|Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
|Outline of Final Research Achievements
In this work, I determined the crystal structure of a novel photosensor protein CarH, which uses vitamin B12 (adenosylcobalamin) as a sensor module to elucidate the molecular mechanisms of photo-sensing by CarH. I also determined the crystal structure of HypX, which catalyzes CO biosynthesis for the construction of the sensor module in hydrogen sensor protein, NiFe-type hydrogenase. In the CO biosynthesis by HypX, formyl-CoA is produced as an reaction intermediate through the formyl group-transfer from N10-formyl-THF to coenzyme A.