Development of new diagnostic method for refractory maliganant diseases

• Project/Area Number: 17H04110
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kyoto University
• Principal Investigator: Adachi Souichi 京都大学, 医学研究科, 教授 (10273450)
• Co-Investigator(Kenkyū-buntansha): 上久保 靖彦 京都大学, 医学研究科, 特定教授 (60548527)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
• Keywords: ゲノム / フローサイトメトリー法 / レーザーマイクロダイセクション / 癌遺伝子 / 予後因子 / ゲノム解析 / 腫瘍検査学 / 臨床血液学 / 遺伝子検査学 / 臨床病理学

Outline of Final Research Achievements

We carried out the following projects in order to establish new methodologies to detect new prognostic factors in childhood malignancies. (1) Establishment of new prognostic factors and new therapies for myeloid malignancies in children; we discovered new genetic mutations (CCND1, 2, 3) and new mechanism of cell death in t(8;21)AML and MLL-AML in children. (2) Establishment of new methodologies to detect and analyze malignant cells; we established the following three methodologies (minimal residual disease (MRD) by multi-color flow-cytometric analysis (FCM), XenoGraft Banking, lasermicrodisection). MRD detection in myeloid malignancies in down syndrome (JCCG AML clinical study; AML-D11) by FCM after initial chemotherapy are significant prognostic factor for predicting relapse (hazard ratio 10.58, p=0.02). We are also carrying out several projects for developing new drugs using refractory leukemic cells of children expanding by XenoGraft Banking system.

Academic Significance and Societal Importance of the Research Achievements

難治性腫瘍に対する新規診断法の開発は、新規治療法の開発に直結する重要な課題である。京都大学人間健康では、多くの臨床検査技師資格を有する教員、大学院生と共に、JCCG臨床試験の中央診断施設として、難治性白血病の新規治療法の開発を行ってきた。すでに、多次元フローサイトメトリー法の開発、XenoGraft Bankingシステム、レーザーマイクロダイセクション法の開発に成功しているが、現在、AIを用いた微小残存病変同定可能な機器の開発、ドットダイセクション法を用いた過去腫瘍検体からのゲノム解析を遂行中である。いずれも、難治性腫瘍患者のゲノム診断、新規治療法の開発に直結する重要な研究テーマである。

Research Products

• [Journal Article] Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. (2020)
  • Author(s): Aoki T, Takahashi H, Tanaka S, Shiba N, Hasegawa D, Iwamoto S, Terui K, Moritake H, Nakayama H, Shimada A, Koh K, Goto H, Kosaka Y, Saito A, Horibe K, Kinoshita A, Tawa A, Taga T, Adachi S, Tomizawa D.
  • Journal Title: Brit J Haematol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Continuous deep sedation at the end of life in children with cancer: experience at a single center in Japan. (2020)
  • Author(s): Maeda S, Kato I, Umeda K, Hiramatsu H, Takita J, Adachi S, Tsuneto S.
  • Journal Title: Pediatr Hemato Oncol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Retrospective analysis of children with high-risk acute myeloid leukemia who underwent allogeneic hematopoietic stem cell transplantation following complete remission with initial induction chemotherapy in the AML-05 clinical trial. (2019)
  • Author(s): Hyakuna N, Hashii Y, Ishida H, Umeda K, Takahashi Y, Nagasawa M, Yabe H, Nakazawa Y, Koh K, Goto H, Fujisaki H, Matsumoto K, Kakuda H, Yano M, Tawa A, Tomizawa D, Taga T, Adachi S, and Kato K.
  • Journal Title: Pediatr Blood Cancer Volume: 66 Issue: 10
  • DOI: 10.1002/pbc.27875
  • Peer Reviewed
• [Journal Article] Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia (2019)
  • Author(s): Shiba N, Yoshida K, Hara Y, Yamato G, Shiraishi Y, Matsuo H, Okuno Y, Chiba K, Tanaka H, Kaburagi T, Takeuchi M, Ohki K, Sanada M, Okubo J, Tomizawa D, Taki T, Shimada A, Sotomatsu M, Horibe K, Taga T, Adachi S, Tawa A, Miyano S, Ogawa S, Hayashi Y
  • Journal Title: Blood Adv Volume: 3 Issue: 20 Pages: 3157-3169
  • DOI: 10.1182/bloodadvances.2019000404
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Supportive care for hemostatic complications associated with pediatric leukemia: a national survey in Japan (2019)
  • Author(s): Shinya Osone, Keitaro Fukushima, Michihiro Yano, Mariko Kakazu, Hirozumi Sano, Yoko Kato, Yuichi Shinkoda, Kunihiro Shinoda, Naoko Mori, Souichi Adachi
  • Journal Title: International Journal of Hematology Volume: 110 Issue: 6 Pages: 743-750
  • DOI: 10.1007/s12185-019-02740-9
  • Peer Reviewed
• [Journal Article] Highly sensitive detection of GATA1 mutations in patients with myeloid leukemia associated with Down syndrome by combining Sanger and targeted next generation sequencing. (2019)
  • Author(s): Terui K, Toki T, Taga T, Iwamoto S, Miyamura T, Hasegawa D, Moritake H, Hama A, Nakashima K, Kanezaki R, Kudo K, Saito AM, Horibe K, Adachi S, Tomizawa D, Ito E.
  • Journal Title: Genes Chromosomes Cancer. Volume: - Issue: 3 Pages: 160-167
  • DOI: 10.1002/gcc.22816
  • Peer Reviewed
• [Journal Article] Characteristics and outcomes of children with acute myeloid leukemia and Down syndrome who are ineligible for clinical trials due to severe comorbidities. (2019)
  • Author(s): Nakashima K, Hasegawa D, Tomizawa D, Miyamura T, Hama A, Iwamoto S, Terui K, Adachi S, Taga T.
  • Journal Title: Pediatr Blood Cancer Volume: 66 Issue: 11
  • DOI: 10.1002/pbc.27942
  • Peer Reviewed
• [Journal Article] Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. (2019)
  • Author(s): Miyamura T, Moritake H, Nakayama H, Tanaka S, Tomizawa D, Shiba N, Saito AM, Tawa A, Shimada A, Iwamoto S, Hayashi Y, Koike T, Horibe K, Manabe A, Mizutani S, Taga T, Adachi S.
  • Journal Title: Br J Haematol. Volume: 19 Issue: 2 Pages: 284-288
  • DOI: 10.1111/bjh.15799
  • Peer Reviewed
• [Journal Article] Oocyte cryopreservation for a female cancer patient after reaching adulthood (2019)
  • Author(s): Ogata Hideto、Umeda Katsutsugu、Tani Hirohiko、Horie Akihito、Adachi Souchi
  • Journal Title: Pediatrics International Volume: 61 Issue: 2 Pages: 207-208
  • DOI: 10.1111/ped.13752
  • Peer Reviewed
• [Journal Article] Impact of low-dose irradiation and in vivo T-cell depletion on hematopoietic stem cell transplantation for non-malignant diseases using fludarabine-based reduced-intensity conditioning (2019)
  • Author(s): Katsutsugu K、、Yabe H、Kato K、Adachi S、Atsuta Y、Morio T et al.
  • Journal Title: Bone Marrow Transplantation Volume: 印刷中 Issue: 8 Pages: 1227-1236
  • DOI: 10.1038/s41409-018-0418-8
  • Peer Reviewed / Open Access
• [Journal Article] Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients. (2019)
  • Author(s): Mori M, Hira A, Yoshida K, Muramatsu H, Okuno Y, Shiraishi Y, Anmae M, Yasuda J, Tadaka S, Kinoshita K, Osumi T, Noguchi Y, Adachi S, Kobayashi R, Kawabata H, Imai K, Morio T, Tamura K, Takaori-Kondo A, Yamamoto M, Miyano S, Kojima S, Ito E, Ogawa S, Matsuo K, Yabe H, Yabe M, Takata M.
  • Journal Title: Haematologica. Volume: - Issue: 10 Pages: 1962-1973
  • DOI: 10.3324/haematol.2018.207241
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prophylaxis and treatment with mycophenolate mofetil in children with graft-versus-host disease undergoing allogeneic hematopoietic stem cell transplantation: a nationwide survey in Japan (2019)
  • Author(s): Kawashima Nozomu、Iida Minako、Suzuki Ritsuro、Fukuda Takahiro、Atsuta Yoshiko、Hashii Yoshiko、Inoue Masami、Kobayashi Masao、Yabe Hiromasa、Okada Keiko、Adachi Souichi、Yuza Yuki、Kawa Keisei、Kato Koji
  • Journal Title: International Journal of Hematology Volume: 109 Issue: 4 Pages: 491-498
  • DOI: 10.1007/s12185-019-02601-5
  • NAID: 120006652420
  • Peer Reviewed
• [Journal Article] Progressive Restrictive Ventilatory Impairment in Idiopathic Diffuse Pulmonary Ossification (2018)
  • Author(s): Matsuo H, Handa T, Tsuchiya M, Kubo T, Yoshizawa A, Nakayama Y, Shiga S, Hitomi T, Adachi S, Date H, Hirai T, Ichiyama S.
  • Journal Title: Internal Medicine Volume: 57 Issue: 11 Pages: 1631-1636
  • DOI: 10.2169/internalmedicine.9433-17
  • NAID: 130007382812
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-06-01
  • Peer Reviewed / Open Access
• [Journal Article] RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells. (2018)
  • Author(s): Mitsuda Y, Morita K, Kashiwazaki G, Taniguchi J, Bando T, Obara M, Hirata M, Kataoka TR, Muto M, Kaneda Y, Nakahata T, Liu PP, Adachi S, Sugiyama H, Kamikubo Y.
  • Journal Title: Sci. Rep. Volume: 8 Issue: 1 Pages: 6423-6423
  • DOI: 10.1038/s41598-018-24969-w
  • NAID: 120006510275
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RUNX1 mutations in pediatric acute myeloid leukemia are associated with distinct genetic features and an inferior prognosis. (2018)
  • Author(s): 1.Yamato G, Shiba N, Yoshida K, Hara Y, Shiraishi Y, Ohki K, Okubo J, Park MJ, Sotomatsu M, Arakawa H, Kiyokawa N, Tomizawa D, Adachi S, Taga T, Horibe K, Miyano S, Ogawa S, Hayashi Y.
  • Journal Title: Blood Volume: Epub Issue: 20 Pages: 2266-2270
  • DOI: 10.1182/blood-2017-11-814442
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Risk-stratified therapy for children with FLT3-ITD-positive acute myeloid leukemia: results from the JPLSG AML-05 study. (2018)
  • Author(s): Shimada A, Iijima-Yamashita Y, Tawa A, Tomizawa D, Yamada M, Norio S, Watanabe T, Taga T, Iwamoto S, Terui K, Moritake H, Kinoshita A, Takahashi H, Nakayama H, Koh K, Goto H, Kosaka Y, Saito AM, Kiyokawa N, Horibe K, Hara Y, Oki K, Hayashi Y, Tanaka S, Adachi S.
  • Journal Title: Int J Hematol. Volume: 107(5) Issue: 5 Pages: 586-595
  • DOI: 10.1007/s12185-017-2395-x
  • Peer Reviewed
• [Journal Article] High incidence of BK virus-associated hemorrhagic cystitis in children after second or third allogeneic hematopoietic stem cell transplantation. (2018)
  • Author(s): Umeda K, Kato I, Kawaguchi K, Tasaka K, Kamitori T, Ogata H, Mikami T, Hiramatsu H, Saito R, Ogawa O, Takahashi T, Adachi S.
  • Journal Title: Pediatr Transplant Volume: 22 Issue: 4
  • DOI: 10.1111/petr.13183
  • Peer Reviewed
• [Journal Article] Allogeneic hematopoietic stem cell transplantation for children and adolescents with high-risk cytogenetic AML: distinctly poor outcomes of FUS-ERG-positive cases (2018)
  • Author(s): Tomizawa Daisuke、Yoshida Masanori、Kondo Tadakazu、Miyamura Takako、Taga Takashi、Adachi Souichi、Koh Katsuyoshi、Noguchi Maiko、Kakuda Harumi、Watanabe Kenichiro、Cho Yuko、Fukuda Takahiro、Kato Motohiro、Shiba Norio、Goto Hiroaki、Okada Keiko、Inoue Masami、Hashii Yoshiko、Atsuta Yoshiko、Ishida Hiroyuki
  • Journal Title: Bone Marrow Transplantation Volume: 54 Issue: 3 Pages: 393-401
  • DOI: 10.1038/s41409-018-0273-7
  • Peer Reviewed
• [Journal Article] Evaluation of high-dose cytarabine in induction therapy for children with de novo acute myeloid leukemia: a study protocol of the Japan Children's Cancer Group Multi-Center Seamless Phase II-III Randomized Trial (2018)
  • Author(s): 3.Tomizawa D, Tanaka S, Hasegawa D, Iwamoto S, Hiramatsu H, Kiyokawa N, Miyachi H, Horibe K, Saito AM, Taga T, Adachi S.
  • Journal Title: Jpn J Clin Oncol. Volume: 48 Issue: 6 Pages: 587-593
  • DOI: 10.1093/jjco/hyy061
  • Peer Reviewed
• [Journal Article] Influence of post-transplant mucosal-associated invariant T cell recovery on the development of acute graft-versus-host disease in allogeneic bone marrow transplantation (2018)
  • Author(s): Kawaguchi Koji、Umeda Katsutsugu、Hiejima Eitaro、Iwai Atsushi、Mikami Masamitsu、Nodomi Seishiro、Saida Satoshi、Kato Itaru、Hiramatsu Hidefumi、Yasumi Takahiro、Nishikomori Ryuta、Kondo Tadakazu、Takaori-Kondo Akifumi、Heike Toshio、Adachi Souichi
  • Journal Title: International Journal of Hematology Volume: 印刷中 Issue: 1 Pages: 66-75
  • DOI: 10.1007/s12185-018-2442-2
  • Peer Reviewed
• [Journal Article] Nationwide survey of therapy-related leukemia in childhood in Japan (2018)
  • Author(s): Imamura T, Taga T, Takagi M, Kawasaki H, Koh K, Taki T, Adachi S, Manabe A, Ishida Y; Leukemia/Lymphoma Committee; Japanese Society of Pediatric Hematology Oncology (JSPHO)
  • Journal Title: Int J Hematol Volume: 108 Issue: 1 Pages: 91-97
  • DOI: 10.1007/s12185-018-2439-x
  • Peer Reviewed
• [Journal Article] High-dose chemotherapy with autologous stem cell transplantation spares re-irradiation for recurrent intracranial germinoma (2018)
  • Author(s): Kubota Hirohito、Umeda Katsutsugu、Kagehiro Kouzuki、Tanaka Kuniaki、Daifu Tomoo、Hamabata Takayuki、Nodomi Seishiro、Kato Itaru、Hiramatsu Hidefumi、Arakawa Yoshiki、Mizowaki Takashi、Adachi Souichi
  • Journal Title: Pediatric Blood & Cancer Volume: 65 Issue: 8
  • DOI: 10.1002/pbc.27104
  • Peer Reviewed
• [Journal Article] Secondary bone/soft tissue sarcoma in childhood cancer survivors: a nationwide hospital-based case-series study in Japan (2018)
  • Author(s): Ishida Yasushi、Maeda Miho、Adachi Souichi、Rikiishi Takeshi、Sato Maho、Kawaguchi Hiroshi、Manabe Atsushi、Tokuyama Mika、Hori Hiroki、Okamura Jun、Ogawa Atsushi、Goto Hiroaki、Kobayashi Ryoji、Yoshinaga Shinji、Fujimoto Junichiro、Kuroda Tatsuo
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 48 Issue: 9 Pages: 806-814
  • DOI: 10.1093/jjco/hyy102
  • Peer Reviewed
• [Journal Article] Chronic myeloid leukemia following treatment for bilateral retinoblastoma (2018)
  • Author(s): Kamitori Tatsuya、Umeda Katsutsugu、Tasaka Keiji、Ogata Hideto、Mikami Takashi、Kato Itaru、Hiramatsu Hidefumi、Kondo Tadakazu、Adachi Souichi
  • Journal Title: Pediatric Blood & Cancer Volume: 65 Issue: 9
  • DOI: 10.1002/pbc.27107
  • NAID: 120006882426
  • Peer Reviewed
• [Journal Article] Clinical characteristics of pediatric patients with myeloid sarcoma without bone marrow involvement in Japan (2018)
  • Author(s): Taga T, Imamura T, Nakashima K, Maeda N, Watanabe A, Miyajima Y, Sakaguchi S, Sano H, Hasegawa D, Kawasaki H, Adachi S, Takagi M, Koh K, Manabe A, Taki T, Ishida Y
  • Journal Title: Int J Hematol Volume: 108 Issue: 4 Pages: 438-442
  • DOI: 10.1007/s12185-018-2492-5
  • Peer Reviewed
• [Journal Article] Sudden spinal hemorrhage in a pediatric case with total body irradiation-induced cavernous hemangioma (2018)
  • Author(s): Mikami T, Kato I, Nozaki F, Umeda K, Kamitori T, Tasaka K, Ogata H, Hiramatsu H, Arakawa Y, Adachi S
  • Journal Title: Pediatr Blood Cancer. Volume: 65 Issue: 10
  • DOI: 10.1002/pbc.27250
  • Peer Reviewed
• [Journal Article] Cytomegalovirus infection in pediatric patients with hepatoblastoma after liver transplantation. (2018)
  • Author(s): Nodomi S, Umeda K, Kato I, Saida S, Hiramatsu H, Ogawa E, Yoshizawa A, Okamoto S, Okajima H, Uemoto S, Adachi S.
  • Journal Title: Pediatr Transplant. Volume: 22 Issue: 7
  • DOI: 10.1111/petr.13273
  • Peer Reviewed
• [Journal Article] Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia (2018)
  • Author(s): Matsuo Hidemasa、Itonaga Hidehiro、et al.
  • Journal Title: Blood Advances Volume: 2 Issue: 21 Pages: 2879-2889
  • DOI: 10.1182/bloodadvances.2018019398
  • NAID: 120006534600
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sudden Intracranial Hemorrhage in a Patient With Atypical Chronic Myeloid Leukemia in Chronic Phase (2018)
  • Author(s): Kouzuki Kagehiro、Umeda Katsutsugu、Saida Satoshi、Kato Itaru、Hiramatsu Hidefumi、Funaki Takeshi、Kanda Kenji、Muramatsu Hideki、Yoshida Kenichi、Ogawa Seishi、Adachi Souichi
  • Journal Title: Journal of Pediatric Hematology/Oncology Volume: 40 Issue: 8 Pages: e553-e556
  • DOI: 10.1097/mph.0000000000001061
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Secondary cancer after a childhood cancer diagnosis: viewpoints considering primary cancer. (2018)
  • Author(s): Ishida Y, Maeda M, Adachi S, Inada H, Kawaguchi H, Hori H, Ogawa A, Kudo K, Kiyotani C, Shichino H, Rikiishi T, Kobayashi R, Sato M, Okamura J, Goto H, Manabe A, Yoshinaga S, Qiu D, Fujimoto J, Kuroda T.
  • Journal Title: Int J Clin Oncol Volume: 23 Issue: 6 Pages: 1178-1188
  • DOI: 10.1007/s10147-018-1303-6
  • Peer Reviewed
• [Journal Article] Sequential use of second-generation tyrosine kinase inhibitors following imatinib therapy in pediatric chronic myeloid leukemia: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (2018)
  • Author(s): Kurosawa Hidemitsu、Tanizawa Akihiko、Muramatsu Hideki、Tono Chikako、Watanabe Akihiro、Shima Haruko、Ito Masaki、Yuza Yuki、Hamamoto Kazuko、Hotta Noriko、Okada Masahiko、Saito Akiko Moriya、Manabe Atsushi、Mizutani Shuki、Adachi Souichi、Horibe Keizo、Ishii Eiichi、Shimada Hiroyuki
  • Journal Title: Pediatric Blood & Cancer Volume: 65 Issue: 12
  • DOI: 10.1002/pbc.27368
  • Peer Reviewed / Open Access
• [Journal Article] Paraneoplastic hypereosinophilic syndrome associated with IL3-IgH positive acute lymphoblastic leukemia (2018)
  • Author(s): Kobayashi Kenichiro、Mizuta Shumpei、Yamane Noriko、Ueno Hiroo、Yoshida Kenichi、Kato Itaru、Umeda Katsutsugu、Hiramatsu Hidefumi、Suehiro Minoru、Maihara Toshiro、Usami Ikuya、Shiraishi Yuichi、Chiba Kenichi、Miyano Satoru、Adachi Souichi、Ogawa Seishi、Kiyokawa Nobutaka、Heike Toshio
  • Journal Title: Pediatric Blood & Cancer Volume: 66 Issue: 1
  • DOI: 10.1002/pbc.27449
  • Peer Reviewed
• [Journal Article] RUNX transcription factors potentially control E-selectin expression in the bone marrow vascular niche in mice. (2018)
  • Author(s): Morita K, Tokushige C, Maeda S, Kiyose H, Noura M, Iwai A, Yamada M, Kashiwazaki G, Taniguchi J, Bando T, Hirata M, Kataoka TR, Nakahata T, Adachi S, Sugiyama H, Kamikubo Y.
  • Journal Title: Blood Adv Volume: 2 Issue: 5 Pages: 509-515
  • DOI: 10.1182/bloodadvances.2017009324
  • Peer Reviewed / Open Access
• [Journal Article] Monitoring of fusion gene transcripts to predict relapse in pediatric acute myeloid leukemia. (2018)
  • Author(s): Matsuo H, Iijima-Yamashita Y, Yamada M, Deguchi T, Kiyokawa N, Shimada A, Tawa A, Tomizawa D, Taga T, Kinoshita A, Adachi S, Horibe K.
  • Journal Title: Pediatr Int. Volume: 60(1) Issue: 1 Pages: 41-46
  • DOI: 10.1111/ped.13440
  • Peer Reviewed
• [Journal Article] Multiplex fusion gene testing in pediatric acute myeloid leukemia. (2018)
  • Author(s): Iijima-Yamashita Y, Matsuo H, Yamada M, Deguchi T, Kiyokawa N, Shimada A, Tawa A, Takahashi H, Tomizawa D, Taga T, Kinoshita A, Adachi S, Horibe K.
  • Journal Title: Pediatr Int. Volume: 60(1) Issue: 1 Pages: 47-51
  • DOI: 10.1111/ped.13451
  • Peer Reviewed
• [Journal Article] Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells. (2017)
  • Author(s): Morita K, Noura M, Tokushige C, Maeda S, Kiyose H, Kashiwazaki G, Taniguchi J, Bando T, Yoshida K, Ozaki T, Matsuo H, Ogawa S, Liu PP, Nakahata T, Sugiyama H, Adachi S, Kamikubo Y.
  • Journal Title: Sci Rep. Volume: 7(1) Issue: 1 Pages: 16604-16604
  • DOI: 10.1038/s41598-017-16799-z
  • NAID: 120006368172
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia (2017)
  • Author(s): Kuwatsuka Y、Asou N、Ohtake S、Miyawaki S、Miyazaki Y、Sakura T、Ozawa Y、Usui N、Kanamori H、Ito Y、Imai K、Suehiro Y、Kobayashi S、Kitamura K、Sakaida E、Ogawa S、Naoe T、Hayashi Y、Horibe K、Manabe A、Mizutani S、Adachi S、Kiyoi H et al.
  • Journal Title: International Journal of Hematology Volume: 107 Issue: 2 Pages: 201-210
  • DOI: 10.1007/s12185-017-2340-z
  • NAID: 120006473552
  • Peer Reviewed
• [Presentation] Post-induction minimal residual disease measured by flow cytometry and deep sequencing of mutant GATA1 are both significant prognostic factors for children with myeloid leukemia and Down syndrome: a nationwide prospective study of the Japanese Pediatric Leukemia/Lymphoma Study Group. (2019)
  • Author(s): Taga T, Tanaka S, Terui K, Iwamoto S, Hiramatsu H, Miyamura T, Hashii Y, Hasegawa D, Moritake H, Nakayama H, Takahashi H, Shimada A, Taki T, Toki T, Ito E, Koh K, Hasegawa D, Hama A, Saito AM, Adachi S, Tomizawa D.
  • Organizer: 61st Annual Meeting of the American Society of Hematology,
  • Int'l Joint Research
• [Presentation] Clinical Features of Children with Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis in Japan: Retrospective Nationwide Survey. (2019)
  • Author(s): Ishida H, Sarashina T, Matsumura R, Umeda K, Mitsui T, Fujita N, Tomizawa D, Urayama K, Ishida Y, Taga T, Takagi M, Adachi S, Manabe A, Imamura T, Koh K, Shimada A.
  • Organizer: 61st Annual Meeting of the American Society of Hematology,
  • Int'l Joint Research
• [Presentation] Coexistence and prognostic significance of EVI1 expression and driver mutations in KMT2A-rearranged acute myeloid leukemia. (2019)
  • Author(s): Matsuo H, Yoshida K, Nakatani K, Kamikubo Y, Tomizawa D, Taga T, Kiyokawa N, Ogawa S, Meggendorfer M, Haferlach C, Adachi S.
  • Organizer: 61st Annual Meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] Significant features of DNA methylation at bivalent promotor and repressed polycomb regions in pediatric AML-the JCCG study, JPLSG AML05 (2019)
  • Author(s): Yamato G, Kawai T, Shiba N, Hara Y, Ohki K, Kaburagi T, Yoshida K, Shiraishi Y, Miyano S, Kiyokawa N, Tomizawa D, Shimada A, Sotomatsu M, Arakawa H, Adachi S, Taga T, Horibe K, Ogawa S, Hata K, Hayashi Y.
  • Organizer: 61st Annual Meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] Clinical Features of Pediatric Acute Myeloid Leukemia with TP53 and CDKN2A/2B Copy Number Alterations. (2019)
  • Author(s): Hara Y, Taki T, Yamato G, Yoshida K, Shiozawa Y, Shiba N, Kaburagi T, Shiraishi Y, Ohki K, Kawamura M, Sotomatsu M, Arakawa H, Matsuo H, Shimada A, Toki T, Kiyokawa N, Tomizawa D, Taga T, Ito E, Horibe K, Miyano S, Ogawa S, Adachi S, Hayashi Y.
  • Organizer: 61st Annual Meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] Recurrent gene mutations in pediatric AML patients by targeted sequencing ―the JCCG study, JPLSG AML-05― (2019)
  • Author(s): Kaburagi T, Yamato G, Shiba N, Yoshida K, Hara Y, Shiraishi Y, Ohki K, Sotomatsu M, Arakawa H, Matsuo H, Shimada A, Taki T, Kiyokawa N, Tomizawa D, Horibe K, Miyano S, Taga T, Adachi S, Ogawa S, Hayashi Y.
  • Organizer: 61st Annual Meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] The detection of minor clones with somatic KIT D816V mutations by droplet digital PCR in pediatric de novo AML. (2019)
  • Author(s): Sasaki K, Uchiyama Y, Ikeda J, Yoshitomi M, Shimosato-Wada Y, Tokumasu M, Matsuo H, Yoshida K, Ohki K, Yamato G, Hara Y, Kinoshita A, Tomizawa D, Taga T, Adachi S, Tawa A, Horibe K, Matsumoto N, Ito S, Hayashi Y, Shiba N.
  • Organizer: 61st Annual Meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] Negative CD19 Expression Is Associated with Inferior Relapse-Free Survival in RUNX1-RUNX1T1-Positive Acute Myeloid Leukemia; The Japanese Pediatric Leukemia/Lymphoma Study Group Experience from the AML-05 Study. (2018)
  • Author(s): Imamura T, Sakamoto K, Shiba N, Deguchi T, Kiyokawa N, Hashii Y, Saito AM, Tomizawa D, Taga T and Adachi S.
  • Organizer: 第60回アメリカ血液学会
  • Int'l Joint Research
• [Presentation] Clinical Feature and Genetic Alterations in Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia and Myeloid/NK Cell Acute Leukemia、 (2018)
  • Author(s): Nishimura A, Yokoyama K, Adachi S, Koh K, Manabe A, Taki T, Ishida Y, Tojo A, Takagi M. et al.
  • Organizer: 第60回アメリカ血液学会
  • Int'l Joint Research
• [Presentation] Recurrent Genomic Aberrations of D-Type Cyclins Are Therapeutic Targets of CDK4/6 Inhibitors in t(8;21) and MLL-Rearranged Acute Myeloid Leukemia、 (2018)
  • Author(s): Matsuo H, Yoshida K, Kamikubo Y, Ogawa S, Adachi S et al.
  • Organizer: 第60回アメリカ血液学会
  • Int'l Joint Research
• [Presentation] Comprehensive Analysis of 343 Genes Using Targeted Sequencing Panel By Next-Generation Sequencer in 77 Pediatric AML Patients with Normal and Complex Karyotypes: JCCG Study, JPLSG AML-05. (2018)
  • Author(s): Kaburagi T, Yamato G, Shiba N, Yoshida K, Hara Y, Shiraishi Y, Ohki K, Sotomatsu M, Arakawa H, Matsuo H, Shimada A, Kiyokawa N, Tomizawa D, Taga T, Horibe K, Miyano S, Ogawa S, Adachi S, Hayashi Y,
  • Organizer: 第60回アメリカ血液学会
  • Int'l Joint Research
• [Presentation] Effect of Age on the Prognosis of Molecular Abnormalities in Pediatric Acute Myeloid Leukemia、 (2018)
  • Author(s): Hara Y, Shiba N, Yamato G, Ohki K, Sotomatsu M, Tabuchi K, Tomizawa D, Taki T, Kinoshita A, Kiyokawa N, Arakawa H, Shibuya M, Taga T, Tawa A, Horibe K, Adachi S, Hayashi Y.
  • Organizer: 第60回アメリカ血液学会
  • Int'l Joint Research
• [Presentation] Hematopoietic Cell Transplantation for Children with Acute Megakaryoblastic Leukemia without Down Syndrome、 (2018)
  • Author(s): Hama A, Taga T, Tomizawa D, Muramatsu H, Hasegawa D, Adachi S, Yoshida N, Noguchi M, Inoue M, Okada K, Koh K, Atsuta Y, Ishida H.
  • Organizer: 第60回アメリカ血液学会
  • Int'l Joint Research
• [Presentation] Outcome of allogeneic hematopoietic stem cell transplantation for children and adolescents with acute myeloid leukemia and high-risk cytogenetics. (2018)
  • Author(s): Tomizawa D, Yoshida M, Kondo T, Miyamura T, Taga T, Adachi S, Koh K, Noguchi M, Kakuda H, Shiba N, Watanabe K, Inoue M, Hashii Y, Atsuta Y, Ishida H:
  • Organizer: 第50回国際小児がん学会
  • Int'l Joint Research
• [Presentation] Age and NRAS mutation status are possible prognostic markers in pediatric acute myeloid leukemia with CBFB-MYH11 fusion gene. (2018)
  • Author(s): Hara Y, Shiba N, Ohki K, Yamato G, Sotomatsu M, Tomizawa D, Taki T, Kinoshita A, Kiyokawa N, Arakawa H, Tawa A, Horibe K, Taga T, Adachi S, Hayashi Y
  • Organizer: 第50回国際小児がん学会
  • Int'l Joint Research
• [Presentation] Clinical significance of mutations of RAS pathway related genes including PTPN11, RAS, and CBL genes in pediatric AML -the JCCG study, JPLSG AML-05-. (2018)
  • Author(s): Kaburagi T, Yamato G, Shiba N, Hara Y, Ohki K, Sotomatsu M, Arakawa H, Kiyokawa N, Tomizawa D, Adachi S, Taga T, Horibe K, Hayashi Y.
  • Organizer: 第50回国際小児がん学会
  • Int'l Joint Research
• [Presentation] Prognostic impact of neutropenia period in patients with acute myeloid leukemia (AML) enrolled in the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 study. (2018)
  • Author(s): Aoki T, Takahashi H, Tanaka S, Shiba N, Hasegawa D, Iwamoto S, Terui K, Moritake H, Nakayama H, Shimada A, Koh K, Goto H, Kosaka Y, Saito AM, Horibe K, Kinoshita A, Tomizawa D, Tawa A, Taga T, Adachi S:
  • Organizer: 第50回国際小児がん学会
  • Int'l Joint Research
• [Presentation] Prognosis of pediatric AML patients with FLT3-ITD is predicted by DNA methylation pattern -the JCCG study JPLAG AML-05-. (2018)
  • Author(s): Yamato G, Kawai T, Shiba N, Ohki K, Hara Y, Kiyokawa N, Tomizawa D, Shimada A, Sotomatsu M, Arakawa H, Adachi S, Taga T, Horibe K, Hata K, Hayashi Y:
  • Organizer: 第50回国際小児がん学会
  • Int'l Joint Research
• [Presentation] Secondary cancer after a childhood cancer diagnosis: Viewpoints considering primary cancer. (2018)
  • Author(s): Ishida Y, Maeda M, Adachi S et al.
  • Organizer: 第50回国際小児がん学会
  • Int'l Joint Research
• [Presentation] Characteristics and outcome of children with acute myeloid leukemia and Down syndrome ineligible for clinical studies, (2018)
  • Author(s): Nakashima K, Hasegawa D, Miyamura T, Hama A, Iwamoto S, Terui K, Tomizawa D, Adachi S, Taga T
  • Organizer: 第11回小児白血病リンパ腫シンポジウム
  • Int'l Joint Research
• [Presentation] Novel Anti-Leukemia Therapeutic Strategy Through CROX(Cluster Regulation of RUNX Family) (2018)
  • Author(s): Furuichi K, Noguchi Y, Suzuki Y, Iwai S, Shimada S, Iwai A, Sugiyama H, Adachi S, Kamikubo Y:
  • Organizer: 第9回日本血液学会国際シンポジウム
  • Int'l Joint Research
• [Presentation] Highly Efficient Elimination of p210-,p190-BCR=ABL Protein Through CROX Strategy. (2018)
  • Author(s): Shimada S, Noguchi Y, Suzuki Y, Iwai S, Furuichi K, Sugiyama H, Kamikubo Y, Adachi S:
  • Organizer: 第9回日本血液学会国際シンポジウム
  • Int'l Joint Research
• [Presentation] Vascular Niche Regulation Through RUNX1 Attenuating E-Selectin. (2018)
  • Author(s): Noguchi Y, Suzuki Y, Furuichi K, Iwai S, Shimada S, Sugiyama H, Adachi S, Kamikubo Y
  • Organizer: 第9回日本血液学会国際シンポジウム
  • Int'l Joint Research
• [Presentation] Hematopoietic cell transplantation for children with acute megakaryoblastic leukemia. (2018)
  • Author(s): Hama A, Taga T, Tomizawa D, Muramatsu H, Hasegawa D, Adachi S, Kato K, Noguchi M, Inoue M, Okada K, Koh K, Atsuta Y, Ishida H:
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] The detection of minor clones with somatic KIT D816V mutations in pediatric de novo AML. (2018)
  • Author(s): Sasaki K, Shiba N, Uchiyama Y, Ikeda J, Yoshitomi M, Shimosato Y, Tokumasu M, Matsuo H, Yoshida K, Ohki K, Yamato G, Hara Y, Kinoshita A, Tomizawa D, Taga T, Adachi S, Tawa A, Horibe K, Matsumoto N, Ito S, Hayashi Y
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Identification of recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia. (2018)
  • Author(s): Matsuo H, Yoshida K, Kamikubo Y, Ogawa S, Adachi S et al.
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Clinical significance and prognostic analyses of PTPN11, RAS, and CBL mutations in pediatric AML. (2018)
  • Author(s): Kaburagi T, Yamato G, Shiba N, Hara Y, Ohki K, Sotomatsu M, Arakawa H, Kiyokawa N, Tomizawa D, Adachi S, Taga T, Horibe K, Hayashi Y
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Correlation between obesity and outcome in patients with AML enrolled in the JPLSG AML-05 study. (2018)
  • Author(s): Sano H, Fukushima K, Yano M, Osone S, Kato Y, Shinkoda Y, Mori N, Ishida Y, Saito Y, Sawada A, Toyoda H, Hasegawa D, Miyamura T, Iwamoto S, Takahashi H, Terui K, Koh K, Goto H, Kosaka Y, Saito AM, Horibe K, Kinoshita A, Tomizawa D, Tawa A, Taga T, Adachi S,
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] CROX(Cluster regulation of RUNX)induces apoptoic cell death through regulatin g Gene X in APL cells. (2018)
  • Author(s): Furuichi K, Iwai A, Mikami M, Takasaki S, Obara M, Hattori E, Noguchi Y, Sugiyama H, Adachi S, Kamikubo Y:
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Vital roke of RUNX1 both in the regulation of BCR-ABL expression and in the maintenanceof CML cells. (2018)
  • Author(s): Shimada S, Maeda S, Noguch Y, Iwai S, Suzuki Y, Sugiyama H, Kamikubo Y, Adachi S
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Secondary bone/soft tissue sarcoma in childhood cancer survivors: A nationwide hospital based case-series study in Japan (2018)
  • Author(s): Ishida Y, Maeda M, Adachi S et al.
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] Suppression of malignant rhabdoid tumors through novel drug based on Gene Switch Technology. (2018)
  • Author(s): Masamitsu Mikami, Tomoo Daifu, Takuya Kanatani, Kana Furuichi, Saho Takasaki, Atsushi Iwai, Yuki Noguchi, Yuta Suzuki, Etsuko Httori, Yasuzumi Matsui, Hiroshi Sugiyama, Yasuhiko Kamikubo, Souichi Adachi
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Inhibition of BCR-ABL expression through CROX(Cluster regulation of RUNX). (2018)
  • Author(s): Sae Shimada, Yuki Noguchi, Shiina Iwai, Yuta Suzuki, Hiroshi Sugiyama, Yasuhiko Kamikubo, Souichi Adachi
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Cluster regulation of RUNX induces apoptotic cell death through regulating gene X in acute promyelocytic leukemia (APL). (2018)
  • Author(s): Kana Furuichi, Atsushi Iwai, Masamitsu Mikami, Saho Takasaki, Moeka Obara, Etsuko Hattori, Yuki Noguchi, Toshiya Tatsuta, Yuta Suzuki, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo:
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Biological significance of nascent BCR-ABL revealed by modeling translocation (9;22)using CRISPR/Cas9system. (2018)
  • Author(s): Tsukimi Shoji, Asumi Yokota, Atsushi Sato, Naoka Kamio, Takahiro Kashiwagi, Yusuke Torikoshi, Yasuo Miura, Souichi Adachi, Taira Maekawa, Hideyo Hirai:
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Combinatorial Histone Acetyltransferases(HATs) inhibition as a potential therapeutic approach for pancreatic cancer. (2018)
  • Author(s): Shino Kobyaashi, Yuki Noguchi, Erika Okinak, Natsuki Wariishi, Shiina Iwai, Sae Shimada, Yuta Suzuki, Mai Oyama, Souichi Adachi, Yasuhiko Kamikubo
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Genetic regulation of RUNX2-cancer stem cell marker X axis in CRPC-NE cells. (2018)
  • Author(s): Yuki Noguchi, Natsuki Wariishi, Shiina Iwai, Sae Shimada, Yuta Suzuki, Mai Ohyama, Yasuzumi Matsui, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Regulation of HAT induces apoptotic cell death through regulating hypoxia mechanism in RCC and osteosarcoma cells. (2018)
  • Author(s): Saho Takasaki, Masamitsu Mikami, Kana Furuichi, Atsushi Iwai, Moeka Obara, Yuki Noguchi, Takuya Kanatani, Yuta Suzuki, Yasuhiko Kamikubo, Souichi Adachi.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Negative CD19 expression is associated with inferior relapse free survival in RUNX1-RUNX1T1 positive AML; JPLSG experience from the AML-05 study. (2018)
  • Author(s): Sakamoto K, Shiba N, Deguchi T, Kiyokawa N, Hashii Y, Saito A, Tomizawa D, Taga T, Adachi S, Imamura T
  • Organizer: 第60回日本小児血液・がん学会学術集会
• [Presentation] 小児がん経験者の２次性成人型がんの解析：本邦における後方視的検討 (2018)
  • Author(s): Maho Sato, Shinji Yoshinaga, Miho Maeda, Souichi Adachi, Hiroko Inada, Hiroki Hori, Atsushi Ogawa, Ryoji Kobayashi, Hiroaki Goto, Atsushi Manabe, Kika Tokuyama, Junichiro Fujimoto, Tatsuo Kuroda, Yasushi Ishida
  • Organizer: 第60回日本小児血液・がん学会学術集会
• [Presentation] 遺伝子スイッチ法を用いた、悪性ラブドイド腫瘍に対する新規治療戦略の構築 (2018)
  • Author(s): Masamitsu Mikami, Tomoo Daifu, Takuya Kanatani, Kana Furuichi, Saho Takasaki, Atsushi Iwai, Katsutsugu Umeda, Hiroshi Sugiyama, Yasuhiko Kamikubo, Souichi Adachi
  • Organizer: 第60回日本小児血液・がん学会学術集会
• [Presentation] 神経芽細胞におけるRUNX1-TRIM24/BCL11A-p53 axisの重要性に関する検討 (2018)
  • Author(s): Yuki Noguchi, Akifumi Nakatani, Shiina Iwai, Yuta Suzuki, Sae Shimada, Masamitsu Mikami, Katsutsugu Umeda, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo
  • Organizer: 第60回日本小児血液・がん学会学術集会
• [Presentation] 肝芽腫に対するCD146をターゲットとした新規治療の開発 (2018)
  • Author(s): Mari Sonoda, Katsutsugu Umeda, Seishiro Nodomi, Satoshi Obu, Satoshi Saida, Itaru Kato, Hidefumi Hiramatsu, Eri Ogawa, Shinya Okamoto, Ken MOrita, Yasuhiko Kamikubo, Souichi Adachi, Tatsutoshi Nakahata, Hideaki Okajima, Shinji Uemoto, Junko Takita,
  • Organizer: 第60回日本小児血液・がん学会学術集会
• [Presentation] 児悪性腫瘍患者の終末期における苦痛緩和のための持続的鎮静 (2018)
  • Author(s): Sayaka Maeda, Itaru Kato, Katsutsugu Umeda, Hidefumi Hiramatsu, Souichi Adachi, Junko Takita, Satoru Tsuneto
  • Organizer: 第60回日本小児血液・がん学会学術集会
• [Presentation] 中枢神経浸潤白血病異種移植マウスモデルにおけるpiggyBac CD19 CAR-T細胞の脳室内投与の安全性と有効性の検討 (2018)
  • Author(s): 田中邦昭、加藤 格、田中美幸、盛田大介、高橋義行、梅田雄嗣、平松英文、中畑龍俊、足立壮一、滝田順子
  • Organizer: 第60回日本小児血液・がん学会学術集
• [Presentation] .RUNX1 positively regulates Erb2/HER2 signaling pathway through modulating the expression of SOS1 in gastric cancer cells. (2017)
  • Author(s): Mitsuda Y, Morita K, Maeda S, Suzuki K, Kashiwazaki G, Taniguchi J, Bando T, Sugiyama H, Adachi S, Kamikubo Y
  • Organizer: AACR Annual Meeting
  • Int'l Joint Research
• [Presentation] RUNX1 controls EGFR signaling pathway in non-small cell lung cancers. (2017)
  • Author(s): Matsuo A, Morita K, Maeda S, Suzuki K, Kashiwazaki G, Taniguchi J, Bando T, Sugiyama H, Adachi S, Kamikubo Y
  • Organizer: AACR Annual Meeting
  • Int'l Joint Research
• [Presentation] .RUNX1 enhances leukemia cell engraftment in the vascular niche through up-regulating E-selectin. (2017)
  • Author(s): Tokushige C, Morita K, Maeda S, Kiyose H, Noura M, Bando T, Hirata M, Kataoka T, Sugiyama H, Kamikubo Y, Adachi S
  • Organizer: American Society of Hematology 59th Annual Meeting
  • Int'l Joint Research
• [Presentation] Characteristics and outcome of children with acute myeloid leukemia and Down syndrome ineligible for clinical studies. (2017)
  • Author(s): Nakashima K, Hasegawa D, Miyamura T, Hama A, Iwamoto S, Terui K, Tomizawa D, Adachi S, Taga T:
  • Organizer: 49th Congress of the International Society of Paediatric Oncology (SIOP)
  • Int'l Joint Research
• [Presentation] Effectiveness of Supportive Care Measurements to Reduce Infections during Induction for Children with Acute Myeloid Leukemia: A Report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG). (2017)
  • Author(s): Hasegawa D, Miyamura T, Nagai K, Kudo K, Akio T, Sano H, Fukushima K, Iwamoto S, Kinoshita A, Takahashi H, Terui K, Nakayama H, Arakawa Y, Nakashima K, Yamamoto S, Moriya Saito A, Horibe K, Tomizawa D, Taga T, Adachi S:
  • Organizer: American Society of Hematology 59th Annual Meeting
  • Int'l Joint Research
• [Presentation] Cell-Autonoumous Feedback loop of RUNX-p53 CBFb in Acute Myelogous Leukemia Cells. (2017)
  • Author(s): Noura M, Morita K, Tokushige C, Maeda S, Kiyose H, Bando T, Yoshida K, Matsuo H, Ogawa S, Liu P.P, Sugiyama H, Kamikubo Y, Adachi S
  • Organizer: American Society of Hematology 59th Annual Meeting
  • Int'l Joint Research
• [Presentation] RNA Sequencing Illustrates the Genetic Backgrounds of Pediatric Acute Myeloid Leukemia. (2017)
  • Author(s): Shiba N, Yoshida K, Hara Y, Yamato G, Sanada M, Shiraishi Y, Ohki K, Okubo J, Park M-J, Tomizawa D, Taki T, Sotomatsu M, Horibe K, Taga T, Adachi S, Tawa A, Miyano S, Ogawa S, Hayashi Y
  • Organizer: American Society of Hematology 59th Annual Meeting
  • Int'l Joint Research
• [Presentation] Biology and Prognostic Markers in Young Children with Acute Myeloid Leukemia -the JCCG Study, JPLSG AML-05-. (2017)
  • Author(s): Hara Y, Shiba N, Yamato G, Okubo J, Ohki K, Park M-J, Sotomatsu M, Tomizawa D, Taki T, Kinoshita A, Kiyokawa N, Taga T, Arakawa H, Tawa A, Horibe K, Adachi S, Hayashi Y
  • Organizer: American Society of Hematology 59th Annual Meeting
  • Int'l Joint Research
• [Presentation] Comprehensive Methylation Analysis in Pediatric Patients with Acute Myeloid Leukemia ;the JCCG Study, JPLSG AML05. (2017)
  • Author(s): Yamato G, Kawai T, Shiba N, Ohki K, Hara Y, Kiyokawa, MD, Tomizawa D, Shimada A, Okubo J, Park M-J, Sotomatsu M, Arakawa H, Adachi S, Taga T, Horibe K, Hata K, Hayashi Y
  • Organizer: American Society of Hematology 59th Annual Meeting
  • Int'l Joint Research
• [Presentation] Clinical Features and Prognostic Impact of RUNX1 and PTPN11 Mutations in Pediatric Acute Leikemia;the JCCG Study, JPLSG AML05. (2017)
  • Author(s): Yamato G, Shiba N, Yoshida K, Hara Y, Ohki K, Okubo J, Park M-J, Sotomatsu M, Taki T, Arakawa H, Kiyokawa N, Tomizawa D, Adachi S, Taga T, Horibe3 K, Ogawa S, Hayashi Y
  • Organizer: American Society of Hematology 59th Annual Meeting
  • Int'l Joint Research
• [Remarks] 血液生体防御学研究室
  • URL: http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/mt0302/
• [Remarks]
  • URL: https://adachilab-kyotouniv.amebaownd.com/
• [Remarks]
  • URL: http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/mt0302/
• [Remarks] 血液・生体防御研究室
  • URL: http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/mt0302/