Induction mechanism of antiviral factors in Kuruma shrimp
| Project/Area Number |
17K07953
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Aquatic life science
|
|---|
| Research Institution | Fisheries Research and Education Agency |
|---|
Principal Investigator |
Mekata Tohru 国立研究開発法人水産研究・教育機構, 増養殖研究所, 主任研究員 (40597944)
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | クルマエビ / 抗ウイルス応答 / トランスクリプトーム / 抗ウイルス因子 / 水産学 / 自然免疫 |
|---|
| Outline of Final Research Achievements |
In order to understand the behavior of antiviral response-related factors in the hemolymph of kuruma shrimp, the identification of the factors and construction of a detection method were examined. It was revealed that highly abundant proteins can be removed by mixing a certain polymer compound with hemolymph. Gene ontology enrichment analysis of hemocytes during the antiviral response confirmed that the transcript levels involved in ribosome biosynthesis and proteolysis was significantly altered.
|
| Academic Significance and Societal Importance of the Research Achievements |
クルマエビのウイルス病を防ぐために、免疫賦活剤や抗ウイルス薬が研究開発されている。エビ類の養殖では様々なウイルス病が蔓延しており、一刻も早い防除対策が望まれている。クルマエビの抗ウイルス作用を持つ物質が発見されているが、その作用機序は不明である。免疫賦活剤の実用化を進めていく上でも、その作用機序の解明が望まれている。
|
Report
(4 results)
Research Products
(7 results)
