|Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
|Outline of Final Research Achievements
Pyrethroid (PYR) is one of the main insecticides used not only in agriculture fields but also household environments and public places. We focused on the exposure assessment of transfluthrin, metofluthrin, profluthrin, and the other PYRs. A sensitive and efficient procedure for the high-throughput determination of nine urinary metabolites of pyrethroids such as 2,3,5,6-tetrafluorobenzyl alcohol (FB-Al), 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol (CH3-FB-Al), 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol (CH3OCH2-FB-Al), and 2,3,5,6-tetrafluoro-1,4-benzenedimethanol (HOCH2-FB-Al) has been developed using GC-MS/MS.Moreover, we revealed that exposure level to some PYRs has increased over the past decade, and that children are exposed to higher levels of hygiene-PYRs in summer than in winter.