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Elucidation of preventive effect of food factors against hyperglycemia through inhibition of de-SUMO enzymes

Research Project

Project/Area Number 17H06856
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Eating habits
Research InstitutionKonan Women's University (2018)
Kobe University (2017)

Principal Investigator

Yoshioka Yasukiyo  甲南女子大学, 医療栄養学部, 助教 (80801513)

Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords脱SUMO化酵素 / 膵臓 / インスリン / インスリン分泌 / SENP / シナプトタグミン
Outline of Final Research Achievements

We examined the preventive effect of food factors against hyperglycemia related with de-SUMOylation in the pancreas. We found that some methylxanthines changed the expression of de-SUMOylation enzymes using the mouse pancreatic β-cell-derived cell line MIN6 and pancreatic islets isolated from mice. Furthermore, vialinin A (VA), which was found as an inhibitor of de-SUMOylation enzymes, suppressed apoptosis due to oxidative stress in the pancreas. In addition, VA increased the expression level of the antioxidant protein HO-1 through stabilization of Nrf2. From these results, it is predicted that VA inhibits the apoptosis in pancreas through the inhibiton of de-SUMOylation enzymatic activity and increasing the expression of anti-oxidant protein.

Academic Significance and Societal Importance of the Research Achievements

日本では、食の欧米化やライフスタイルの変化により、生活習慣病の罹患者および予備軍が多く、この解消が急務である。その中でも、高血糖および糖尿病に対する抑制効果に関する研究は世界中で行われている。本研究において、膵臓において脱SUMO化酵素の発現を変化させる、もしくは膵臓のアポトーシスを抑制する食品因子を見出した。また、高血糖予防の新たな作用機序として、脱SUMO化酵素の発現量および酵素活性の変化を見出した。本研究の成果は、既存の高血糖予防効果と異なる作用機序であり、新たな機能性食品因子の発見につながることが期待される。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (13 results)

All 2019 2018 2017

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Effects of Microbial Metabolites of (−)-Epigallocatechin Gallate on Glucose Uptake in L6 Skeletal Muscle Cell and Glucose Tolerance in ICR Mice2019

    • Author(s)
      Takagaki Akiko、Yoshioka Yasukiyo、Yamashita Yoko、Nagano Tomoya、Ikeda Masaki、Hara-Terawaki Aya、Seto Ryota、Ashida Hitoshi
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 2 Pages: 212-221

    • DOI

      10.1248/bpb.b18-00612

    • NAID

      130007588655

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-02-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols.2019

    • Author(s)
      Kyuichi Kawabata, Yasukiyo Yoshioka, Junji Terao
    • Journal Title

      Molecules

      Volume: 24 Issue: 2 Pages: 370-370

    • DOI

      10.3390/molecules24020370

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glabridin inhibits dexamethasone-induced muscle atrophy.2019

    • Author(s)
      Yasukiyo Yoshioka, Yusuke Kubota, Yumi Samukawa, Yoko Yamashita, Hitoshi Ashida
    • Journal Title

      Archives of Biochemistry and Biophysics

      Volume: 664 Pages: 157-166

    • DOI

      10.1016/j.abb.2019.02.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Piperine Promotes Glucose Uptake through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle2018

    • Author(s)
      Maeda Ayumi、Shirao Takeshi、Shirasaya Daishi、Yoshioka Yasukiyo、Yamashita Yoko、Akagawa Mitsugu、Ashida Hitoshi
    • Journal Title

      Molecular Nutrition & Food Research

      Volume: 62 Issue: 11 Pages: 1800086-1800086

    • DOI

      10.1002/mnfr.201800086

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Licorice flavonoid oil enhances muscle mass in KK-Ay mice.2018

    • Author(s)
      Yasukiyo Yoshioka, Yoko Yamashita, Hiroyuki Kishida, Kaku Nakagawa, Hitoshi Ashida
    • Journal Title

      Life Sciences

      Volume: 205 Pages: 91-96

    • DOI

      10.1016/j.lfs.2018.05.024

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liquorice flavonoid oil suppresses hyperglycaemia accompanied by skeletal muscle myocellular GLUT4 recruitment to the plasma membrane in KK-Ay mice.2018

    • Author(s)
      Yoko Yamashita, Hiroyuki Kishida, Kaku Nakagawa, Yasukiyo Yoshioka, Hitoshi Ashida
    • Journal Title

      International Journal of Food Sciences and Nutrition

      Volume: 70 Issue: 3 Pages: 294-302

    • DOI

      10.1080/09637486.2018.1508425

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein β degradation by adenosine receptor A12017

    • Author(s)
      Mitani Takakazu、Watanabe Shun、Yoshioka Yasukiyo、Katayama Shigeru、Nakamura Soichiro、Ashida Hitoshi
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

      Volume: 1864 Issue: 12 Pages: 2438-2448

    • DOI

      10.1016/j.bbamcr.2017.09.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 甘草由来グラブリジンの筋萎縮抑制効果2018

    • Author(s)
      吉岡 泰淳, 久保田 祐介, 芦田 均
    • Organizer
      第72回 日本栄養・食糧学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 酵素合成グリコーゲンはRBL-2H3細胞における脱顆粒および炎症性サイトカインの産生を抑制する2018

    • Author(s)
      吉岡泰淳, 井上雅子, 古屋敷隆, 芦田均
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Black soybean seed coat polyphenols prevent fibrosis in the liver of mice via suppression of lipid peroxidation and inhibition of TGF-β/Smads signaling pathway.2017

    • Author(s)
      Yasukiyo Yoshioka, Xiu Li, Yoko Yamashita, Hitoshi Ashida
    • Organizer
      8th International Conference on Polyphenols and Health
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enzymatically-synthesized glycogen inhibits inflammatory response in antigen-induced basophilic and mast cells.2017

    • Author(s)
      Yasukiyo Yoshioka, Takashi Furuyashiki, Hiitoshi Ashida
    • Organizer
      IUNS 21st International Congress of Nutrition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enzymatically Synthesized Glycogen Suppresses Antigen-induced Allergic and Inflammatory Responses in Basophilic Cells.2017

    • Author(s)
      Yasukiyo Yoshioka, Takashi Furuyashiki, Hitoshi Ashida
    • Organizer
      The 10th International Conference and Exhibition on Nutraceuticals and Functional Foods
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] バイオグリコーゲンのI型アレルギー抑制効果2017

    • Author(s)
      吉岡泰淳, 井上雅子, 古屋敷隆, 芦田均
    • Organizer
      第22回日本フードファクター学会学術集会
    • Related Report
      2017 Annual Research Report

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Published: 2017-08-25   Modified: 2020-03-30  

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