / レーザードップラー血流計 / テイルカフ法 / 体性感覚誘発電位 / 歯学

Outline of Final Research Achievements

In this study, we aimed to investigate the anesthetic effect of vasopressin-added local anesthetics. Vasopressin was added to lidocaine, a local anesthetic, and it was administered into the oral cavity of rats to determine its effect on anesthetic effect and cardiovascular changes. Furthermore, the tissue distribution of the lidocaine was also examined using radioactive isotopes. As a result, local administration to oral cavity of 0.03 U / ml vasopressin-added lidocaine reduced tissue blood flow. In addition, it became clear that the anesthetic action was enhanced, duration of tissue localization was prolonged, and hemodynamics was not affected. Therefore, it was thought that vasopressin could be became a useful local anesthetic additive instead of adrenaline.

Academic Significance and Societal Importance of the Research Achievements

歯科では、十分な効果を得るためにアドレナリンを含んだ局所麻酔薬が頻用されている。一方、高齢化社会の到来に伴って、循環器疾患患者が治療を受ける機会が激増している。これらの患者に対するアドレナリン含有麻酔薬の投与は、血圧上昇や不整脈の原因となる。そこで、循環器に対する影響が小さいバソプレシンの有効性について検討した。その結果バソプレシンは、アドレナリンに代わる有用な局所麻酔添加薬になり得る可能性が示唆された。

Research Products

• [Presentation] バソプレシンがリドカインの麻酔作用と循環動態に与える影響 (2018)
  • Author(s): 村田奈保子、橋本修一、砂田勝久
  • Organizer: 第47回日本歯科麻酔学会
• [Presentation] Effect of circulatory dynamics of vasopressin injected into the oral cavity (2018)
  • Author(s): Naoko Murata, Katsuhisa Sunada
  • Organizer: International association of dental research
  • Int'l Joint Research
• [Presentation] Effect of circulatory dynamics of vasopressin injected into the oral cavity (2018)
  • Author(s): Nahoko Murata, Katsuhisa Sunada
  • Organizer: international association of dental research
  • Int'l Joint Research
• [Presentation] Effect of vasopressin in local anesthesia on peripheral blood flow (2018)
  • Author(s): Keiko Morimoto, Katsuhisa Sunada
  • Organizer: international association of dental research
  • Int'l Joint Research
• [Presentation] Evaluation of Levobupivacaine with Dexmedetomidine for Infiltration Anesthesia in Rats (2017)
  • Author(s): Kenichirou Shinohara, Sari Ishi, Katsuhisa Sunada
  • Organizer: The 95th International Association of Dental Research
  • Place of Presentation: San Francisco
  • Year and Date: 2017-03-22
  • Int'l Joint Research
• [Presentation] バソプレシンが粘膜血流量、循環動態およびリドカインの麻酔効果に与える影響 (2017)
  • Author(s): 村田奈保子、橋下修一、砂田勝久
  • Organizer: 日本歯科麻酔学会
• [Presentation] メピバカインの組織内動態に及ぼすバソプレシンの効果 (2017)
  • Author(s): 森本惠子、橋下修一、砂田勝久
  • Organizer: 日本歯科麻酔学会