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Analysis of the effect of inseparable association of AIM with IgM on obesity-related diseases

Research Project

Project/Area Number 17H06624
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

SUGISAWA Ryoichi  東京大学, 大学院医学系研究科(医学部), 特任助教 (70803568)

Research Collaborator MIYAZAKI Toru  
ARAI Satoko  
Project Period (FY) 2017-08-25 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords肥満 / 脂肪肝 / 肝癌 / AIM / ネコ / 病態医科学 / 免疫学 / 蛋白質
Outline of Final Research Achievements

Apoptosis inhibitor of macrophage (AIM) has been shown to have suppressive functions in a broad range of diseases including obesity, liver steatosis, hepatocellular carcinoma, and acute kidney injury (AKI). AIM is a circulating protein, associate with IgM pentamers under health states in the blood, and during AKI, AIM dissociates from IgM and gains disease repair activity. On the other hand, due to its extremely high binding affinity for IgM, feline AIM rarely dissociates from IgM and AIM-felinized mice (mice which mouse AIM was replaced with feline AIM) exhibited deficient AKI repair as in cats. In this study, we investigated whether AIM activation via its release from IgM is required to ameliorate other diseases. When fed a high-fat diet (HFD), AIM-felinized mice exhibited resulting in more prominent obesity and fatty liver than in wild-type mice. Thus, blood AIM released from IgM contributes to suppression of obesity and fatty liver as in AKI.

Report

(2 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (1 results)

All 2017

All Presentation (1 results)

  • [Presentation] ネコAIM独自のIgM高親和性が肥満病態に及ぼす影響の検討2017

    • Author(s)
      杉澤良一、新井聡子、宮崎徹
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report

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Published: 2017-08-25   Modified: 2019-03-29  

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