Elucidation of lipid molecular dynamics on three-dimensional minimal surface and development of innovative lipid cubic method
| Project/Area Number |
17H03038
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional solid state chemistry
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
ICHIKAWA Takahiro 東京農工大学, 工学(系)研究科(研究院), 准教授 (80598798)
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| Co-Investigator(Kenkyū-buntansha) |
渡辺 豪 北里大学, 理学部, 講師 (80547076)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | ジャイロイド / 液晶 / 脂質キュービック法 / 膜たんぱく質 / 膜タンパク質 / 双連続キュービック液晶 / モノオレイン / アトロプ異性体 / タンパク質結晶 / イオン液体 / シミュレーション / 自己組織化 / 計算科学 |
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| Outline of Final Research Achievements |
Precise analysis of the three-dimensional structures of various functional biopolymers is extremely important for understanding biological phenomena in the ecology. In this study, we focused on the further improvement of the "lipid cubic method", which is a method for producing such a single crystal of a biopolymer. In this method, we believe that it is essential to deeply understand and elucidate the bicontinuous cubic liquid crystals that are the medium of crystallization, and newly design and synthesize the molecules that form the liquid-crystalline phases. Their self-organizing behaviors were analyzed by making full use of experiments and simulations.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究を通して、双連続キュービック液晶に関する重要な設計指針を得ることができた。
得られた成果は目的通り『脂質キュービック法』の改良に有効である。しかし、双連続キュービック液晶が形成するジャイロイド構造は三次元の連続性を有するナノ構造であることを考えると、サイズ選択分離膜・電解質膜など多様な応用展開において劇的なイノベーションを生む可能性を秘めており、この液晶の理解は、学術的に意義深い。
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Report
(5 results)
Research Products
(38 results)
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[Book] 液晶2020
Author(s)
一川尚広
Total Pages
8
Publisher
液晶学会
Related Report
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[Book] 月刊化学2019
Author(s)
小林 翼、一川 尚広
Total Pages
5
Publisher
化学同人
Related Report
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