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Study of dynamics of molecular chirality by developing chiral-sensitive time-resolved spectroscopy

Research Project

Project/Area Number 17H04865
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Physical chemistry
Research InstitutionThe University of Tokyo (2019)
University of Tsukuba (2017-2018)

Principal Investigator

Okuno Masanari  東京大学, 大学院総合文化研究科, 准教授 (00719065)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2017: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywordsキラリティー / 非線形分光 / 和周波発生 / 表面・界面 / ハイパーラマン分光 / 振動分光 / 時間分解分光 / 非線形分光法 / 界面・表面 / 分子分光
Outline of Final Research Achievements

In this research, I have developed a new nonlinear spectroscopy enabling us to detect chirality with very high sensitivity. Heterodyne-detected chiral vibrational sum frequency generation (HD-chiral VSFG) spectroscopy in the transmission geometry has been developed for the first time. So far, conventional chiral spectroscopies such as vibrational circular dichroism (VCD) require tens of minutes to obtain vibrational spectra reflecting chirality from typical chiral liquids. HD-chiral VSFG spectroscopy in transmission has enabled us to measure the same sample only within one second, meaning that the sensitivity has been improved more the 100 times.
In addition, I have proposed a new approach to determine the spatial origin of chiral VSFG signals, whether it comes from bulk or an interface. Also I show that under the strict electronic nonresonant condition, chiral VSFG spectroscopy can be interface-specific.

Academic Significance and Societal Importance of the Research Achievements

本研究では、ヘテロダイン検出キラル振動和周波発生分光法を用いることで、従来のキラティーを研究する振動分光法と比較して、はるかに高感度なキラリティー検出を可能にした。多くの生体分子はキラリティーを持つため、キラリティーの検出およびエナンチオマー(鏡像異性体)の区別は生物・医薬分野において重要である。本手法をさらに発展させることにより、生体分子のキラリティーの高感度検出も可能になると考えられる。さらに近年、単分子膜レベルでのキラリティーによる物性制御が行われつつある。本研究で開発した手法は、単分子レベルのキラリティーも容易に検出・区別可能であり、今後物性分野でも使われる可能性が大きいと考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (32 results)

All 2020 2019 2018 2017

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 1 results) Presentation (26 results) (of which Int'l Joint Research: 3 results,  Invited: 7 results)

  • [Journal Article] Hyper-Raman spectroscopy of polar liquids excited at 1064 nm: Acetone, acetonitrile, chloroform, and dimethyl sulfoxide2020

    • Author(s)
      Okuno Masanari
    • Journal Title

      The Journal of Chemical Physics

      Volume: 152 Issue: 17 Pages: 174202-174202

    • DOI

      10.1063/5.0004755

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen Bonds and Molecular Orientations of Supramolecular Structure between Barbituric Acid and Melamine Derivative at the Air/Water Interface Revealed by Heterodyne-Detected Vibrational Sum Frequency Generation Spectroscopy2020

    • Author(s)
      Masanari Okuno, Shuhei Yamada, Tatsuhiko Ohto*, Hirokazu Tada, Waka Nakanishi, Katsuhiko Ariga, Taka-aki Ishibashi*
    • Journal Title

      The Journal of Physical Chemistry Letters

      Volume: 11 Issue: 7 Pages: 2422-2429

    • DOI

      10.1021/acs.jpclett.0c00329

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bulk-or-interface assignment of heterodyne-detected chiral vibrational sum frequency generation signal by its polarization dependence2018

    • Author(s)
      Masanari Okuno, Taka-aki Ishibashi
    • Journal Title

      The Journal of Chemical Physics

      Volume: 149 Issue: 24 Pages: 244703-244703

    • DOI

      10.1063/1.5063290

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Heterodyne-detected Total Internal Reflection Vibrational Sum Frequency Generation Spectroscopy and its Application to CaF2 / Liquid Interfaces2017

    • Author(s)
      N. Takeshita, M. Okuno and T. Ishibashi
    • Journal Title

      Journal of Physical Chemistry C

      Volume: 121 Issue: 45 Pages: 25206-25214

    • DOI

      10.1021/acs.jpcc.7b08212

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Symmertic Raman Tensor Contributes to Chiral Vibrational Sum Frequency Generation from Binaphthyl Amphilphile Monolayers on Water -Study of Electronic Resonance Amplitude and Phase Profiles-2017

    • Author(s)
      4.M. Okuno, D. Ishikawa, W. Nakanishi, K. Ariga and T. Ishibashi
    • Journal Title

      Journal of Physical Chemistry C

      Volume: 121 Issue: 21 Pages: 11241-11250

    • DOI

      10.1021/acs.jpcc.6b12664

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular conformation of DPPC phospholipid Langmuir and Langmuir-Blodgett monolayers studied by heterodyne-detected vibrational sum frequency generation spectroscopy2017

    • Author(s)
      Naoki Takeshita, Masanari Okuno, Taka-aki Ishibashi*
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 19 Issue: 3 Pages: 2060-2066

    • DOI

      10.1039/c6cp07800a

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 二次非線形光学過程に基づく 界面とキラリティーの分子分光2019

    • Author(s)
      奥野将成
    • Organizer
      第9回光科学異分野横断萌芽研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] HD-キラルVSFG分光法を用いた既知の二次構造を持つモデルペプチド界面の分子配向の研究2019

    • Author(s)
      板垣信人、奥野将成、石橋孝章
    • Organizer
      第12回分子科学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 空気/陽・陰イオン性混合界面活性剤水溶液界面の水分子のHD-VSFG分光2019

    • Author(s)
      佐々木伸一、奥野将成、石山達也、森田明弘、石橋孝章
    • Organizer
      第12回分子科学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヘテロダイン検出振動和周波発生分光によるキラリティー検出2018

    • Author(s)
      奥野将成, 石橋孝章
    • Organizer
      日本分光学会年次講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] モデルペプチドの二次構造と気水界面のHD-キラルVSFG信号の相関の研究2018

    • Author(s)
      板垣信人, 奥野将成, 石橋孝章
    • Organizer
      日本分光学会年次講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] HD-VSFG分光法による空気/混合界面活性剤水溶液界面の水の配向の研究2018

    • Author(s)
      佐々木伸一, 奥野将成, 石橋孝章
    • Organizer
      日本分光学会年次講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヘテロダイン検出振動和周波発生分光法による脂質二分子膜の構造の研究2018

    • Author(s)
      鍛冶美里, 奥野将成, 石橋孝章
    • Organizer
      日本分光学会年次講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 振動和周波発生分光法でみえること2018

    • Author(s)
      奥野将成
    • Organizer
      関東光科学若手研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Contributions of Symmetric and Anti-symmetric Raman Tensors to Chiral Vibrational SFG signals2018

    • Author(s)
      Taka-aki Ishibashi, Masanari Okuno
    • Organizer
      The 26th International Conference on Raman Spectroscopy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] High Sensitive Chiral Discrimination by Heterodyne-Detected VSFG Spectroscopy2018

    • Author(s)
      Taka-aki Ishibashi, Masanari Okuno
    • Organizer
      6th International Conference on Vibrational Optical Activity
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] HD-VSFG分光法で観測された空気/混合界面活性剤水溶液界面の水分子の配向のアルキル鎖長依存性2018

    • Author(s)
      佐々木伸一, 奥野将成, 石橋孝章
    • Organizer
      第12回分子科学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 既知の二次構造を持つモデルペプチド界面のHD-キラルVSFG分光2018

    • Author(s)
      佐々木伸一, 奥野将成, 石橋孝章
    • Organizer
      第12回分子科学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 固体/液体界面における支持脂質二分子膜のHD-VSFG分光2018

    • Author(s)
      鍛冶美里, 奥野将成, 石橋孝章
    • Organizer
      第12回分子科学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 和周波発生分光におけるバルク四重極効果の検討2018

    • Author(s)
      森渉, 近藤正人, 奥野将成, 王琳, 石橋孝章, 森田明弘
    • Organizer
      第12回分子科学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 透過配置でのヘテロダイン検出キラル振動和周波発生分光法2018

    • Author(s)
      奥野将成, 石橋孝章
    • Organizer
      第12回分子科学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 全内部反射測定に向けた近赤外超広帯域マルチプレックスCARS分光装置の構築2018

    • Author(s)
      石川将之, 奥野将成, 石橋孝章
    • Organizer
      第12回分子科学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Chiral VSFG Spectroscopy of Polylactic Acid Films2018

    • Author(s)
      石橋孝章, 奥野将成
    • Organizer
      第8回SFG研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] バルク中および空気/溶液界面におけるポルフィリンJ会合体のキラリティー2017

    • Author(s)
      奥野将成、石橋孝章
    • Organizer
      第11回分子科学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 振動和周波発生分光で観るナトリウムポンプロドプシンの気水界面での構造および配向変化ダイナミクス2017

    • Author(s)
      近藤正人、奥野将成、井上圭一、神取秀樹、石橋孝章
    • Organizer
      第11回分子科学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 全内部反射測定のための超広帯域マルチプレックスCARS分光装置の構築2017

    • Author(s)
      石川将之、奥野将成、石橋孝章
    • Organizer
      第11回分子科学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] HD-VSFG分光法によるメラミン誘導体単分子膜と溶質のつくる特異的な水素結合ネットワークの研究2017

    • Author(s)
      山田周平、奥野将成、中西和嘉、有賀克彦、石橋孝章
    • Organizer
      第11回分子科学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヘテロダイン検出振動和周波発生分光法による抗菌ペプチド-グラミシジン-の L 膜および LB 単分子膜の構造の研究2017

    • Author(s)
      鍛治美里、奥野将成、石橋孝章
    • Organizer
      第11回分子科学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Heterodyne-detected chiral VSFG spectroscopy: New, sensitive vibrational chiroptical technique for bulk and interface samples2017

    • Author(s)
      Taka-aki Ishibashi, Masanari Okuno
    • Organizer
      Asian Spectroscopy Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] HD-VSFG分光法による界面での抗菌ペプチド-グラミシジン-の構造の研究2017

    • Author(s)
      鍛治美里、奥野将成、石橋孝章
    • Organizer
      日本分光学会年次講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 固体-液体界面測定のための全内部反射CARS分光装置の試作2017

    • Author(s)
      石川将之、奥野将成、石橋孝章
    • Organizer
      日本分光学会年次講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヘテロダイン検出振動SFG分光による気水界面上のメラミン誘導体-バルビツール酸水素結合ネットワークの解析2017

    • Author(s)
      山田周平、奥野将成、中西和嘉、有賀克彦、石橋孝章
    • Organizer
      日本分光学会年次講演会
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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