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Study on epigenetic markers for diabetes risk indicating the personal history of postprandial hyperglycemia

Research Project

Project/Area Number 17H01969
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits
Research InstitutionUniversity of Shizuoka

Principal Investigator

GODA Toshinao  静岡県立大学, 食品栄養科学部, 教授 (70195923)

Co-Investigator(Kenkyū-buntansha) 市川 陽子  静岡県立大学, 食品栄養科学部, 教授 (50269495)
新井 英一  静岡県立大学, 食品栄養科学部, 教授 (60325256)
望月 和樹  山梨大学, 大学院総合研究部, 教授 (80423838)
本間 一江  静岡県立大学, 食品栄養科学部, 助教 (80724765)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords糖尿病 / 食後高血糖 / エピゲノム / バイオマーカー / 慢性炎症
Outline of Final Research Achievements

We have demonstrated that the peripheral leukocytes exposed to a high glucose concentration showed elevated levels of inflammation-related genes as well as the increases in the mRNA abundance of DNA methyltransferases along with a decrease in DNA methylation (epigenetic regulation) of inflammation-related genes. Among a number of microRNAs expressed in mononuclear cells, three microRNAs including miR-320a, which has been shown to regulate the expression of IL-1b receptor and TNF receptor-regulatory proteins, were found to be markedly reduced in the expression level in the cells as well as in the secreted level in the culture media. These results suggest that microRNAs derived from leukocytes are possible candidates of the biomarkers for the history of postprandial glucose spikes.

Academic Significance and Societal Importance of the Research Achievements

本研究により、食後高血糖や肥満をもたらす食習慣を改善することの意義が、エピゲノムの変化を介した慢性炎症の抑制およびインスリン抵抗性の改善の観点から、説明できるようになった。慢性代謝性疾患のリスクを示すバイオマーカーが明確になったため、それを指標にして、個人ごとに食事のあり方を提案することが理論的には可能となった。食後高血糖と肥満を抑制し、それに起因する炎症の慢性化を抑制することは、日本人における糖尿病などの生活習慣病のリスクを低減させることにつながるものと考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (42 results)

All 2020 2019 2018 2017 Other

All Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 14 results,  Open Access: 10 results) Presentation (23 results) (of which Int'l Joint Research: 7 results,  Invited: 8 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Sustained effects of resistant starch on the expression of genes related to carbohydrate digestion/absorption in the small intestine.2020

    • Author(s)
      Rosas-Perez AM, Honma K, Goda T
    • Journal Title

      Int J Food Sci Nutr.

      Volume: Jan 24 Issue: 5 Pages: 1-9

    • DOI

      10.1080/09637486.2019.1711362

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic regulation of resistant starch in the expression of genes related to the absorption/digestion of carbohydrates2020

    • Author(s)
      Rosas-Perez Aratza Mireya, Honma Kazue, Goda Toshinao
    • Journal Title

      Current Studies in Nutrition and Food Science

      Volume: 1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glucose and TNF enhance expression of TNF and IL1B, and histone H3 acetylation and K4/K36 methylation, in juvenile macrophage cells2020

    • Author(s)
      Honma Kazue, Machida Chie, Mochizuki Kazuki, Goda Toshinao
    • Journal Title

      GENE: X

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Undernutrition in Pregnant Rats Induces Glucose Intolerance with Enhanced Expression of Inflammation-Related Genes in Peripheral Leukocytes of the Offspring2019

    • Author(s)
      Jin F, Honma K, Mochizuki K, Goda T.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 65 Issue: 6 Pages: 534-540

    • DOI

      10.3177/jnsv.65.534

    • NAID

      130007777895

    • ISSN
      0301-4800, 1881-7742
    • Year and Date
      2019-12-31
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic regulation of lipoprotein lipase gene via BRD4, which is potentially associated with adipocyte differentiation and insulinresistance.2019

    • Author(s)
      Inoue T, Hariya N, Imamochi Y, Dey A, Ozato K, Goda T, Kubota T, Mochizuki K
    • Journal Title

      Eur J Pharmacol

      Volume: 858 Pages: 72492-72492

    • DOI

      10.1016/j.ejphar.2019.172492

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Supplementation with lower doses of EGCg reduces liver injury markers of type 2 diabetic rats2019

    • Author(s)
      Mochizuki Kazuki、Tan Yu、Uchiyama Yumiko、Suzuki Takuji、Hariya Natsuyo, Goda Toshinao
    • Journal Title

      Fundamental and Toxicological Sciences

      Volume: 6 Pages: 15-23

    • NAID

      130007584741

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The induction of CHD1 binding and methylation histone H3 K4 methylation on SI gene is associated with the gene expression in enterocyte-like Caco-2 cells.2018

    • Author(s)
      Mochizuki K, Osaki A, Inamochi Y, Goda T.
    • Journal Title

      OBM Genetics

      Volume: 2 Issue: 4 Pages: 1-1

    • DOI

      10.21926/obm.genet.1804046

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of the circadian rhythmic expression of Sglt1 in the mouse small intestine through histone acetylation and the mRNA elongation factor, BRD4-P-TEFb2018

    • Author(s)
      Yamauchi Hiroyuki、Honma Kazue、Mochizuki Kazuki、Goda Toshinao
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 印刷中 Issue: 7 Pages: 1-4

    • DOI

      10.1080/09168451.2018.1451743

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular regulations of mucosal maltase expressions.2018

    • Author(s)
      Goda Toshinao、Honma Kazue
    • Journal Title

      Journal of Pediatric Gastroenterology and Nutrition

      Volume: 66

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary Polyphenol Intake Estimated by 7-Day Dietary Records among Japanese Male Workers: Evaluation of the Within- and Between-Individual Variation2017

    • Author(s)
      Taguchi Chie, Kishimoto Yoshimi, Fukushima Yoichi, Saita Emi, Tanaka Miori, Takahashi Jinya, Masuda, Goda Toshinao, Kondo Kazuo
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 63 Issue: 3 Pages: 180-185

    • DOI

      10.3177/jnsv.63.180

    • NAID

      130005866074

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of the dietary carbohydrate?fat ratio on plasma phosphatidylcholine profiles in human and mouse2017

    • Author(s)
      Inoue Mizuki、Senoo Nanami、Sato Tomoki、Nishimura Yuri、Nakagawa Takumi、Miyoshi Noriyuki、Goda Toshinao、Morita Akihito、Miura Shinji
    • Journal Title

      The Journal of Nutritional Biochemistry

      Volume: 50 Pages: 83-94

    • DOI

      10.1016/j.jnutbio.2017.08.018

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene2017

    • Author(s)
      Sakurai Naoko、Inamochi Yuko、Inoue Takuya、Hariya Natsuyo、Kawamura Musashi、Yamada Masami、Dey Anup、Nishiyama Akira、Kubota Takeo、Ozato Keiko、Goda Toshinao、Mochizuki Kazuki
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 11962-11962

    • DOI

      10.1038/s41598-017-12342-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum gamma-glutamyltransferase is inversely associated with dietary total and coffee-derived polyphenol intakes in apparently healthy Japanese men2017

    • Author(s)
      Taguchi Chie、Kishimoto Yoshimi、Kondo Kazuo、Tohyama Kazushige、Goda Toshinao
    • Journal Title

      European Journal of Nutrition

      Volume: 印刷中 Issue: 8 Pages: 2819-2826

    • DOI

      10.1007/s00394-017-1549-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Combined Effects of Genetic Variation in the CNDP1 and CNDP2 Genes and Dietary Carbohydrate and Carotene Intake on Obesity Risk2017

    • Author(s)
      Yamakawa-Kobayashi Kimiko、Otagi Eri、Ohhara Yuya、Goda Toshinao、Kasezawa Nobuhiko、Kayashima Yasunari
    • Journal Title

      J Nutrigenet Nutrigenomics

      Volume: 10 Issue: 5-6 Pages: 146-154

    • DOI

      10.1159/000485798

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 小腸におけるスクロースの消化吸収関連遺伝子発現のエピジェネティック制御と生活習慣病発症との関連2019

    • Author(s)
      望月和樹、本間一江、竹田裕子、針谷夏代、合田敏尚
    • Organizer
      第73回日本栄養・食糧学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脂肪組織のインスリン抵抗性指標Adipo-IRから見た低グリセミックインデックス食の意義2019

    • Author(s)
      渡仲亮太、本間一江、金芳加、森翔平、佐橋徹、大槻尚子、市川陽子、合田敏尚
    • Organizer
      第73回日本栄養・食糧学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 代謝疾患予防のための早期分子指標2019

    • Author(s)
      3.望月和樹、針谷夏代、本間一江、竹田裕子、合田敏尚、久保田健夫
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 糖尿病モデルラットの末梢血白血球におけるDNAメチル化・脱メチル化関連遺伝子の発現と炎症関連遺伝子の発現変動との関連性2019

    • Author(s)
      石山詩織、瀧賀祐生、本間一江、合田敏尚
    • Organizer
      第62回糖尿病学会年次学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Relationship between postprandial glycemic response following low- and high-GI breakfast and inflammation-related gene expression2019

    • Author(s)
      渡仲亮太、金芳加、本間一江、森翔平、佐橋徹、大槻尚子、市川陽子、合田敏尚
    • Organizer
      Asian Association for the Study of Diabetes 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] インスリン抵抗性に対する栄養学的アプローチ2018

    • Author(s)
      合田敏尚、本間一江
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 食事要因による消化管機能の制御と代謝性疾患の予防に関する研究2018

    • Author(s)
      合田敏尚
    • Organizer
      第74回日本栄養・食糧学会中部支部大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 糖質の消化吸収を担う遺伝子の発現調節2018

    • Author(s)
      本間一江、合田敏尚
    • Organizer
      第49回日本消化吸収学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 新規転写伸長エピゲノム調節機構と胎生期低栄養による生活習慣病発症との関連2018

    • Author(s)
      望月和樹、針谷 夏代、本間 一江、合田 敏尚、久保田 健夫
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 小腸糖質消化吸収関連遺伝子の発現調節に及ぼすレジスタントスターチの持続的効果2018

    • Author(s)
      Aratza M. Rosas-Perez、本間一江、合田敏尚
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 末梢血白血球における炎症性サイトカイン遺伝子周辺のメチル化DNA検出方法の検討2018

    • Author(s)
      瀧賀祐生、金芳如、本間一江、合田敏尚
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 非肥満型2型糖尿病モデルGK ラットにおける膵臓機能に及ぼす胎児期低栄養の影響2018

    • Author(s)
      合田敏尚、金芳如、倉橋美帆、本間一江
    • Organizer
      第61回糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胎児期低栄養モデルラットにおける末梢血白血球の炎症性サイトカイン発現の変化2018

    • Author(s)
      金芳如、瀧賀祐生、本間一江、合田敏尚
    • Organizer
      第61回糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Sustained effect induced by resistant starch on the regulation of the expression of genes related with digestion/absorption of carbohydrates in the small intestine2018

    • Author(s)
      Aratza M. Rosas-Perez、本間一江、合田敏尚
    • Organizer
      American Society for Nutrition 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of resistant starch on the regulation of the expression of genes related with digestion/absorption of carbohydrates in the small intestine2018

    • Author(s)
      Aratza M. Rosas-Perez、本間一江、合田敏尚
    • Organizer
      The 4th International Conference on Pharma-Food (ICPF 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Epigenetic alterations of inflammation biomarkers related with the onset and development of diabetes and metabolic diseases2017

    • Author(s)
      合田敏尚
    • Organizer
      The 12th China-Japan International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 食事要因による消化管機能の制御と代謝性疾患の予防に関する研究2017

    • Author(s)
      合田敏尚
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Plasma TNF-α is associated with inflammation and nutrition status in community-dwelling Japanese elderly2017

    • Author(s)
      合田敏尚、麻植有希子
    • Organizer
      International Conference on Frailty & Sarcopenia Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] グルコース反復投与によるインスリン分泌応答およびインスリン作用の変化2017

    • Author(s)
      金芳如,倉橋美帆,本間一江,合田敏尚
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 非肥満型2型糖尿病モデルGKラットにおける膵臓機能に及ぼす胎児期低栄養の影響2017

    • Author(s)
      久保田美成,倉橋美帆,金芳加,本間一江,合田敏尚
    • Organizer
      第6回日本DOHaD学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Plasma alanine aminotransferase (ALT) activity is a reliable biomarker for the risk of insulin resistance and diabetes predisposition2017

    • Author(s)
      合田敏尚、本間一江、遠山和成、望月和樹
    • Organizer
      21st International Congress of Nutrition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fasting during the suckling-weaning transient period in rats induces metabolic abnormalities in adulthood2017

    • Author(s)
      本間一江、池田美沙、馬渡理子、望月和樹、合田敏尚
    • Organizer
      21st International Congress of Nutrition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of resistant starch on the expression of alpha-glucosidases in the small intestine-Persistence of the effect-2017

    • Author(s)
      Rosas-Perez Aratza、本間一江、合田敏尚
    • Organizer
      The 22th Shizuoka Forum on Health and Longevity
    • Related Report
      2017 Annual Research Report
  • [Book] 消化管からみた健康・栄養2018

    • Author(s)
      合田敏尚
    • Total Pages
      259
    • Publisher
      建帛社
    • ISBN
      9784767961972
    • Related Report
      2018 Annual Research Report
  • [Book] Handbook of Nutrition, Diet, and Epigenetics2017

    • Author(s)
      望月和樹、針谷夏代、本間一江、合田敏尚
    • Publisher
      Springer International Publishing
    • Related Report
      2017 Annual Research Report
  • [Remarks] 静岡県立大学教員データベース

    • URL

      http://db.u-shizuoka-ken.ac.jp/show/prof151.html

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 栄養生理学研究室HP

    • URL

      http://dfns.u-shizuoka-ken.ac.jp/labs/nutrphys

    • Related Report
      2018 Annual Research Report
  • [Remarks] 栄養生理学研究室HP

    • URL

      http://dfns.u-shizuoka-ken.ac.jp/labs/nutrphys/

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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