Feed-forward cardiorespiratory control mechanism by higher brain center plays a significant role in enhancing physiological efficiency to dynamic exercise
| Project/Area Number |
16K13023
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Morinomiya University of Medical Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
上田 真也 岐阜大学, 教育学部, 准教授 (40616926)
中原 英博 森ノ宮医療大学, 保健医療学部, 教授 (90514000)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 高位中枢 / フィードフォワード制御 / 分時換気量 / セントラルコマンド / 高強度運動 / 予測制御 / 循環 / 心拍数 / 高次脳機能 / 予測的・見込み的制御 / 循環調節 / 呼吸調節 / 運動強度 / 血中乳酸 / 血中カテコラミン / 運動 / 回復 / 呼吸循環 / システム解析 / ｊ呼吸 |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the predictive control of respiratory and circulatory systems during the pre-exercise period. Protocol 1. Eleven healthy males underwent a 10-min seated rest period which followed by an ergometer bicycle exercise for 2 min at the different intensities (Preparatory-Go trial). Protocol 2. Eleven subjects were informed to pedal the bicycles, but the exercise onset sudden came during the middle of rest period (Non Preparatory-Go trial). During exercise period, a comparison between the Preparatory-Go and Non Preparatory-Go trials revealed significantly lower HR and mean blood pressure, and higher VE and blood lactic acid concentration for the Non Preparatory-Go trial. In conclusion, a preparatory neural control of cardio-respiratory system by the higher brain center plays a significant role in determining the dynamic cardiorespiratory response during higher intensity exercise, and in enhancing physiological efficiency to exercise.
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| Academic Significance and Societal Importance of the Research Achievements |
高位中枢神経系の予測・見込み制御が運動時の生体応答の時間的遅れを補償するきわめて重要な生理的機構であることが判明した。これにより陸上のスタート直前や、球技のような突然の運動開始が連続するような場面で高いパフォーマンス発揮が可能な、新しい生理心理学的トレーニング法の開発などスポーツ現場に変革をもたらす可能性がある。また、医学と工学の融合を目指すバイオニック医療分野においては、高次脳機能フィードフォワード制御の要素を備えた人工循環中枢の論理インターフェイスの開発にも役立つ。さらに、リハビリテーション分野においては、高位中枢神経系にアプローチする過去例にない新規運動療法の開発につながる可能性がある。
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Central Chemoreflex activation induces sympatho-excitation without altering static or dynamic baroreflex function in normal rats.2017
Author(s)
Saku K, Tohyama T, Shinoda M, Kishi T, Hosokawa K, Nishikawa T, Oga Y, Sakamoto T, Tsutsui H, Miyamoto T, Sunagawa K.
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Journal Title
Related Report
Peer Reviewed / Open Access
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