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Feed-forward cardiorespiratory control mechanism by higher brain center plays a significant role in enhancing physiological efficiency to dynamic exercise

Research Project

Project/Area Number 16K13023
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionMorinomiya University of Medical Sciences

Principal Investigator

Miyamoto Tadayoshi  森ノ宮医療大学, 保健医療学部, 教授 (40294136)

Co-Investigator(Kenkyū-buntansha) 上田 真也  岐阜大学, 教育学部, 准教授 (40616926)
中原 英博  森ノ宮医療大学, 保健医療学部, 教授 (90514000)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords高位中枢 / フィードフォワード制御 / 分時換気量 / セントラルコマンド / 高強度運動 / 予測制御 / 循環 / 心拍数 / 高次脳機能 / 予測的・見込み的制御 / 循環調節 / 呼吸調節 / 運動強度 / 血中乳酸 / 血中カテコラミン / 運動 / 回復 / 呼吸循環 / システム解析 / j呼吸
Outline of Final Research Achievements

The purpose of this study was to investigate the predictive control of respiratory and circulatory systems during the pre-exercise period. Protocol 1. Eleven healthy males underwent a 10-min seated rest period which followed by an ergometer bicycle exercise for 2 min at the different intensities (Preparatory-Go trial). Protocol 2. Eleven subjects were informed to pedal the bicycles, but the exercise onset sudden came during the middle of rest period (Non Preparatory-Go trial). During exercise period, a comparison between the Preparatory-Go and Non Preparatory-Go trials revealed significantly lower HR and mean blood pressure, and higher VE and blood lactic acid concentration for the Non Preparatory-Go trial. In conclusion, a preparatory neural control of cardio-respiratory system by the higher brain center plays a significant role in determining the dynamic cardiorespiratory response during higher intensity exercise, and in enhancing physiological efficiency to exercise.

Academic Significance and Societal Importance of the Research Achievements

高位中枢神経系の予測・見込み制御が運動時の生体応答の時間的遅れを補償するきわめて重要な生理的機構であることが判明した。これにより陸上のスタート直前や、球技のような突然の運動開始が連続するような場面で高いパフォーマンス発揮が可能な、新しい生理心理学的トレーニング法の開発などスポーツ現場に変革をもたらす可能性がある。また、医学と工学の融合を目指すバイオニック医療分野においては、高次脳機能フィードフォワード制御の要素を備えた人工循環中枢の論理インターフェイスの開発にも役立つ。さらに、リハビリテーション分野においては、高位中枢神経系にアプローチする過去例にない新規運動療法の開発につながる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (40 results)

All 2019 2018 2017 2016

All Journal Article (18 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 8 results) Presentation (20 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] Development of an anaesthetized-rat model of exercise hyperpnoea: an integrative model of respiratory control using an equilibrium diagram2018

    • Author(s)
      Miyamoto T, Manabe K, Ueda S, Nakahara H.
    • Journal Title

      Exp Physiol

      Volume: 103 Issue: 5 Pages: 748-760

    • DOI

      10.1113/ep086850

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamic cerebral autoregulation during cognitive task: Effect of hypoxia.2018

    • Author(s)
      Ogoh S, Nakata H, Miyamoto T, Bailey DM, Shibasaki M.
    • Journal Title

      J Appl Physiol

      Volume: 124 Issue: 6 Pages: 1413-1419

    • DOI

      10.1152/japplphysiol.00909.2017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ivabradine does not acutely affect open-loop baroreflex static characteristics and spares sympathetic heart rate control in rats2018

    • Author(s)
      Yamamoto Hiromi、Kawada Toru、Shimizu Shuji、Uemura Kazunori、Inagaki Masashi、Kakehi Kazuyoshi、Iwanaga Yoshitaka、Fukuda Kanji、Miyamoto Tadayoshi、Miyazaki Shunichi、Sugimachi Masaru
    • Journal Title

      International Journal of Cardiology

      Volume: 257 Pages: 255-261

    • DOI

      10.1016/j.ijcard.2017.11.115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of walking in water on gut hormone concentrations and appetite: comparison with walking on land2018

    • Author(s)
      Ueda S, Nakahara H, Kawai E, Usui T, Tsuji S, Miyamoto T.
    • Journal Title

      Endocr Connect

      Volume: 7 Issue: 1 Pages: 97-106

    • DOI

      10.1530/ec-17-0323

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Significant role of feedforward cardiorespiratory control by higher brain center to dynamic exercise2018

    • Author(s)
      Miyamoto T, Ito Go, Nakahara H.
    • Journal Title

      Proc Life Engineering

      Volume: 18 Pages: 124-129

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Effects of acupuncture-induced bradycardia on heart rate responses during osture change and high intensity exercise.2018

    • Author(s)
      Nakahara H, Ueda S, Kawai E, Higashiura R, Miyamoto T.
    • Journal Title

      Proc Life Engineering

      Volume: 18 Pages: 130-134

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Cardiorespiratory adaptation induced by low-frequency sever-intensity interval training2018

    • Author(s)
      Ito Go, Nakahara H, Miyamoto T.
    • Journal Title

      Proc Life Engineering

      Volume: 18 Pages: 135-140

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Quantitative analysis of respiratory control during exercise: Development of a rat model of mimicked exercise under anesthesia.2017

    • Author(s)
      Miyamoto T, Kawada T, Ueda S. Nakahara H.
    • Journal Title

      FASEB J

      Volume: 31

    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Effects of acute hypoxia on human cognitive processing: a study using ERPs and SEPs2017

    • Author(s)
      Nakata Hiroki、Miyamoto Tadayoshi、Ogoh Shigehiko、Kakigi Ryusuke、Shibasaki Manabu
    • Journal Title

      Journal of Applied Physiology

      Volume: 123 Issue: 5 Pages: 1246-1255

    • DOI

      10.1152/japplphysiol.00348.2017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peripheral versus central effect of intravenous moxonidine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation2017

    • Author(s)
      Kawada Toru、Shimizu Shuji、Yamamoto Hiromi、Miyamoto Tadayoshi、Shishido Toshiaki、Sugimachi Masaru
    • Journal Title

      Life Sciences

      Volume: 190 Pages: 103-109

    • DOI

      10.1016/j.lfs.2017.09.038

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 時系列パラメトリック法を用いた人における呼吸化学受容器反射機能の同定.2017

    • Author(s)
      西崎晶子, 朔啓太, 遠山岳詩, 吉田賢明, 西川拓也, 筒井裕之, 宮本忠吉, 砂川賢二.
    • Journal Title

      心臓リハビリテーション

      Volume: 23 Pages: 62-68

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of different input pressure waveforms on the carotid sinus baroreflex-mediated sympathetic arterial pressure response in rats2017

    • Author(s)
      Kawada Toru、Shimizu Shuji、Yamamoto Hiromi、Miyamoto Tadayoshi、Kamiya Atsunori、Shishido Toshiaki、Sugimachi Masaru
    • Journal Title

      Journal of Applied Physiology

      Volume: 123 Issue: 4 Pages: 914-921

    • DOI

      10.1152/japplphysiol.00354.2017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Central Chemoreflex activation induces sympatho-excitation without altering static or dynamic baroreflex function in normal rats.2017

    • Author(s)
      Saku K, Tohyama T, Shinoda M, Kishi T, Hosokawa K, Nishikawa T, Oga Y, Sakamoto T, Tsutsui H, Miyamoto T, Sunagawa K.
    • Journal Title

      Physiol Rep.

      Volume: 5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 高位中枢を介した予測・見込み的制御がStep負荷運動時の呼吸循環代謝動態に及ぼす影響2016

    • Author(s)
      宮本忠吉、中原英博、外林大輔、上田真也
    • Journal Title

      日本循環制御医学会総会プログラム・抄録集

      Volume: 37 Pages: 40-40

    • Related Report
      2016 Research-status Report
  • [Journal Article] 健康と自律神経機能 バイタルサインを決定する呼吸循環調節機序2016

    • Author(s)
      宮本 忠吉
    • Journal Title

      Health and Behavior Sciences

      Volume: 15 Pages: 25-25

    • Related Report
      2016 Research-status Report
  • [Journal Article] システム制御理論を用いた呼吸化学調節系の動的フィードバック制御機能の定量評価.2016

    • Author(s)
      宮本忠吉、上田真也、真鍋幸、河合英理子、中原英博
    • Journal Title

      森ノ宮医療大学紀要

      Volume: 9,10 Pages: 107-116

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] System physiology of respiratory control in man2016

    • Author(s)
      Miyamoto T.
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 5 Issue: 5 Pages: 329-337

    • DOI

      10.7600/jpfsm.5.329

    • NAID

      130005279677

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2016 Research-status Report
    • Open Access
  • [Journal Article] A systems analysis approach to understanding respiratory control in humans.2016

    • Author(s)
      Miyamoto T.
    • Journal Title

      Proc Life Engineering

      Volume: 16 Pages: 15-18

    • Related Report
      2016 Research-status Report
  • [Presentation] Dynamic cerebral carbon dioxide reactivity at rest and during exercise.2019

    • Author(s)
      Ogoh S, Shibata S, Nakahara H, MiyamotoT.
    • Organizer
      Experimental Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Power Spectral Analysis of Short-Term Blood Pressure Recordings for Assessing Daily Variations of Blood Pressure in Human.2018

    • Author(s)
      Kinoshita H, Mannoji H, Saku K, Mano J, MiyamotoT, Todaka K, Kishi T, Kanaya S, Sunagawa K.
    • Organizer
      40th Annual international Conference of the IEEEE Engineering in Medicine and Bilogy Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高強度運動開始前の準備期における呼吸循環系フィードフォワード制御の生理学的役割.2018

    • Author(s)
      宮本忠吉,外林大輔,伊藤剛,上田真也,中原英博
    • Organizer
      第72回日本体力医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 運動準備期の高位中枢を介したフィードフォワード制御が運動に対する呼吸・循環系応答のダイナミクスに及ぼす影響.2018

    • Author(s)
      宮本忠吉,外林大輔,伊藤剛,上田真也,中原英博.
    • Organizer
      計測自動制御学会ライフエンジニアリング部門シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 工学的枠組みによるシミュレーションを用いた慢性心不全患者における周期性呼吸発生機序の検証2018

    • Author(s)
      遠山岳詩, 朔啓太, 宮本忠吉, 筒井裕之, 砂川賢二
    • Organizer
      第24回日本心臓リハビリテーション学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Exercise Intensity-dependent Predictive Control of Respiratory and Circulatory Systems in humans2018

    • Author(s)
      Miyamoto T, Ito G, Ueda S, Nakahara H.
    • Organizer
      第81回日本生体医工学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 運動前の高位中枢による予測的・見込み的呼吸循環制御は運動負荷強度に依存する.2018

    • Author(s)
      宮本忠吉,外林大輔,伊藤剛,上田真也,中原英博,川田徹,稲垣正司,杉町勝
    • Organizer
      第39回日本循環制御医学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Exercise Intensity-dependent Predictive Control of Respiratory and Circulatory Systems in humans.2018

    • Author(s)
      Miyamoto T, Ito G, Ueda S, Nakahara H.
    • Organizer
      第81回日本生体医工学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 運動前の高位中枢による予測的・見込み的呼吸循環制御は運動負荷強度に依存する.2018

    • Author(s)
      宮本忠吉、外林大輔、伊藤剛、上田真也、中原英博、川田徹、稲垣正司、杉町勝
    • Organizer
      第39回日本循環制御医学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Feed-Forward Cardiorespiratory Control Mechanism by Higher Brain Center Plays a Significant Role in Enhancing Physiological Efficiency to dynamic Exercise.2017

    • Author(s)
      Miyamoto T, Nakahara H.
    • Organizer
      日本循環器学会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Quantitative analysis of respiratory control during exercise: Development of a rat model of mimicked exercise under anesthesia.2017

    • Author(s)
      Miyamoto T, Nakahara H, Ueda S, Kawada T.
    • Organizer
      Experimental Biology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cognitive task impairs dynamic cerebral autoregulation during normoxia and hypoxia.2017

    • Author(s)
      Ogoh S, Nakata H, Miyamoto T, Shibasaki M.
    • Organizer
      AMERICAN COLLEGE OF SPORTS MEDICINE 63TH ANNUAL MEETING
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Human Cognitive functions during acute hypoxic exposure.2017

    • Author(s)
      Shibasaki M, Ogoh S, Miyamoto T Nakata H.
    • Organizer
      AMERICAN COLLEGE OF SPORTS MEDICINE 63TH ANNUAL MEETING,
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of an anesthetized rat model of mimicked exercise-analytical approach to underlying mechanism of ventilatory abnormality in Heart Failure-.2017

    • Author(s)
      Miyamoto T, Nakahara H.
    • Organizer
      第81回日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Feed-Forward Cardiorespiratory Control Mechanism by Higher Brain Center Plays a Significant Role in Enhancing Physiological Efficiency to dynamic Exercise.2017

    • Author(s)
      Miyamoto T, Nakahara H
    • Organizer
      第81回日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Acupoint Dependence of Depressor and Bradycardic Effects of Manual Acupuncture Stimulation in Human.2017

    • Author(s)
      Nakahara H, Kawai E, Miyamoto T
    • Organizer
      第81回日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] A systems analysis approach to integrated responses in the respiratory system.2016

    • Author(s)
      Miyamoto T, Nakahara H.
    • Organizer
      ライフエンジニアリング学会
    • Place of Presentation
      大阪
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] バイタルサインを決定する呼吸循環調節機序2016

    • Author(s)
      宮本忠吉
    • Organizer
      日本健康行動科学会第14回学術大会シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2016-09-10
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 高位中枢を介した予測・見込み的制御がStep負荷運動時の呼吸循環代謝動態に及ぼす影響2016

    • Author(s)
      宮本忠吉
    • Organizer
      日本循環制御医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Analytical and quantitative approach to underlying mechanism of respiratory control at rest and during exercise in humans2016

    • Author(s)
      Miyamoto T, Ueda S, Kawai E, Nakahara H.
    • Organizer
      第55回日本生体医工学会大会
    • Place of Presentation
      富山
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Book] 体育の科学 「運動時の循環調節の探索と新しい発見を知る」, -循環調節のシステムバイオロジー-2018

    • Author(s)
      宮本 忠吉
    • Total Pages
      7
    • Publisher
      杏林書院
    • Related Report
      2018 Annual Research Report
  • [Book] 「運動生理学分野における呼吸循環研究の最前線」, -運動時の呼吸調節-2018

    • Author(s)
      宮本 忠吉
    • Total Pages
      10
    • Publisher
      「循環制御」
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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