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The relationship between autism spectrum disorder and neonatal jaundice

Research Project

Project/Area Number 17K16299
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionKobe University

Principal Investigator

Maeyama(Fujita) Kaori  神戸大学, 医学研究科, 医学研究員 (60767333)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsautism spectrum disorder / UGT1A1 / neonatal jaundice / developmental disorder / dried umbilical cord / 自閉スペクトラム症 / autism spectrum syndrome / 遺伝子 / 臨床
Outline of Final Research Achievements

To elucidate the role in the development of autism spectrum disorders (ASD), this study investigated the incidence of UDP-glucuronosyltransferase (UGT1A1) gene polymorphisms associated with neonatal jaundice in the population of ASD children and Japan. We compared it with the general frequency of humans and examined whether it was involved in the development of ASD.
As a result of analyzing the DNA, the frequency of UGT1A1*6 and UGT1A1*28 gene polymorphisms was the same as the general frequency of Japanese people, and at least the UGT1A1 gene polymorphism, which is one of the risks of developing neonatal jaundice in the onset of ASD was not considered to be involved.

Academic Significance and Societal Importance of the Research Achievements

本研究でASD発症におけるリスク因子としてUGT1A1遺伝子多型の有無が明らかになれば、新生児黄疸のなりやすさを評価することによって新生児黄疸の管理を適切に行うことが可能となり、ASDの発症予防につながることが期待できたが、UGT1A1遺伝子多型はASDの発症に関与していない事が明らかとなった。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (18 results)

All 2021 2020 2019 2018 2017

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (11 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children2021

    • Author(s)
      Horinouchi Tomoko、Maeyama Kaori、Nagai Masashi、Nishimura Mio、Kawasaki Yoko、Yoshioka Mieko、Takada Satoshi、Matsumoto Hisayuki、Nakamachi Yuji、Saegusa Jun、Fukushima Sachiyo、Fujioka Kazumichi、Nagase Hiroaki、Nozu Kandai、Iijima Kazumoto、Nishimura Noriyuki、他
    • Journal Title

      Journal of Autism and Developmental Disorders

      Volume: 1 Issue: 2 Pages: 1-1

    • DOI

      10.1007/s10803-021-04941-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 極低出生体重児と自閉スペクトラム症児の3歳時の発達特徴の比較2019

    • Author(s)
      万代ツルエ、前山花織 、岩谷壮太、藤岡一路、北山真次、飯島一誠、森岡一朗
    • Journal Title

      日本新生児成育医学会雑誌

      Volume: 31 Pages: 90-96

    • NAID

      40021851433

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 乳幼児期における発達障害特性と感覚特性との関連についての検討2018

    • Author(s)
      前山花織、高木康子、加藤威、溝渕雅巳、北山真次、高田哲、冨岡和美、永瀬裕朗、西村範行
    • Journal Title

      小児の精神と神経

      Volume: 58 Pages: 201-207

    • NAID

      40021699768

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis2018

    • Author(s)
      Maeyama K, Tomioka K, Nagase H, Yoshioka M, Takagi Y, Kato T, Mizobuchi M, Kitayama S, Takada S, Nagai M, Sakakibara N, Nishiyama M, Taniguchi-Ikeda M, Morioka I, Iijima K, Nishimura N
    • Journal Title

      Jornal of Autism Development Disorder

      Volume: 48 Pages: 1483-1491

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation index for asymmetric ventricular size on brain magnetic resonance images in very low birth weight infants2018

    • Author(s)
      Ikuta T, Mizobuchi M, Katayama Y, Yoshimoto S, Ioroi T, Yamane M, Morisawa T, Takatera A, Ueda M, Shibata A, Maeyama K, Mandai T, Fujioka K, Nishimura N, Iijima K, Morioka I.
    • Journal Title

      Brain Devopment

      Volume: 40 Pages: 753-759

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis2017

    • Author(s)
      Maeyama Kaori、Tomioka Kazumi、Nagase Hiroaki、Yoshioka Mieko、Takagi Yasuko、Kato Takeshi、Mizobuchi Masami、Kitayama Shinji、Takada Satoshi、Nagai Masashi、Sakakibara Nana、Nishiyama Masahiro、Taniguchi-Ikeda Mariko、Morioka Ichiro、Iijima Kazumoto、Nishimura Noriyuki
    • Journal Title

      Journal of Autism and Developmental Disorders

      Volume: 48 Issue: 5 Pages: 1483-1491

    • DOI

      10.1007/s10803-017-3412-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] NICU退院児における感覚特性,発達障害特性の検討2020

    • Author(s)
      村尾 真理子,前山 花織,万代 ツルエ,堀之内 智子、冨岡 和美,福嶋 祥代、阿部 真也、大山 正平、藤岡 一路、野津 寛大、飯島 一誠、高木 康子,加藤 威,岡田 由香、溝渕 雅巳,北山 真次,永瀬 裕朗,森岡 一朗,高田 哲、西村 範行
    • Organizer
      日本小児科学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 修正18~24ヶ月のNICU退院児における感覚特性の検討2019

    • Author(s)
      村尾 真理子,前山 花織,万代 ツルエ,高木 康子,加藤 威,岡田 由香、溝渕 雅巳,北山 真次,冨岡 和美,永瀬 裕朗,森岡 一朗,高田 哲、西村 範行
    • Organizer
      第121回日本小児精神神経学会
    • Related Report
      2019 Research-status Report
  • [Presentation] UGT1A1*6 and *28 as factors associated with prolonged hyperbilirubinemia in Japanese preterm infants2018

    • Author(s)
      Yamana K, Iwatani S, Fukushima S, Ikuta T, Ashina M, Ohyama S, Okubo S, Maeyama K, Fujioka K, Iijima K, Morioka I.
    • Organizer
      Pediatric Academic Society Annual Meeting,Toronto,Canada
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison between the incidence of short stature in term SGA and late-preterm AGA infants: A matched case-control study2018

    • Author(s)
      Fukushima S, Maeyama K,Mastumoto M,Ashina M, Ikuta T, Okubo S,Oyama S,Yamana K,Fujioka K, Awano H,Mishina H,Iijima K,Morioka I.
    • Organizer
      Pediatric Academic Society Annual Meeting,Toronto,Canada
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Is congenital cytomegalovirus infection associated with autism spectrum disorder?2018

    • Author(s)
      Nishimura N, Maeyama K, Tomioka K, Nagase H, Yoshioka M, Takagi Y, Kato T, Mizobuchi M, Kitayama S, Takada S, Nagai M, Sakakibara N, Nishiyama M, Morioka I, Iijima K
    • Organizer
      第60回日本小児神経学会
    • Related Report
      2018 Research-status Report
  • [Presentation] UGT1A1*28は早産児の晩期黄疸防止因子である2018

    • Author(s)
      山名啓司、岩谷壮太、福嶋祥代、生田寿彦、芦名満里子、大山正平、大久保沙紀、前山花織、藤岡一路、飯島一誠、森岡一朗
    • Organizer
      第121回日本小児科学会
    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Presentation] 神戸大学における小児科と麻酔科の連携による脊髄性筋萎縮症のヌシネルセン治療2018

    • Author(s)
      永井正志、粟野宏之、松本真明、坊 亮輔、冨岡和美、田中 司、西山将広、前山花織、永瀬裕朗、小幡典彦、溝渕知司、西尾久英、飯島一誠
    • Organizer
      第60回日本小児神経学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 乳幼児期における発達障害児の感覚特性についての検討 ~自閉症および知的障害特性との関連~2017

    • Author(s)
      前山花織、高木康子、吉岡三惠子、加藤威、溝渕雅巳、北山真次、高田哲、坊亮輔、冨岡和美、西山将広、粟野宏之、永瀬裕朗、飯島一誠、西村範行
    • Organizer
      第59回日本小児神経学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 乳幼児期における発達障害特性と感覚特性との関連についての検討2017

    • Author(s)
      前山花織、高木康子、加藤威、溝渕雅巳、北山真次、高田哲、冨岡和美、永瀬裕朗、飯島一誠、西村範行
    • Organizer
      第117回日本小児精神神経学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 乳幼児感覚プロファイルを用いた発達障害児の感覚特性に関する検討2017

    • Author(s)
      前山花織、高木康子、吉岡三惠子、加藤威、溝渕雅巳、北山真次、高田哲、松本真明、永井正志、坊亮輔、冨岡和美、西山将広、粟野宏之、永瀬裕朗、飯島一誠、西村範行
    • Organizer
      第270回 日本小児科学会兵庫県地方会 尼崎
    • Related Report
      2017 Research-status Report
  • [Presentation] 早産児における晩期黄疸リスク因子2017

    • Author(s)
      山名啓司、岩谷壮太、福嶋祥代、生田寿彦、芦名満理子、大山正平、大久保沙紀、前山花織、藤岡一路、飯島一誠、森岡一朗
    • Organizer
      第62回日本新生児成育医学会
    • Related Report
      2017 Research-status Report
  • [Book] 胎児発育不全2018

    • Author(s)
      前山花織、森岡一朗
    • Total Pages
      196
    • Publisher
      中外医学社
    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2023-01-30  

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