Molecular targeting for scirrhous gastric cancer

• Project/Area Number: 18390369
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Osaka City University
• Principal Investigator: HIRAKAWA Kosei Osaka City University, 大学院・医学研究科, 教授 (40188652)
• Co-Investigator(Kenkyū-buntansha): YASHIRO Masakazu 大阪市立大学, 大学院・医学研究科, 准教授 (60305638)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥7,430,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,230,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
• Keywords: スキルス胃癌 / 分子標的治療 / FGFR阻害剤 / 抗癌剤 / トランスレーショナルリサーチ / スキルス骨癌 / 癌 / 胃癌腹膜転移 / COX-2阻害剤 / HGF / シグナル抑制

Research Abstract

Scirrhous gastric carcinoma is characterized by rapid cancer cell infiltration and proliferation accompanied by extensive stromal fibrosis. Scirrhous carcinomas carry a worse prognosis than other types of gastric carcinoma. Keratinocyte growth factor (KGF) ; a ligand of FGF-R2, produced by gastric fibroblasts is likely to contribute in a paracrine manner to the remarkable cell proliferation seen in scirrhous gastric cancer with FGF-R2 amplification. Also, COX2 signal from stromal fibroblasts stimulates the invasion ability of scirrhous gastric cancer cells. The FGF-R2 phosphorylation inhibitor or COX2 inhibitor appear therapeutically promising in scirrhous gastric carcinoma.

Research Products

• [Journal Article] Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model. (2009)
  • Author(s): Yashiro, M., Shinto, O., Nakamura, K., Tendo, M., Matsuoka, T., Matsuzaki, T., Kaizaki, R., Ohira, M., Miwa, A., Hirakawa, K
  • Journal Title: Br J Cancer 101 Pages: 1100-1106
  • Peer Reviewed
• [Journal Article] Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling. (2009)
  • Author(s): Komuro, A., Yashiro, M.., Iwata, C., Morishita, Y., Johansson, E., Matsumoto, Y., Watanabe, A., Aburatani, H., Miyoshi, H., Kiyono, K., Shirai, Y.T., Suzuki, H.I., Hirakawa, K.., Kano, M.R., Miyazono, K
  • Journal Title: J Natl Cancer Inst 101 Pages: 592-604
  • Peer Reviewed
• [Journal Article] Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells. (2009)
  • Author(s): Yashiro, M., Yasuda, K., Nishii, T., Kaizaki, R., Sawada, T., Ohira, M., Hirakawa, K.
  • Journal Title: Int J Oncol 35 Pages: 997-1003
  • Peer Reviewed
• [Journal Article] Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on scirrhous gastric carcinoma. (2009)
  • Author(s): Yashiro, M.., Shinto, O., Nakamura, K., Tendo, M., Matsuoka, T., Matsuzaki, T., Kaizaki, R., Miwa, A., Hirakawa, K.
  • Journal Title: Int J Cancer
  • Peer Reviewed
• [Journal Article] Allelic imbalance at p53 and microsatellite instability are predictive markers for resistance to chemotherapy in gastric carcinoma. (2009)
  • Author(s): Yashiro, M.., Inoue, T., Nishioka, N., Matsuoka, T., Bol, C.R., Hirakawa, K.
  • Journal Title: Ann Surg Oncol 16 Pages: 2926-2935
  • Peer Reviewed
• [Journal Article] Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma. (2009)
  • Author(s): Toyokawa, T., Yashiro, M., Hirakawa, K.
  • Journal Title: Oncol Rep 21 Pages: 875-880
  • Peer Reviewed
• [Journal Article] Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells. (2009)
  • Author(s): Semba, S., Kodama, Y., Ohnuma, K., Mizuuchi, E., Masuda, R., Yashiro, M.., Hirakawa, K., Yokozaki, H.
  • Journal Title: Br J Cancer
  • Peer Reviewed
• [Journal Article] Synergistic antiproliferative effect of mTOR inhibitors in combination with 5-fluorouracil in scirrhous gastric cancer. (2009)
  • Author(s): Matsuzaki, T., Yashiro, M.., Kaizaki, R., Yasuda, K., Doi, Y., Sawada, T., Ohira, M., Hirakawa, K.
  • Journal Title: Cancer Sci
  • NAID: 10027198595
  • Peer Reviewed
• [Journal Article] Expression of ERas oncogene in gastric carcinoma. (2009)
  • Author(s): Kaizaki, R., Yashiro, M.., Shinto, O., Yasuda, K., Hirakawa, K.
  • Journal Title: Anticancer Res 29 Pages: 2189-2193
  • Peer Reviewed
• [Journal Article] Effects of VEGFR-3 phosphorylation inhibitor on lymph node met astasis in an orthotopic diffuse-type gastric carcinoma model. (2009)
  • Author(s): Yashiro M, Shinto O, Hirakawa K.
  • Journal Title: British journal of cancer 101 Pages: 1100-1106
  • Peer Reviewed
• [Journal Article] Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells (2009)
  • Author(s): Yashiro M, Yasuda K, Hirakawa K
  • Journal Title: International journal of oncology 35 Pages: 997-1003
  • Peer Reviewed
• [Journal Article] Allelic Imbalance at p53 and Microsatellite Instability Are Predictive Markers for Resistance to Chemotherapy in Gastric Carcinoma (2009)
  • Author(s): Yashiro M, Inoue T, Hirakawa K
  • Journal Title: Annals of surgical oncology 16 Pages: 2926-2935
  • Peer Reviewed
• [Journal Article] Diffuse-type gastric carcinoma : progression, angiogenesis, and transforming growth factor beta signaling (2009)
  • Author(s): Komuro A, Yashiro M, Iwata C, Morishita Y, Johansson E, Matsumoto Y, Watanabe Aburatani H, Miyoshi H, Kiyono K, Shirai YT, Suzuki HI, Hirakawa K, Kano MR, Miyazono K.
  • Journal Title: J Natl Cancer Inst 15 ; 101 Pages: 592-604
• [Journal Article] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. (2008)
  • Author(s): Kunii K, Davis L, Gorenstein J, Hatch H, Yashiro M, Di Bacco A, Elbi C, Lutterbach B.
  • Journal Title: Cancer Res 68(7) Pages: 2340-2348
  • Peer Reviewed
• [Journal Article] A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma. (2008)
  • Author(s): Kawajiri, H., Yashiro, M., Shinto, O., Nakamura, K., Tendo, M., Takemura, S, Node, M., Hamashima, Y., Kajimoto, T., Sawada, T., Ohira, M., Hirakawa, K.
  • Journal Title: Clin Cancer Res 14 Pages: 2850-2860
  • Peer Reviewed
• [Journal Article] Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway. (2008)
  • Author(s): Fujiwara, I., Yashiro, M.., Kubo, N., Maeda, K., Hirakawa, K.
  • Journal Title: Dis Colon Rectum 51 Pages: 1387-1394
  • Peer Reviewed
• [Journal Article] A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma. (2008)
  • Author(s): Kawajiri H, Yashiro M, Shinto O, Nakamura K, Tendo M, Takemura S, Node M, Hamashima Y, Kajimoto T, Sawada T, Ohira M, Hirakawa K.
  • Journal Title: Clinical Cancer Research 14 Pages: 2850-60
• [Journal Article] A Novel Transforming Growth Factor beta Receptor Kinase Inhibitor, A-77, Prevents the Peritoneal Dissemination of Scirrhous Gastric Carcinoma. (2008)
  • Author(s): Kawajiri H, Yashiro M, Hirakawa K.
  • Journal Title: Clin Cancer Res 14 Pages: 2850-2860
  • Peer Reviewed
• [Journal Article] Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma. (2007)
  • Author(s): Yashiro, M.., Nakazawa, K., Tendo, M., Kosaka, K., Shinto, O., Hirakawa, K.
  • Journal Title: Int J Cance 120 Pages: 686-693
  • Peer Reviewed
• [Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling. (2007)
  • Author(s): Kano, M.R., Bae, Y., Iwata, C., Morishita, Y., Yashiro, M.., Oka, M., Fujii, T., Komuro, A., Kiyono, K., Kaminishi, M., Hirakawa, K.., Ouchi, Y., Nishiyama, N., Kataoka, K., Miyazono, K.
  • Journal Title: Proc Natl Acad Sci U S A 104 Pages: 3460-3465
  • Peer Reviewed
• [Journal Article] Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis. (2007)
  • Author(s): Iwata, C., Kano, M.R., Komuro, A., Oka, M., Kiyono, K., Johansson, E., Morishita, Y., Yashiro, M.., Hirakawa, K.., Kaminishi, M., Miyazono, K.
  • Journal Title: Cancer Res 67 Pages: 10181-10189
  • Peer Reviewed
• [Journal Article] Prognostic impact of PCR-based identification of isolated tumour cells in the peritoneal lavage fluid of gastric cancer patients who underwent a curative R0 resection. (2007)
  • Author(s): Katsuragi, K., Yashiro, M.., Sawada, T., Osaka, H., Ohira, M., Hirakawa, K.
  • Journal Title: Br J Cancer 97 Pages: 550-556
  • Peer Reviewed
• [Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling (2007)
  • Author(s): Kano MR, Bae Y, Iwata C, Morishita Y, Yashiro M, Oka M, Fujii T, Komuro A, Kiyono K, Kaminishi M, Hirakawa K, Ouchi Y, Nishiyama N, Kataoka K and Miyazono K.
  • Journal Title: Proc. Natl. Acad. Sci. USA 104 Pages: 3460-3465
• [Journal Article] Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma (2007)
  • Author(s): Yashiro M, Nakazawa K, Tendo M, Kosaka K, Shinto O, Hirakawa K
  • Journal Title: Int J Cancer 120 Pages: 686-693
• [Journal Article] Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithehial-mesenchymal interactions of growth in scirrhous gastric carcinoma. (2007)
  • Author(s): Yashiro M, Hirakawa, K.
  • Journal Title: International Journal of Cancer 120 Pages: 686-693
  • Peer Reviewed
• [Journal Article] A novel angiogenesis inhibitor,Ki23057,is useful for preventing the progression of colon cancer and the spreading of cancer cells to the liver. (2007)
  • Author(s): Sakurai K, Yashiro M, Hirakawa K.
  • Journal Title: European Journal of Cancer 43 Pages: 2612-2620
  • Peer Reviewed
• [Journal Article] FGF-R2/K-samllを分子標的としたスキルス胃癌の新規治療法 (2007)
  • Author(s): 八代 正和, 平川 弘聖
  • Journal Title: 消化器科 44 Pages: 447-454
• [Journal Article] Decreased expression of the adhesion molecule desmoglein-2 is associated with diffuse-type gastric carcinoma. (2006)
  • Author(s): Yashiro, M.., Nishioka, N., Hirakawa, K.
  • Journal Title: Eur J Cancer 42 Pages: 2397-2403
  • Peer Reviewed
• [Journal Article] A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells. (2006)
  • Author(s): Tendo, M., Yashiro, M.., Nakazawa, K., Yamada, N., Sawada, T., Ohira, M., Hirakawa, K.
  • Journal Title: Cancer Lett 244 Pages: 247-251
  • Peer Reviewed
• [Journal Article] A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer. (2006)
  • Author(s): Nakamura, K., Yashiro, M.., Matsuoka, T., Tendo, M., Shimizu, T., Miwa, A., Hirakawa, K.
  • Journal Title: Gastroenterology 131 Pages: 1530-1541
  • Peer Reviewed
• [Journal Article] Simultaneous bilateral laparoscopic adrenalectomy for adrenocorticotropic hormone-independent macronodular adrenal hyerplasia: report of a case. (2006)
  • Author(s): Kubo, N., Onoda, N., Ishikawa, T., Ogawa, Y., Takashima, T., Yamashita, Y., Tahara, H., Inaba, M., Hirakawa, K.
  • Journal Title: Surg Today 36 Pages: 642-646
  • NAID: 10017614290
  • Peer Reviewed
• [Journal Article] Antitumor effect of trastuzumab for pancreatic cancer with high HER-2 expression and enhancement of effect by combined therapy with gemcitabine. (2006)
  • Author(s): Kimura, K., Sawada, T., Komatsu, M., Inoue, M., Muguruma, K., Nishihara, T., Yamashita, Y., Yamada, N., Ohira, M., Hirakawa, K.
  • Journal Title: Clin Cancer Res 12 Pages: 4925-4932
  • Peer Reviewed
• [Journal Article] A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer (2006)
  • Author(s): Nakamura K, Yashiro M, Matsuoka T, Tendo M, Shimizu T, Miwa A, Hirakawa K.
  • Journal Title: Gastroenterology 131 Pages: 1530-1541
• [Journal Article] A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer. (2006)
  • Author(s): Nakamura, K., Yashiro, M., Matsuoka, T., Tendo, M., Shimizu, T., Miwa, A., Hirakawa, K
  • Journal Title: Gastroenterology 131 Pages: 1530-1541
• [Journal Article] スキルス胃癌における縁組化は癌の進展にどのようにかかわるのか? (2006)
  • Author(s): 八代正和, 井上透, 深田鉄二, 大平雅一, 平川弘聖
  • Journal Title: 分子消化器病 3巻3号 Pages: 245-250
• [Presentation] A novel transforming growth factor β receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma (2009)
  • Author(s): Masakazu Yashiro, Hirakawa K
  • Organizer: 100^<th> AACR meeting
  • Place of Presentation: Denver, CO, USA
  • Year and Date: 2009-04-20
• [Presentation] A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma (2009)
  • Author(s): Yashiro M, Kawajiri H, Shinto O, Nakamura K, Tendo M, Takemura S, Node M, Hamashima Y, Kajimoto T, Sawada T, Ohira M, Hirakawa K.
  • Organizer: 100th American Association for Cancer Research
  • Place of Presentation: Denver
  • Year and Date: 2009-04-19
• [Presentation] A Novel Molecular Targeting Compound as K-samII/FGFR2 Phosphorylation Inhibitor, Ki23057, for Scirrhous Gastric Cancer (2008)
  • Author(s): Yashiro, M, Nakamura, K, Matsuoka, T, Tendo, M, Shimizu, T, Miwa, A, Hirakawa K.
  • Organizer: 99th American Association for Cancer Research
  • Place of Presentation: San Diego
  • Year and Date: 2008-04-20
• [Presentation] A Novel Molecular Targeting Compound as K-samII/FGFR2 Phosphorylation Inhibitor, Ki23057, for Scirrhous Gastric Cancer (2008)
  • Author(s): Yashiro, M., Nakamura, K., Matsuoka, T., Tendo, M., Shimizu, T., Miwa, A., Hirakawa, K.
  • Organizer: 102th American Association for Cancer Research
  • Place of Presentation: San Diego
  • Year and Date: 2008-04-14
• [Presentation] A novel molecular targeting compound as FGF-R2 phosphorylation inhibitor, Ki23057, for scirrhous gastric cancer. (2008)
  • Author(s): Yashiro M, Hirakawa, K.
  • Organizer: AACR
  • Place of Presentation: San Diego(USA)
  • Year and Date: 2008-04-14
• [Presentation] スキルス胃癌進展における病態と分子標的治療 (2007)
  • Author(s): 八代正和、中村和憲、豊川貴弘、井上透、山田靖哉、山下好人、前田清、小野田尚佳、澤田鉄二、仲田文造、加藤保之、大平雅一、石川哲郎、三輪篤史、平川弘聖
  • Organizer: 第18回日本消化器癌発生学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2007-11-09
• [Presentation] スキルス胃癌の分子標的治療 (2007)
  • Author(s): 八代正和、中村和憲、川尻成美、神藤理、豊川貴弘、宮園浩平、野出学、梶本哲也、三輪篤史、平川弘聖
  • Organizer: 第45回日本癌治療学会総会
  • Place of Presentation: 京都
  • Year and Date: 2007-10-26
• [Presentation] FGF-R2/K-samIIおよびTGF-βreceptorを分子標的としたスキルス胃癌転移の治療 (2007)
  • Author(s): 八代正和、川尻成美、神藤理、中村和憲、豊川貴弘、宮園浩平、野出学、梶本哲也、三輪篤史、平川弘聖
  • Organizer: 第62回日本消化器外科学会定期学術総会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-18
• [Presentation] Selective cyclooxygenase-2 inhibitor down-regulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma (2007)
  • Author(s): Yashiro M, Nakazawa, K, Tendo, M, Kosaka, K, Shinto, O, Hirakawa, K.
  • Organizer: 98th American Association for Cancer Research
  • Place of Presentation: Los Angels
  • Year and Date: 2007-04-19
• [Presentation] Selective cyclooxygenase-2 inhibitor down-regulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma (2007)
  • Author(s): Yashiro M, Nakazawa, K., Tendo, M., Kosaka, K., Shinto, O., Hirakawa, K.
  • Organizer: 101th American Association for Cancer Research
  • Place of Presentation: Los Angels
  • Year and Date: 2007-04-16
• [Presentation] Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma. (2007)
  • Author(s): Yashiro M, Hirakawa, K.
  • Organizer: AACR
  • Place of Presentation: Los Angels(USA)
  • Year and Date: 2007-04-15
• [Presentation] Anti-tumor Effect of Fibroblast Growth Factor Receptor type2(FGF-R2)Inhibitor On Gastric Cancer Cells (2007)
  • Author(s): MYashiro, OShinto, TNishii, KNakamura, TInoue, A,Miwa, Khirakawa
  • Organizer: New targets and delivery systems for cancer diagnosis and treatment
  • Place of Presentation: San Diego
  • Year and Date: 2007-03-10
• [Presentation] Anti-tumor Effect of Fibroblast Growth Factor Receptor type2 (FGF-R2)Inhibitor On Gastric Cancer Cells (2007)
  • Author(s): M. Yashiro, O. Shinto, T. Nishii, K. Nakamura, T. Inoue, A, Miwa, K. Hirakawa
  • Organizer: NEW TARGETS AND DELIVERY SYSTEMS FOR CANCER DIAGNOSIS AND TREATMENT
  • Place of Presentation: San Diego
  • Year and Date: 2007-03-06
• [Presentation] スキルス胃癌の分子標的治療 (2007)
  • Author(s): 八代正和、川尻成美、神藤理、井上透、西口幸雄、加藤保之、宮園浩平、野出学、榎本哲也、三輪篤史、平川弘聖
  • Organizer: 第79回日本胃癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-03-02
• [Presentation] Fibroblast growth factor receptor2/K-samIIを分子標的としたスキルス胃癌の治療 (2006)
  • Author(s): 八代正和、中村和憲、平川弘聖
  • Organizer: 第48回日本消化器病学会大会
  • Place of Presentation: 札幌
  • Year and Date: 2006-10-11
• [Presentation] TGFβレセプター阻害剤と抗腫瘍剤(S-1)の併用によるスキルス胃癌の新規治療法 (2006)
  • Author(s): 八代正和、川尻成美、平川弘聖
  • Organizer: 第48回日本消化器病学会大会
  • Place of Presentation: 札幌
  • Year and Date: 2006-10-11
• [Presentation] DYSPLASIA-COLITIC CANCER SEQUENCE IN ULCERATIVE COLITIS IS FREQUENTLY ASSOCIATED WITH MICROSATELLITE INSTABILITY PATHWAY. (2006)
  • Author(s): M. Yashiro, I. Fujiwara, N Kubo, K. Maeda, K. Hirakawa
  • Organizer: 12th International Conference on Ulcer Research (ICUR)
  • Place of Presentation: Osaka
  • Year and Date: 2006-07-08
• [Presentation] スキルス胃癌の病態と分子標的治 (2006)
  • Author(s): 八代正和、中村和憲、井上透、山田靖哉、西口幸雄、澤田鉄二、大平雅一、前田清、加藤保之、石川哲郎、平川弘聖
  • Organizer: 第78回日本胃癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2006-03-11
• [Book] スキルス胃癌ー基礎と臨床ー(曽和融生、井藤久雄編) (2010)
  • Author(s): 平川弘聖、八代正和
  • Publisher: 医薬ジャーナル社
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/surgical-oncology/
• [Patent(Industrial Property Rights)] プライマー、腫瘍マーカー、及び癌の検出方法 (2007)
  • Inventor(s): 八代正和, 平川弘聖, 澤田鉄二
  • Industrial Property Rights Holder: 財団法人大阪産業振興機構、八代正和,平川弘聖,澤田鉄二
  • Filing Date: 2007-05-15
• [Patent(Industrial Property Rights)] TGF-βシグナル阻害剤と抗腫瘍剤の組み合せ使用 (2007)
  • Inventor(s): 片岡一則, 宮園浩平, 狩野光伸, 平川弘聖, 八代正和, 野出學, Bae Younsoo, 西山伸宏
  • Industrial Property Rights Holder: 科学技術振興機構
  • Industrial Property Number: 2006-024843
  • Filing Date: 2007
• [Patent(Industrial Property Rights)] tgf-βシグナル阻害剤と抗腫瘍剤の組み合せ使用 (2006)
  • Inventor(s): 片岡一則(東京大学), 宮園浩平(東京大学), 狩野光伸(東京大学), 平川弘聖(大阪市立大学), 八代正和(大阪市立大学), 野出學(京都薬科大学), Bae Younsoo(東京大学), 西山伸宏(東京大学)
  • Industrial Property Rights Holder: 科学技術振興機構
  • Industrial Property Number: 2006-024843
  • Filing Date: 2006-08-30
• [Patent(Industrial Property Rights)] プライマー、腫瘍マーカー、及び癌の検出方法 (2006)
  • Inventor(s): 八代正和, 平川弘聖, 澤田鉄二
  • Industrial Property Rights Holder: 財団法人大阪産業振興機構
  • Filing Date: 2006