Novel vaccination targeting stem cells of cervical cancer
| Project/Area Number |
17K11285
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鳥越 俊彦 札幌医科大学, 医学部, 教授 (20301400)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 子宮頸癌 / がん幹細胞 / 免疫療法 / 子宮頸がん / ワクチン療法 / 子宮体がん / ペプチドワクチン / CTL / HPV |
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| Outline of Final Research Achievements |
Cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) are a small subpopulation of cancer cells that are tumorigenic and are resistant to treatments, thus they are focused as treatment targets. We have established sphere-cultured CSCs/CICs from primary human uterine cervical carcinoma, and we isolated several clones from CSCs/CICs in this study. Thus, BORIS sf6 is a cervical CSC/CIC-specific subfamily and has a role in the maintenance of cervical CSCs/CICs. A BORIS C34_24(9)-specific cytotoxic T cell (CTL) clone showed cytotoxicity for BORIS sf6-overexpressing cervical cancer cells. Taken together, the results indicate that the CT antigen BORIS sf6 is specifically expressed in cervical CSCs/CICs, that BORIS sf6 has a role in the maintenance of CSCs/CICs, and that BORIS C34_24(9) peptide is a promising candidate for cervical CSC/CIC-targeting immunotherapy.
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| Academic Significance and Societal Importance of the Research Achievements |
子宮頸癌は比較的若い女性に好発する腫瘍で、これらの若年女性達の子宮頸癌での喪失は、家族の幸福を奪うばかりではなく社会的・経済的な損失も大きい。化学療法や放射線療法に抵抗性の腫瘍も少なくなく新しい治療が望まれるところである。今回の研究はがん幹細胞に対する免疫療法の確立をめざし、子宮がん細胞株から幹細胞を選別しこれに対する特異抗原を同定し免疫療法へ応用への可能性を検討し、蛋白の一部が免疫療法に使うことが出来うることを証明した。
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Less correlation between mismatch repair proteins deficiency and decreased expression of HLA class I molecules in endometrial carcinoma: a different propensity from colorectal cancer.2020
Author(s)
Mariya T, Kubo T, Hirohashi Y, Yanagawa J, Tabuchi Y, Matsuo K, Furumura K, Morita R, Nakatsugawa M, Kanaseki T, Tsukahara T, Hasegawa T, Saito T, Torigoe T.
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Journal Title
Medical Molecular Morphology
Volume: 54
Issue: 1
Pages: 14-22
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma.2019
Author(s)
Tabuchi Y, Hirohashi Y, Hashimoto S, Mariya T, Asano T, Ikeo K, Kuroda T, Mizuuchi M, Murai A, Uno S, Kawai N, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Saito T, Torigoe T.
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Journal Title
Exp Mol Pathol
Volume: 106
Pages: 78-88
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer.2017
Author(s)
Shimada H, Abe S, Kohno K, Satohisa S, Konno T, Takahashi S, Hatakeyama T, Arimoto C, Kakuki T, Kaneko Y, Takano K, Saito T, Kojima T
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 10935-10935
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] ・The regulation of claudin-2 in endometriosis and endometrioid carcinoma cells2019
Author(s)
Seiro Satohisa, Hiroshi Shimada, Takayuki Kohno1), Takumi Konno1), Taishi Akimoto, Masahiro Iwasaki, Masato Tamate, Motoki Matsuura, Takashi Kojima1), Tsuyoshi Saito1
Organizer
ICC 2019 20th International Congress of Cytology（May.5-9, 2019, Sydney, Australia)
Related Report
Int'l Joint Research
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[Presentation] Local progression of endometrial cancer depends on microsatellite instability and HLA class I expression2018
Author(s)
T. Mariya, Y. Hirohashi1), J. Yanakawa1), T. Akimoto, M. Matsuura, S. Satohisa, M. Teramoto, M. Iwasaki, T. Kubo1), T. Torigoe1), T. Saito
Organizer
IGCS 17th Biennial Meeting of the International Gynecologic Cancer Society
Related Report
Int'l Joint Research
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