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Study on evolution of sex chromosome and sex determination system in Hokou gecko

Research Project

Project/Area Number 17H07279
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Evolutionary biology
Research InstitutionKwansei Gakuin University

Principal Investigator

Kazumi Matsubara  関西学院大学, 理工学部, 助教 (90399113)

Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords性染色体の分化 / ヤモリ / 収斂進化 / 性決定遺伝子 / DMRT1 / 性染色体 / 性決定 / 爬虫類 / 進化
Outline of Final Research Achievements

Hokou gecko exhibits genotypic sex determination with ZZ/ZW sex chromosome. In this study, to infer the evolutionary process of the sex chromosomes, sequences of Z and W homologs of two sex chromosome-linked genes, ACO1 and DMRT1, were analyzed for two populations of Hokou gecko, the populations from Okinawa and Ishigaki islands. The former population has morphologically differentiated ZW chromosomes and the latter has undifferentiated ZW chromosomes. Sequences of ACO1 were differentiated between the Z and W homologs in Okinawa population while those were identical between the Z and W homologs in Ishigaki population. In contrast, sequences of DMRT1 were differentiated between the Z and W homologs in commonly both populations. These results suggest that an initial step of sex chromosome differentiation was allelic differentiation of DMRT1 (a sex determining gene in Vertebrate) in the common ancestor. Then, inversions independently occurred in the W chromosome of Okinawa population.

Academic Significance and Societal Importance of the Research Achievements

沖縄本島産と石垣島産ミナミヤモリの性染色体の比較解析から、両島の個体群の性染色体は共通祖先に端を発し、各島に個体群が定着した後に独自の構造変化を蓄積したことが示唆された。島嶼など小さな隔離地域に生息する個体群では独自の性決定様式や生物学的特徴を獲得した可能性があり、これら隔離個体群の調査や保護の重要性が示される。ミナミヤモリの性染色体の分化の開始には、脊椎動物の性分化関連遺伝子であるDMRT1の対立遺伝子間での分化が切掛となったことが示唆された。この事は、脊椎動物の性染色体は多様な起源を持ちつつも、その誕生には性分化関連遺伝子の収斂進化といった共通原理があることを支持する。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (7 results)

All 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (3 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] Karyotype analysis of four blind snake species (Reptilia: Squamata: Scolecophidia) and karyotypic changes in Serpentes2019

    • Author(s)
      Kazumi Matsubara, Yoshinori Kumazawa, Hidetoshi Ota, Chizuko Nishida, Yoichi Matsuda
    • Journal Title

      Cytogenetics and Genome Research

      Volume: 157 Issue: 1-2 Pages: 98-106

    • DOI

      10.1159/000496554

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary process of sex chromosomes and sex determination systems in reptiles2019

    • Author(s)
      Kazumi Matsubara
    • Journal Title

      Chromosome Science

      Volume: 印刷中

    • NAID

      130007682153

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Karyotype analysis of four blind snake species (Reptilia: Squamata: Scolecophidia) and karyotypic changes in Serpentes2018

    • Author(s)
      Kazumi Matsubara, Yoshinori Kumazawa, Hidetoshi Ota, Chizuko Nishida and Yoichi Matsuda
    • Journal Title

      Cytogenetic and Genome Research

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 性染色体相同性の種間比較から推定される爬虫類における性決定様式の進化2018

    • Author(s)
      松原和純
    • Organizer
      第6回 生殖若手の会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 爬虫類におけるゲノム構造および性染色体の進化2017

    • Author(s)
      松原和純
    • Organizer
      染色体学会第68回(2017年度)年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 性染色体相同性の種間比較から推定される爬虫類における性決定様式の進化2017

    • Author(s)
      松原和純
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] 遺伝子から解き明かす性の不思議な世界2019

    • Author(s)
      田中実(編著)大久保範聡、宮副大地、三浦郁夫、伊藤道彦、松原和純、戸張靖子、金井克晃、平松竜司、菊水健史、深見真紀、勝間進、赤木剛士、菊池潔(著)
    • Total Pages
      544
    • Publisher
      一式出版
    • ISBN
      9784909383068
    • Related Report
      2018 Annual Research Report

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Published: 2017-08-25   Modified: 2020-03-30  

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