Analyses of endothelial cell dynamics in retinal angiogenesis
| Project/Area Number |
16K15737
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
Uemura Akiyoshi 名古屋市立大学, 大学院医学研究科, 教授 (30373278)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
西山 功一 熊本大学, 医学部附属病院, その他 (80398221)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MIURA Takashi 九州大学, 大学院医学研究院, 教授 (10324617)
TERO Atsushi 九州大学, マス・フォア・インダストリ研究所, 准教授 (60431326)
MIYATA Takaki 名古屋大学, 医学系研究科, 教授 (70311751)
|
|---|
| Research Collaborator |
Kim Pilhan
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 網膜 / マウス / イメージング / 数理モデル / 内皮細胞 / ペリサイト / マクロファージ / 生体イメージング / 網膜血管 / 網膜新生血管 / ダイナミクス |
|---|
| Outline of Final Research Achievements |
For the real-time monitoring of cell dynamics in live mouse retinas, we have developed an intravital imaging system utilizing confocal or two-photon laser scanning fluorescence microscopy. By exploiting this system, we successfully detected abnormalities in macrophage dynamics in pericyte-deficient mouse retinas following injections of an anti-PDGFRβ antibody, which reproduced characteristic features of human diabetic retinopathy. These achievements will contribute to elucidating dynamic movements of various types of retinal cells, including neurons, glial cells, and endothelial cells, under physiological and pathological conditions.
|
Report
(3 results)
Research Products
(14 results)
-
-
-
-
[Journal Article] Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown2017
Author(s)
Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro-Oonuma T, Hwang Y, Ahn S, Park I, Ikeda W, Kusuhara S, Fukushima Y, Nara H, Sakai H, Fujiwara T, Matsushita J, Ema M, Hirashima M, Minami T, Shibuya M, Takakura N, Kim P, Miyata T, Ogura Y, Uemura A
-
Journal Title
JCI Insight
Volume: 2
Issue: 3
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
[Presentation] 糖尿病網膜症の病態・生理2016
Author(s)
植村明嘉
Organizer
第59回日本糖尿病学会シンポジウム
Place of Presentation
国立京都国際会館（京都府京都市）
Year and Date
2016-05-21
Related Report
Invited
-
