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Development of the new technology of fertility preservation for the AYA cancer patients

Research Project

Project/Area Number 17H04342
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

Nao Suzuki  聖マリアンナ医科大学, 医学部, 教授 (90246356)

Co-Investigator(Kenkyū-buntansha) 杉下 陽堂  聖マリアンナ医科大学, 医学研究科, 講師 (20587745)
塚田 孝祐  慶應義塾大学, 理工学部(矢上), 准教授 (00351883)
高江 正道  聖マリアンナ医科大学, 医学部, 講師 (00621301)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords卵巣組織凍結保存 / 妊孕性温存療法 / 小児・AYA世代がん / がん・生殖医療 / がんサバイバーシップ / 耐凍剤 / 卵巣輸送 / 凍結保護剤 / 卵巣組織凍結 / 緩慢凍結法 / ガラス化凍結法 / 生殖医学 / 生殖医療 / 卵巣組織移植 / 卵巣予備能 / 精巣組織凍結
Outline of Final Research Achievements

In recent years, the number of childhood and AYA (Adolescent and Young Adult is the age from 15 to 39 years old) generation cancer survivors who have overcome cancer has been increasing with the progress of multidisciplinary treatment in cancer treatment. On the other hand, cancer treatment for childhood and AYA (CAYA) cancer patients may cause gonadal dysfunction or loss of fertility depending on the treatment method. In Japan, fertility-preserving therapy before the start of cancer treatment for some female CAYA cancer patients has recently been introduced. Ovarian tissue cryopreservation, the only fertility-preserving therapy for children and adolescents with cancer, requires long-term storage for more than 10 years. As a result of this research, we succeeded in developing a new storage system that ensures the safety against human error in the long-term storage system and obtained the results showing the safety of antifreeze for long-term storage.

Academic Significance and Societal Importance of the Research Achievements

近年、がん治療の進歩に伴いがんを克服した小児・AYA世代がんサバイバーが増加している。一方、一部のがん治療によって卵巣や精巣の機能が低下することで、将来の患者の妊孕性の喪失(卵子や精子の数が減少し、がん治療後に子供を授かることが不可能になってしまうこと)等を引き起こす場合がある。我々は、小児・AYA世代のがん医療の充実とがんサバイバーシップ向上(将来子供を授かる選択肢を残す試み)に主眼をおいて研究を進めてきた。本研究成果は、①新たな妊孕性温存技術である卵巣組織凍結保存の安全性を明らかにしたこと、②安全な長期保管体制の構築に寄与すること、から学術的・社会的意義が高いものと確信している。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (10 results)

All 2020 2019 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Radiofrequency identification tag system improves the efficiency of closed vitrification for cryopreservation and thawing of bovine ovarian tissues2019

    • Author(s)
      Sato T, Sugishita Y, Suzuki Y, Kashiwagi M, Furuyama S, Nishimura S, Uekawa A, Koizumi T, Awaji M, Sawa T, Tozawa A, Komatsu V, Suzuki N
    • Journal Title

      Journal of Assisted Reproduction and Genetics

      Volume: 36 Issue: 11 Pages: 2251-2257

    • DOI

      10.1007/s10815-019-01599-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accuracy and safety verification of ovarian reserve assessment technique for ovarian tissue transplantation using optical coherence tomography in mice ovary2017

    • Author(s)
      Seido Takae, Kosuke Tsukada, Yorino Sato, Naoki Okamoto, Tai Kawahara, Nao Suzuki
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 43550-43550

    • DOI

      10.1038/srep43550

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] The analysis of residual cryoprotectants in the thawed ovarian tissue for ovarian tissue transplantation2020

    • Author(s)
      Sugishita Y, Suzuki Y, Meng L, Uekawa A, Tozawa A, Hasegawa J, Suzuki N
    • Organizer
      第72回日本産科婦人科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The quantification of residual cryoprotectants in the thawed ovarian tissue for ovarian tissue transplantation2019

    • Author(s)
      Sugishita Y, Suzuki-Takahashi Y, Nishimura S, Meng L, Sekiguchi M, Uekawa A, Tozawa-Ono A, Edashige K, Suzuki N
    • Organizer
      The 6th World Congress of the International Society for Fertility Preservation
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 卵巣組織移植術における融解卵巣組織内の凍結保護剤遺残に関する安全性の検討2019

    • Author(s)
      杉下陽堂、鈴木由妃、柏木 恵、古山紗也子、鈴木 直
    • Organizer
      第64回日本生殖医学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The quantification of residual cryoprotectants in the thawed ovarian tissue for ovarian tissue transplantation2019

    • Author(s)
      Sugishita Y, Suzuki-Takahashi Y, Nishimura S, Meng L, Uekawa A, Tozawa-Ono A, Edashige K, Suzuki N
    • Organizer
      The 56th Annual Meeting of the Society for Cryobiology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] AYA世代がん患者に対する卵巣組織移植術における融解卵巣組織内の凍結保護剤遺残に関する安全性の検討2019

    • Author(s)
      杉下陽堂、上川篤志、鈴木由妃、佐藤匠、戸澤晃子、鈴木直
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 卵巣組織移植術における融解卵巣組織内の凍結保護剤遺残に関する安全性の検討2019

    • Author(s)
      杉下陽堂,鈴木由妃,柏木恵,古山紗也子,上川篤志,戸澤晃子,鈴木直
    • Organizer
      第19回日本生殖工学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] AYA世代がん患者に対する卵巣組織移植術における融解卵巣組織内の凍結保護剤遺残に関する安全性の検討2019

    • Author(s)
      杉下陽堂,上川篤志,鈴木由妃,佐藤匠,戸澤晃子,鈴木直
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 妊孕性温存治療の最前線2017

    • Author(s)
      高江正道
    • Organizer
      JSAWI2017
    • Related Report
      2017 Annual Research Report
    • Invited

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Published: 2017-04-28   Modified: 2021-02-19  

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