| Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we conducted to elucidate the plasmalogen biosynthetic mechanism in gut microbes. We revealed that most of plasmalogens were ethanolamine-type plasmalogens (PlsEtn), the top 10 molecular species accounted for about 90% of the total PlsEtn, and no PlsEtn with a polyunsaturated fatty acid bound at the sn-2 position, like human type plasmaloges.
No Δ1'-desaturase homolog gene was found in these strains which accumulated some plasmalogens. The addition of dioleoylphosphatidylethanolamine to the medium did not change the plasmalogen composition. In addition, low correlation between the distribution of molecular species of PE and PlsEtn in these bacteria. These results strongly suggested that the plasmalogen biosynthetic pathway in gut microbes is different from that in humans.
|
