| Project/Area Number |
17H06884
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2017-08-25 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯学 / 病的歯槽骨吸収 / SNP解析 / 次世代シーケンサー / ゲノムワイド関連解析 / 骨代謝マーカー / 次世代シークエンサー |
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| Outline of Final Research Achievements |
According to the selection criteria set in advance from the patient list, when the patients were extracted, 174 subjects (mean age 71.8 years old, 82 men, 92 women) were included. Although SNP analysis was tried for these patients, pathological bone resorption of alveolar bone has to be diagnosed from external evaluation such as the alveolar ridge height of panoramic X-ray image, and a problem is found in the validity of the extracted patients The Therefore, we are currently planning a study using software that can quantitatively evaluate alveolar bone density from dental x-ray images. With this software, it is possible to evaluate pathological alveolar bone loss also from bone quality. A more accurate diagnosis of "pathological alveolar bone resorption" was made, leading to the idea that a search for a causative gene based on that is necessary.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果で病的歯槽骨吸収に関連するSNPを含む遺伝子多型が明らかになれば、将来的な骨吸収の予測や、疾患発症メカニズムに基づく生物学的な症型分類ならびに新たな治療法の開発に繋がる可能性があった。しかし、本研究を進めていった中で、「病的歯槽骨吸収」の定義自体に課題があることがわかった。今後はより精度の高い「病的歯槽骨吸収」の診断を行うために、新たな研究を始めており、本研究はその基盤となったので学術的意義を有している。また、「病的歯槽骨吸収」の診断を精度高く行うことができるようになれば、増加している骨粗鬆症の予防に歯科から医科へ繋ぐことができる可能性もあり、高い社会的意義を有している。
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