| Project/Area Number |
17H04175
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
OUCHI Noriyuki 名古屋大学, 医学系研究科, 寄附講座教授 (00595514)
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| Co-Investigator(Kenkyū-buntansha) |
大橋 浩二 名古屋大学, 医学系研究科, 寄附講座講師 (10595515)
柴田 玲 名古屋大学, 医学系研究科, 寄附講座教授 (70343689)
室原 豊明 名古屋大学, 医学系研究科, 教授 (90299503)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 虚血性心疾患 / 循環器・高血圧 / 運動 / 運動療法 |
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| Outline of Final Research Achievements |
Here we investigated the role of the exercise-induced myokine myonectin in regulation of ischemic heart disease. We found that myonectin knockout mice had increased myocardial infarct size and reduced cardiac function following ischemia-reperfusion compared with control mice, which were accompanied by enhanced apoptosis and inflammatory response in ischemic heart. In contrast, myonectin transgenic mice had reduced ischemia reperfusion injury compared with control mice. Furthermore, myonectin prevented myocardial ischemic injury by reducing cardiomyocyte apoptosis and macrophage inflammatory response through its ability to promote the sphingosine-1-phosphate/cyclicAMP/Akt signaling pathway. Thus, myonectin can function as an exercise-induced myokine which provides cardioprotection.
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| Academic Significance and Societal Importance of the Research Achievements |
我が国において虚血性心疾患を代表とする心血管病の病態解明及び治療法の確立は最重要課題である。本研究において、運動誘発性の骨格筋由来分泌因子「マイオカイン」であるマイオネクチンが心筋細胞のアポトーシスとマクロファージの炎症反応の抑制を介して心筋虚血再灌流障害を改善することが明らかとなった。従って、マイオネクチンは心筋保護作用を有するマイオカインでありマイオネクチンを標的とした心血管病の創薬開発が期待される。
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