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Research on the relationship between prenatal fetal sleep formation and sleep disorder in children

Research Project

Project/Area Number 16K13072
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Childhood science (childhood environment science)
Research InstitutionKyushu University

Principal Investigator

Morokuma Seiichi  九州大学, 医学研究院, 教授 (50380639)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords胎児行動 / 睡眠 / 発達 / 胎児
Outline of Final Research Achievements

Sleep during the developmental period is important for neural network formation and epidemiological research indicates that children's sleep disorders may lead to adult depression and schizophrenia. On the other hand, It has been reported that the origin of depression, schizophrenia and neurodevelopmental disorders exist in the fetal period. Although neurodevelopment has already begun from the fetal stage, there have been no studies on the relationship between fetal sleep formation and sleep disorders in children. In this study, the primary purpose was to clarify changes in eye movement activity during the prenatal period, and two significant critical points were revealed. Currently, we are analyzing the association between fetal eye movement activity and children's sleep disorder.

Academic Significance and Societal Importance of the Research Achievements

本研究により、胎児の睡眠は有意な変曲点をもって発達していることが明らかとなった。このことは、ヒトの睡眠形成を知る上で有用な知見となり、胎児の発達をみる指標の一つとなることが考えられる。今後、胎児期の睡眠形成に影響を及ぼす因子の検討にも有用である。また、現在解析中であるが、子どもの睡眠障害との関連が明らかになれば、子どもの睡眠障害の原因分析にも繋がる。以上のように、本研究は学術的、社会的意義が大きいと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] Simplified wide-Range ultrasonic measurements using the sensor three-Dimensional system2018

    • Author(s)
      Morokuma Seiichi、Maehara Kana、Okawa Hikohiro、Kato Kiyoko、Mine Yoshitaka、Nakauchi Shouichi
    • Journal Title

      Journal of Medical Ultrasound

      Volume: 26 Issue: 2 Pages: 100-102

    • DOI

      10.4103/jmu.jmu_17_18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-reassuring foetal status and neonatal irritability in the Japan Environment and Children’s Study: A cohort study2018

    • Author(s)
      Morokuma Seiichi、Michikawa Takehiro、Kato Kiyoko、Sanefuji Masafumi、Shibata Eiji、Tsuji Mayumi、Senju Ayako、Kawamoto Toshihiro、Ohga Shouichi、Kusuhara Koichi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 15853-15853

    • DOI

      10.1038/s41598-018-34231-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eye movement activity in normal human fetuses between 24 and 39 weeks of gestation2017

    • Author(s)
      33.Okawa H, Morokuma S, Maehara K, Horinouchi T, Arata A, Konishi Y, Kato K.
    • Journal Title

      PLoS One

      Volume: 12;12(7) Issue: 7 Pages: 178722-178722

    • DOI

      10.1371/journal.pone.0178722

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] FGRにおける胎児行動の変化と評価2016

    • Author(s)
      諸隈誠一, 前原佳奈, 大川彦宏, 加藤聖子
    • Journal Title

      臨床婦人科産科

      Volume: 70 Pages: 894-898

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] 胎児期の体内時計と睡眠発達2018

    • Author(s)
      諸隈誠一
    • Organizer
      第121回日本小児科学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 妊娠期の環境が周産期予後・次世代に与える影響に関する研究2018

    • Author(s)
      諸隈誠一
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胎児の生体周期から見た脳の発達2017

    • Author(s)
      諸隈誠一
    • Organizer
      日本小児神経学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 胎児期からのハイリスク児の臨床観察による発達障害理解と包括的診断法2016

    • Author(s)
      諸隈誠一
    • Organizer
      日本発達神経科学学会
    • Place of Presentation
      東京大学
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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