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The mechanisms about the cell aggregation of IgE-producing cells

Research Project

Project/Area Number 17H06765
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionMie University

Principal Investigator

Kuniishi Mari  三重大学, 医学系研究科, 助教 (70804326)

Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsIgE / I型アレルギー疾患 / 凝集 / Fc gamma receptors / 細胞凝集 / 抗体産生 / 形質細胞
Outline of Final Research Achievements

IgE producing cells are related to type I hypersensitivity, but little is known about the specific phenotype of IgE producing cells. we focused on the cell aggregation of IgE-producing cells via antigen-IgE bound FcgRII/FcgRIII. This cell aggregation was observed only in IgE-producing cells by using IgE-producing cell line. Here, we examined where IgE-producing cells aggregated and whether these cells expressed FcgRII/FcgRIII in vivo. We showed that IgE-producing cells are present in spleen, mesenteric lymph node and thymus of antigen/alum-administrated mice, but the cell aggregation was found only in spleen. Furthermore, we found the expression of FcgRIII on antibody poruding cells. In this study, we obtained the new finding about the phenotype of IgE producing cells.

Academic Significance and Societal Importance of the Research Achievements

IgE産生細胞は他のクラスの抗体産生細胞に比べて、生体内での検出頻度がかなり低く、細胞の局在や抗体産生のメカニズムについて不明な点が多かった。本研究成果は、これまでに報告のあったIgE産生細胞の局在に加え胸腺での局在を明らかにした。血中のIgE抗体の産生はIgE産生細胞によって制御されることから、IgE産生細胞の特徴を示せた点で学術的な意義は大きいと考える。また、現在アレルギー疾患患者が増加しており根本的治療法の開発が急がれており、本研究成果は今後アレルギー治療の基礎的研究を発展させる上で重要であると考える。

Report

(3 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (7 results)

All 2019 2018

All Presentation (7 results)

  • [Presentation] Involvement of follicular dendritic cells in each LNs with IgA production2019

    • Author(s)
      Mari Hikosaka-Kuniishi, Toshiyuki Yamane, Hidetoshi Yamazaki
    • Organizer
      The 48th Annual Meeting of the Japanese Society for Immunology
    • Related Report
      2018 Annual Research Report
  • [Presentation] 粘膜免疫に関与するリンパ節支持細胞 follicular dendritic cellの検出の試み2019

    • Author(s)
      國石(彦坂)茉里,磯野加奈,山崎英俊
    • Organizer
      第47回 三重歯科・口腔外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Multiple cell populations generate macrophage progenitors in the early yolk sac2019

    • Author(s)
      Toshiyuki Yamane, Mari Hikosaka-Kuniishi, Hidetoshi Yamazaki
    • Organizer
      The 48th Annual Meeting of the Japanese Society for Immunology
    • Related Report
      2018 Annual Research Report
  • [Presentation] The role of Neural crest-derived cells in thymic regeneration2019

    • Author(s)
      Doris Narki Tetteh, Mari Hikosaka-Kuniishi, Toshiyuki Yamane, Hidetoshi Yamazaki
    • Organizer
      The 48th Annual Meeting of the Japanese Society for Immunology
    • Related Report
      2018 Annual Research Report
  • [Presentation] An attempt to detect follicular dendritic cells in ectopic lymphoid tissues2018

    • Author(s)
      Mari Hikosaka, Toshiyuki Yamane, Hidetoshi Yamazaki
    • Organizer
      the 47th annual meeting of the japanese society for immunology
    • Related Report
      2017 Annual Research Report
  • [Presentation] Yolk sac progenitors for tissue-resident macrophages2018

    • Author(s)
      Toshiyuki Yamane, Mari Hikosaka, Hidetoshi Yamazaki
    • Organizer
      the 47th annual meeting of the japanese society for immunology
    • Related Report
      2017 Annual Research Report
  • [Presentation] Depletion of neural crest-derived cells leads to reduction of plasama noradrenalin and alters T lymphopoiesis2018

    • Author(s)
      Hidetoshi Yamazaki, Tsunokuma Naoki, Mari Hikosaka, Toshiyuki Yamane
    • Organizer
      the 47th annual meeting of the japanese society for immunology
    • Related Report
      2017 Annual Research Report

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Published: 2017-08-25   Modified: 2021-02-19  

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