|Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|Outline of Final Research Achievements
Messenger RNA (mRNA) carrying “genetic information” has 3’ poly(A) tail whose length regulation plays central roles in the post-transcriptional control of gene expression. Thus far, we have elucidated the mechanism of mRNA deadenylation (the initiation of mRNA decay), as well as negative regulation of gene expression targeting the deadenylation step. In this study, we have demonstrated that the positive regulation of gene expression by the post-transcriptional polyadenylation widely exists in somatic cells, and succeeded in verifying its general mechanism.