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The association of oral function with systemic disesase and function in the elderly people: Comprehensive analysis by data mining

Research Project

Project/Area Number 17H06850
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Prosthodontics/ Dental materials science and
Research InstitutionOsaka University

Principal Investigator

Mihara Yusuke  大阪大学, 歯学部附属病院, 医員 (30779096)

Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords疫学研究 / 高齢者 / 機械学習 / コホート研究 / 老年学研究 / データマイニング / ニューラルネットワーク / 歯学
Outline of Final Research Achievements

The subjects of this study were 69-71-year-old 1000 and 79-81-year-old 973. An exhaustive analyses were performed to investigate the association of sarcopenia, handgrip strength and walking speed with about 150 survey items such as motor function, presence or absence of systemic disease, blood test results, single nucleotide polymorphism, nutritional status, cognitive function, and oral function, using machine learning. As a result, it was revealed that maximum occlusal force, LDL cholesterol level and neutral fat value were closely related to sarcopenia, sex and red blood cell count and hemoglobin value were closely related to handgrip strength, and footstepping and standing up and handgrip strength were closely related to walking speed.

Academic Significance and Societal Importance of the Research Achievements

近年,サルコペニアやフレイルと全身疾患や口腔機能との関連について様々な研究結果が報告されているが,多人数を対象として,他分野にわたるデータを網羅的に分析し,その関連について明らかとした研究は見られなかった.本研究では,様々な機械学習の手法を用いることで,サルコペニアや握力,歩行速度と関連する項目について網羅的に解析することができた.また,本研究は,これまで統計学的な分析が行われることが多かったコホート研究において,機械学習の手法を用いた点においても意義のある研究であったといえる.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (15 results)

All 2019 2018 2017

All Journal Article (8 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 7 results,  Open Access: 7 results) Presentation (7 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Relationship between oral stereognostic ability and dietary intake in older Japanese adults with complete dentures2019

    • Author(s)
      Fukutake Motoyoshi、Ikebe Kazunori、Okubo Hitomi、Matsuda Ken-ichi、Enoki Kaori、Inomata Chisato、Takeshita Hajime、Mihara Yusuke、Hatta Kodai、Gondo Yasuyuki、Kamide Kei、Masui Yukie、Ishizaki Tatsuro、Arai Yasumichi、Maeda Yoshinobu
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 63 Issue: 1 Pages: 105-109

    • DOI

      10.1016/j.jpor.2018.10.001

    • NAID

      130007604164

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lack of posterior occlusal support predicts the reduction in walking speed in 80‐year‐old Japanese adults: A 3‐year prospective cohort study with propensity score analysis by the SONIC Study Group2019

    • Author(s)
      Hatta Kodai、Ikebe Kazunori、Mihara Yusuke、Gondo Yasuyuki、Kamide Kei、Masui Yukie、Sugimoto Ken、Matsuda Ken‐ichi、Fukutake Motoyoshi、Kabayama Mai、Shintani Ayumi、Ishizaki Tatsuro、 Arai Yasumichi、Rakugi Hiromi、Maeda Yoshinobu
    • Journal Title

      Gerodontology

      Volume: - Issue: 2 Pages: 156-162

    • DOI

      10.1111/ger.12393

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of handgrip strength with various oral functions in 82- to 84-year-old communitydwelling Japanese2018

    • Author(s)
      Mihara Yusuke、Matsuda Ken-ichi、Ikebe Kazunori、Hatta Koudai、Fukutake Motoyoshi、Enoki Kaori、Ogawa Taiji、Takeshita Hajime、Inomata Chisato、Gondo Yasuyuki、Masui Yukie、Kamide Kei、Sugimoto Ken、Kabayama Mai、Ishizaki Tatsuro、Arai Yasumichi、Maeda Yoshinobu
    • Journal Title

      Gerodontology

      Volume: 35 Issue: 3 Pages: 214-220

    • DOI

      10.1111/ger.12341

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationship between gerotranscendence and oral health-related quality of life2018

    • Author(s)
      Mihara Yusuke、Matsuda Ken-ichi、Hatta Koudai、Gondo Yasuyuki、Masui Yukie、Nakagawa Takeshi、 Kamide Kei、Ishizaki Tatsuro、Arai Yasumichi、Maeda Yoshinobu、Ikebe Kazunori
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 45 Issue: 10 Pages: 805-809

    • DOI

      10.1111/joor.12691

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of lack of posterior occlusal support on cognitive decline among 80-year-old Japanese pople in a 3-year prospective study2018

    • Author(s)
      Hatta K、Ikebe K、Gondo Y、Kamide K、Masui Y、Inagaki H、Nakagawa T、Matsuda K、Ogawa T、 Inomata C、Takeshita H、Mihara Y、Fukutake M、Kitamura M、Murakami S、Kabayama M、Ishizaki T、 Arai Y、Sugimoto K、Rakugi H、Maeda Y
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 18 Issue: 10 Pages: 1439-1446

    • DOI

      10.1111/ggi.13508

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of handgrip strength with various oral functions in 82 to 84-year-old community-dwelling Japanese2018

    • Author(s)
      Yusuke Mihara, Ken-ichi Matsuda, Kazunori Ikebe, Koudai Hatta, Motoyoshi Fukutake, Kaori Enoki, Taiji Ogawa, Hajime Takeshita, Chisato Inomata, Yasuyuki Gondo, Yukie Masui, Kei Kamide, Ken Sugimoto, Mai Kabayama, Tatsuro Ishizaki, Yasumichi Arai, Yoshinobu Maeda
    • Journal Title

      Gerodontology

      Volume: in press

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary intake is associated with occlusal force rather than number of teeth in 80-year-old Japanese.2017

    • Author(s)
      Inomata C, Ikebe K, Okubo H, Takeshita H, Mihara Y, Hatta K, Tada S, Enoki K, Ogawa T, Matsuda K, Gondo Y, Masui Y, Kamide K, Takahashi R, Arai Y, Maeda Y.
    • Journal Title

      JDR Clinical & Translational Research

      Volume: 2 Pages: 187-197

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 健康寿命の延伸には何がどの程度重要となるの か? 歯科からの報告 健康長寿の要因の探求.2017

    • Author(s)
      池邉一典*,三原佑介,猪俣千里,小川泰治,榎木香織,岡田匡史,松田謙一, 武下 肇,北村正博.
    • Journal Title

      歯界展望

      Volume: 130 Pages: 32-41

    • Related Report
      2017 Annual Research Report
  • [Presentation] 機械学習を用いた運動機能と全身指標ならびに口腔機能との関連についての検討2018

    • Author(s)
      三原佑介,野崎一徳,八田昂大,福武元良,佐藤仁美,権藤恭之,神出 計,増井幸恵,石崎達郎,新井康通,池邉一典
    • Organizer
      日本サルコペニア・フレイル学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Occlusal contacts predict decline in cognitive decline in 3-years2018

    • Author(s)
      Hatta K, Matsuda K, Gondo Y, Kamide K, Masui Y, Ishizaki T, Arai Y, Sugimoto K, Mihara Y, Inomata C, Takeshita H, Enoki K, Fukutake M, Sato H, Maeda Y, Ikebe K
    • Organizer
      International Association for Dental Research
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Influence of occlusal force on malnutrition in older adults.2018

    • Author(s)
      Fukutake M, Hatta K, Sato H, Mihara Y, Inomata C, Takeshita H, Enoki K, Matsuda K, Gondo Y, Kamide K, Arai Y, Ishizaki T, Masui Y, Maeda Y, Ikebe K
    • Organizer
      International Association for Dental Research
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 無歯顎者群はすれ違い咬合者群よりも口腔関連QOLは低いのか?2018

    • Author(s)
      佐藤仁美,松田謙一,小川泰治,榎木香織,猪俣千里,武下肇,三原佑介,八田昂大,福武元良,前田芳信,池邉一典
    • Organizer
      平成29年度日本補綴歯科学会関西支部総会ならびに学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高齢者における最大咬合力と運動習慣との関連について2017

    • Author(s)
      三原佑介,八田昂大,福武元良,池邉一典,前田芳信
    • Organizer
      第28回日本スポーツ歯科医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 臼歯部咬合支持が歩行速度低下に及ぼす影響についての検討 ―SONIC  Study 3年間の縦断研究より―2017

    • Author(s)
      八田昂大,福武元良,三原佑介,猪俣千里,榎木香織,前田芳信,池邉一典
    • Organizer
      第4回日本サルコペニア・フレイル学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高齢者の最大咬合力と日常の食生活における咀嚼筋活動推定量との関連2017

    • Author(s)
      福武元良,池邉一典,松田謙一,小川泰治,榎木香織,猪俣千里,武下肇,三原佑介,八田昂大,前田芳信
    • Organizer
      第126回日本補綴歯科学会学術大会
    • Related Report
      2017 Annual Research Report

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Published: 2017-08-25   Modified: 2020-03-30  

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