Genetic model of hypothyroidism and analysis of pathological mechanism on neuropsychological symptoms
| Project/Area Number |
17K08276
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
Noda Mami 九州大学, 薬学研究院, 准教授 (80127985)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 甲状腺ホルモン / ミクログリア / アストロサイト / 神経シナプススパイン / 性差 / 加齢 / 認知症 / トランスポーター / 甲状腺機能低下症 / 老齢 / 更年期 / うつ / 性ホルモン / 学習・記憶 / シナプススパイン / 行動変化 / 認知機能 / グリア細胞 |
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| Outline of Final Research Achievements |
I focused on the function of thyroid hormone in the central nervous system and the neurological and psychiatric symptoms, and established a new research area called glioendocrinology. While we looked at the effects on the morphology of glial cells and the number and volume of synaptic spines in hyperthyroidism, it is hypothyroidism that increases in aging, especially in elderly women, accompanying with dementia. Therefore, for the prevention and treatment of depression and dementia, a hypothyroidism mouse model was created, and functional morphological changes in the brain, effects on behavior and cognition, and their mechanisms were investigated.
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| Academic Significance and Societal Importance of the Research Achievements |
臨床的に、甲状腺機能異常症は、不安や鬱等の精神症状、高齢では認知症リスクと深い関係があることが報告されているが、細胞レベルでどのようなメカニズムがあるのか、不明であった。本研究は、甲状腺ホルモンが脳機能に与える影響には性差があり、また年齢にも依存していること、マウスを用いた甲状腺機能異常症モデルでは、ヒトの症状と似た行動変化が見られること、脳内では、グリア細胞と神経シナプススパインの形状がメスとオスとで異なることを明らかにした。高齢化社会で増えるウツや認知症の予防には、本研究のような神経・グリア内分泌学の進歩が重要であり、ウツや認知症のメカニズム解明にも大きく貢献すると期待される。
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Gliotransmitters and cytokines in the control of blood-brain barrier permeability.2018
Author(s)
Osipova ED, Semyachkina-Glushkovskaya OV, Morgun AV, Pisareva NV, Malinovskaya NA, Boitsova EB, Pozhilenkova EA, Belova OA, Salmin VV, Taranushenko TE, Noda M, Salmina AB.
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Journal Title
Rev Neurosci.
Volume: 29(5)
Issue: 5
Pages: 567-591
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress.2017
Author(s)
Wu CY, Hsu WL, Tsai MH, Liang JL, Lu JH, Yen CJ, Yu HS, Noda M, Lu CY, Chen CH, Yan SJ, Yoshioka T.
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Journal Title
Sci Rep.
Volume: 7(1): 3606
Issue: 1
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Neuropathic pain inhibitor, RAP-103, is a potent inhibitor of microglial CCL1/CCR8.2017
Author(s)
Noda M, Tomonaga D, Kitazono K, Yoshioka Y, Liu J, Rouseau JP, Kinkead R, Ruff MR, Pert CB.
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Journal Title
Neurochem Int.
Volume: S0197-0186(17)
Pages: 30474-6
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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