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Development of dental pulp regeneration therapy applying human dental pulp stem cells and fish collagen that has no potential for infectious diseases

Research Project

Project/Area Number 17K11806
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionNagasaki University

Principal Investigator

YAMAMOTO Kohei  長崎大学, 病院(歯学系), 医員 (20756407)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords魚由来コラーゲン / 歯髄幹細胞 / フィッシュコラーゲン / 歯髄再生 / 魚コラーゲン / メンブレン
Outline of Final Research Achievements

We have been studying the application of fish type I atelo collagen (FAC) as a scaffolding material, which has no possibility of zoonotic diseases. In this study, the safety and efficacy of fish-derived collagen as a scaffolding material were evaluated as a non-clinical study using canine teeth in combination with the FAC safety study.
The virus denial test was negative. The ISO standard tests for endotoxin level, cytotoxicity, sensitization, chromosomal abnormalities, intradermal irritation, acute systemic toxicity, febrile sensitivities, and hemolytic anemia were all within the standard values. Our findings on canine pulp regeneration using clinical grade FAC showed no rejection of the new pulp tissue.

Academic Significance and Societal Importance of the Research Achievements

人獣共通感染症への可能性のない魚由来タイプⅠコラーゲン(fish typeⅠatelo collagen:FAC )を足場材として応用するため検討を重ねてきた。臨床等級のFACを使用したイヌの歯髄再生に関する本所見では、新生した歯髄組織に拒絶反応は認めなかった。
これはFACの大動物への応用の安全性と有効性を証明した最初の報告であり足場材として哺乳類由来のコラーゲンの代替材料として有用であることを示唆した。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (1 results)

All 2020

All Presentation (1 results) (of which Invited: 1 results)

  • [Presentation] 架橋形抑制コラーゲンにおける魚由来コラーゲンペプチドのin vitro石灰化に及ぼす影響2020

    • Author(s)
      山田志津香,山本耕平
    • Organizer
      令和2年歯科保存学会春季学術大会(第153回)
    • Related Report
      2020 Annual Research Report
    • Invited

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Published: 2017-04-28   Modified: 2022-01-27  

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