Development of optimal interstitial brachytherapy for image guided brachytherapy of uterin cervix cancer.
| Project/Area Number |
17K10488
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Yamazaki Hideya 京都府立医科大学, 医学(系)研究科(研究院), 教授 (50301263)
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| Co-Investigator(Kenkyū-buntansha) |
古妻 理之 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 機関長・部門長クラス (00641870)
吉田 謙 関西医科大学, 医学部, 准教授 (10463291)
酒井 晃二 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (20379027)
増井 浩二 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20783830)
鈴木 弦 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (80279182)
武中 正 京都府立医科大学, 医学(系)研究科(研究院), 助教 (80626771)
清水 大介 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (70453107)
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 放射線治療 / 子宮頸部癌 / 画像誘導小線源治療 / 組織内照射 / 子宮頸癌 / 腔内照射 / MRI / 子宮頚癌 / 放射線 |
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| Outline of Final Research Achievements |
Eighteen patients with stage IIB-IVB cervical cancer (squamous cell carcinoma) were treated with simultaneous chemoradiotherapy using CT-MRI guided multi-catheter interstitial radiation (interstitial bradchytherpy; ISBT) (4 stage II, 7 stage III, 7 stage IV). 4-year local control rate was 100%, pelvic control rate was 100%, disease-free survival rate was 81.6%, and overall survival rate was 87.8%. Grade 3 late adverse events occurred in 3 patients (16.7%), but there were no ISBT-related late adverse events. ISBT can reduce adverse events by reducing bladder and rectal doses and to improve tumor control for large tumors (especially those larger than 4 cm in diameter).
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| Academic Significance and Societal Importance of the Research Achievements |
子宮頸がんの放射線治療はA点線量処方の2次元治療時代からCTを用いた体積線量処方、さらにMRI画像を用いた画像誘導小線源治療時代へと過渡期にある。我々の研究成果により、従来の腔内照射にMRIを用いた3次元治療計画を用いた組織内照射を加える事の利点：有害事象軽減や腫瘍制御率向上の可能性が示唆された。今後どこの施設でも簡便に組織内照射が可能となるような安全・簡便な手技の普及が期待される。
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Report
(7 results)
Research Products
(9 results)
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[Journal Article] 3D-Image-Guided Multi-Catheter Interstitial Brachytherapy for Bulky and High-Risk Stage IIB-IVB Cervical Cancer2022
Author(s)
Kokabu T, Masui K, Tarumi Y, Noguchi N, Aoyama K, Kataoka H, Matsushima H, Yoriki K, Simizu D, Yamazaki H, Yamada K, Mori T
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Journal Title
Cancers
Volume: 14(5)
Issue: 5
Pages: 1257-1257
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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