• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of lipid molecular dynamics on three-dimensional minimal surface and development of innovative lipid cubic method

Research Project

Project/Area Number 17H03038
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional solid state chemistry
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

ICHIKAWA Takahiro  東京農工大学, 工学(系)研究科(研究院), 准教授 (80598798)

Co-Investigator(Kenkyū-buntansha) 渡辺 豪  北里大学, 理学部, 講師 (80547076)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywordsジャイロイド / 液晶 / 脂質キュービック法 / 膜たんぱく質 / 膜タンパク質 / 双連続キュービック液晶 / モノオレイン / アトロプ異性体 / タンパク質結晶 / イオン液体 / シミュレーション / 自己組織化 / 計算科学
Outline of Final Research Achievements

Precise analysis of the three-dimensional structures of various functional biopolymers is extremely important for understanding biological phenomena in the ecology. In this study, we focused on the further improvement of the "lipid cubic method", which is a method for producing such a single crystal of a biopolymer. In this method, we believe that it is essential to deeply understand and elucidate the bicontinuous cubic liquid crystals that are the medium of crystallization, and newly design and synthesize the molecules that form the liquid-crystalline phases. Their self-organizing behaviors were analyzed by making full use of experiments and simulations.

Academic Significance and Societal Importance of the Research Achievements

本研究を通して、双連続キュービック液晶に関する重要な設計指針を得ることができた。
得られた成果は目的通り『脂質キュービック法』の改良に有効である。しかし、双連続キュービック液晶が形成するジャイロイド構造は三次元の連続性を有するナノ構造であることを考えると、サイズ選択分離膜・電解質膜など多様な応用展開において劇的なイノベーションを生む可能性を秘めており、この液晶の理解は、学術的に意義深い。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (38 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (4 results) Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 2 results) Presentation (20 results) (of which Int'l Joint Research: 6 results,  Invited: 8 results) Book (3 results) Remarks (1 results)

  • [Int'l Joint Research] Sheffield University(英国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Sheffield University(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Sheffield University(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Institute for Basic Science(韓国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Creation of Gyroid Nanostructured Polymer Films from Lyotropic Liquid Crystals Containing a Polymerizable Ionic Liquid as a Solvent2021

    • Author(s)
      Hiroaki Takeuchi and Takahiro Ichikawa
    • Journal Title

      Chemistry Letters

      Volume: -

    • NAID

      130008053371

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gyroid-Nanostructured All-Solid Polymer Films Combining High H+ Conductivity with Low H2 Permeability2021

    • Author(s)
      Tsubasa Kobayashi, Ya-xin Li, Yuichiro Hirota, Asako Maekawa, Norikazu Nishiyama, Xiang-bing Zeng, and Takahiro Ichikawa
    • Journal Title

      Macromolecular Rapid Communications

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design of Gyroid Nanostructured Soft Polymer Films Based on Self-organization of Liquid-crystalline Monomers2020

    • Author(s)
      一川 尚広
    • Journal Title

      ゼオライト

      Volume: 37 Issue: 3 Pages: 107-114

    • DOI

      10.20731/zeoraito.37.4.107

    • NAID

      40022398679

    • ISSN
      0918-7774
    • Year and Date
      2020-10-15
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gyroid nanostructured soft membranes formed by controlling the degree of crosslinking polymerization of bicontinuous cubic liquid-crystalline monomers2020

    • Author(s)
      Maekawa Asako、Kobayashi Tsubasa、Ichikawa Takahiro
    • Journal Title

      Polymer Journal

      Volume: 53 Issue: 3 Pages: 463-470

    • DOI

      10.1038/s41428-020-00436-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Double-Gyroid Nanostructure Formation by Aggregation-Induced Atropisomerization and Co-Assembly of Ionic Liquid-Crystalline Amphiphiles2020

    • Author(s)
      Nanami Uemura, Tsubasa Kobayashi, Shintaro Yoshida, Ya-xin Li, Karel Goossens, Xiangbing Zeng, Go Watanabe, and Takahiro Ichikawa
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 22 Pages: 8445-8450

    • DOI

      10.1002/anie.202000424

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glycine Substitution Effects on the Supramolecular Morphology and Rigidity of Cell‐Adhesive Amphiphilic Peptides2019

    • Author(s)
      Atsuya Ishida, Go Watanabe, Mio Oshikawa, Itsuki Ajioka, Takahiro Muraoka
    • Journal Title

      Chemistry - A European Journal

      Volume: 25 Issue: 59 Pages: 13523-13530

    • DOI

      10.1002/chem.201902083

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of lipidic bicontinuous cubic phases by the addition of a zwitterion with strong hydration ability and kosmotropicity2019

    • Author(s)
      Takeuchi Rika、Ichikawa Takahiro
    • Journal Title

      New Journal of Chemistry

      Volume: 43 Issue: 7 Pages: 3084-3090

    • DOI

      10.1039/c8nj05459b

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amphotropic liquid-crystalline behaviour of glycolipids in amino acid ionic liquids2019

    • Author(s)
      Shimizu Yukako、Takeuchi Hiroaki、Takeuchi Rika、Ichikawa Takahiro
    • Journal Title

      Liquid Crystals

      Volume: 1 Issue: 8 Pages: 1-9

    • DOI

      10.1080/02678292.2019.1591532

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A tailor-made design of lipidic bicontinuous cubic matrices using amino acid ionic liquids as self-assembly media2018

    • Author(s)
      Fujiwara Saki、Ohno Hiroyuki、Ichikawa Takahiro
    • Journal Title

      Molecular Systems Design & Engineering

      Volume: 3 Issue: 4 Pages: 668-676

    • DOI

      10.1039/c8me00015h

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of Dication-Type Amino Acid Ionic Liquids and Their Application to Self-Assembly Media of Amphiphiles2018

    • Author(s)
      Saki Fujiwara, Hiroyuki Ohno, Masafumi Yoshio, Takashi Kato, and Takahiro Ichikawa,
    • Journal Title

      Bull. Chem. Soc. Jpn.

      Volume: 91 Issue: 1 Pages: 1-5

    • DOI

      10.1246/bcsj.20170276

    • NAID

      130006309043

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] ジャイロイド極小界面を用いた三次元プロトン伝導パスの創成2021

    • Author(s)
      一川尚広
    • Organizer
      高分子同友会勉強会 “D 環境及びエネルギーに関する  最新の技術及び市場を勉強する会”
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ソフトな三次元プロトン伝導膜の創生に向けた重合性液晶分子の設計2020

    • Author(s)
      前川愛沙子、小林翼、一川尚広
    • Organizer
      2020年 高分子学会 (第69回高分子学会年次大会)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 両親媒性zwitterionを用いた親水性ジャイロイド界面の設計と湿度調整によるプロトン伝導パスの構築2020

    • Author(s)
      大城光、小林翼、一川尚広
    • Organizer
      2020年 高分子学会 (第69回高分子学会年次大会)
    • Related Report
      2020 Annual Research Report
  • [Presentation] ジャイロイド構造を有する柔軟な重合膜の作製に向けた 液晶性モノマーの分子改良2020

    • Author(s)
      竹山 実里、大城 光、前川 愛沙子、小林 翼、 一川 尚広
    • Organizer
      第10回CSJ化学フェスタ2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] イオン液体を用いたアトロプ異性体の設計とそのねじれを利用した三次元ジャイロイドナノ構造の構築2020

    • Author(s)
      小原壮貴、上村七海、一川尚広
    • Organizer
      イオン液体Workshop2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] ジャイロイド極小界面を活用したプロトン伝導膜の新設計2020

    • Author(s)
      一川尚広
    • Organizer
      第69回高分子討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ソフトなジャイロイド構造膜の設計と機能展開2020

    • Author(s)
      一川尚広
    • Organizer
      高分子講演会(東海)Ⅱ
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 分子シミュレーションで解き明かす有機材料の分子描像2020

    • Author(s)
      渡辺豪
    • Organizer
      第9回Qコロキウム オンライン開催
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 分子シミュレーションによる液晶の微視的描像解明2020

    • Author(s)
      渡辺豪
    • Organizer
      物性研究所スパコン共同利用・CCMS合同研究会「計算物質科学の新展開2020」
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Molecular design strategies for creating liquid crystals forming gyroid nanostructures and their advanced functions2019

    • Author(s)
      Takahiro Ichikawa, Hiroaki Takeuchi, Tsubasa Kobayashi, Nanami Uemura, Xiang-bing Zeng
    • Organizer
      ACS National Meeting & Expo
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 双連続キュービック液晶の分子設計手法の確立とその機能化に関する研究2019

    • Author(s)
      一川 尚広
    • Organizer
      2019年日本液晶学会討論会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Development of Functional Polymer Membranes Having Gyroid Nanostructures2019

    • Author(s)
      Takahiro Ichikawa
    • Organizer
      第68回高分子討論会 日韓ジョイントセッション/ Japan-Korea Joint Session
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 三次元アクアナノシートを形成するジャイロイド構造膜の創成2019

    • Author(s)
      一川 尚広・小林 翼・Zeng Xiang-bing
    • Organizer
      第68回高分子討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 液晶を用いたソフトなジャイロイド構造膜の設計2019

    • Author(s)
      一川尚広
    • Organizer
      第35 回ゼオライト研究発表会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Design of Functional Gyroid Surface through Self-organization of Liquid-crystalline Amphiphiles2019

    • Author(s)
      Takahiro Ichikawa
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Stabilization of lipidic cubic matrices by using strong hydration ability of zwitterions2018

    • Author(s)
      Rika Takeuchi, Takahiro Ichikawa
    • Organizer
      27th International Liquid Crystal Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design of gyroid-structured polymer films based on polymerizable bicontinuous cubic liquid crystals2018

    • Author(s)
      Takahiro Ichikawa
    • Organizer
      SPSI-MACRO-2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular Design Technology for Creating Ionic Bicontinuous Cubic Liquid Crystals2018

    • Author(s)
      Takahiro Ichikawa*, Rika Takeuchi, Yukako Shimizu, Hiroaki Takeuchi, Nanami Uemura, Ayaka Ono, Tsubasa Kobayashi
    • Organizer
      27th International Liquid Crystal Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脂質キュービックマトリックスの経時安定化に向けたイオン液体設計2017

    • Author(s)
      一川尚広・藤原沙希・竹内里佳・大野弘幸
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Construction of lipidic cubic matrix containing amino acid ionic liquids as solvents2017

    • Author(s)
      Saki Fujiwara, Hiroyuki Ohno, Takahiro Ichikawa
    • Organizer
      21st International Conference on Solid State Ionics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] 液晶2020

    • Author(s)
      一川尚広
    • Total Pages
      8
    • Publisher
      液晶学会
    • Related Report
      2019 Annual Research Report
  • [Book] 月刊化学2019

    • Author(s)
      小林 翼、一川 尚広
    • Total Pages
      5
    • Publisher
      化学同人
    • Related Report
      2019 Annual Research Report
  • [Book] クリーンエネルギー2019

    • Author(s)
      小林 翼、一川 尚広
    • Total Pages
      8
    • Publisher
      日本工業出版
    • Related Report
      2019 Annual Research Report
  • [Remarks] 一川研究室

    • URL

      http://web.tuat.ac.jp/~ichikawa/

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi