| Project/Area Number |
16K15033
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 間葉系幹細胞 / プリオン病 / 神経変性疾患 / 自然免疫 / 治療効果 / 獣医学 / 感染症 / 脳神経疾患 / 再生医療 / プリオン |
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| Outline of Final Research Achievements |
Intra-cerebral transplantation of compact bone-derived MSCs (CB-MSCs) prolonged survival of prion-infected mice, suggesting that CB-MSCs could be useful for the treatment of neurodegenerative disorders. In the CB-MSCs transplanted prion-infected mice, unexpectedly, microglia were more activated than un-transplanted mice. However, up-regulation of some of the marker genes for M2-type microglia, such as Arg-1, suggesting that CB-MSCs modify the activation state of microglia. The culture supernatant of CB-MSCs also shifted the activation state of microglia recovered from prion-infected mice to M2-type activation state. These results suggest that the alteration of innate immunity by CB-MSCs is one of the mechanisms for the therapeutic effects of CB-MSCs on neurodegenerative disorders.
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