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Investigation of physiology, ecology, and constituents in the invertebrates, which inhabit in the coral reef of the North Pacific

Research Project

Project/Area Number 18406002
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Living organism molecular science
Research InstitutionChiba University (2008)
Kanazawa University (2006-2007)

Principal Investigator

TSUKAMOTO Sachiko  Chiba University, 大学院・理学研究科, 教授 (40192190)

Co-Investigator(Kenkyū-buntansha) NAMIKOSHI Michio  東北薬科大学, 薬学部, 教授 (30189196)
Co-Investigator(Renkei-kenkyūsha) NAMIKOSHI Michio  東北薬科大学, 薬学部, 教授 (30189196)
UKAI Kazuyo  東北薬科大学, 薬学部, 助教 (60433512)
KOBAYASHI Hisayoshi  東京大学, 分子細胞生物学研究所, 助教 (80225531)
Research Collaborator MANGINDAAN Remy E. P  インドネシア, サムラトランギ大学, 教授
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥15,360,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2006: ¥6,000,000 (Direct Cost: ¥6,000,000)
Keywords調査研究 / 海洋無脊椎動物 / 熱帯サンゴ礁 / 生理 / 生態 / 化学成分 / インドネシア / 北スラウエシ州 / 海洋無脊椎生物 / 海綿 / ホヤ / 細胞毒性 / スクリーニング / 真菌 / 北スラクエシ州 / イミダゾールアルカロイド
Research Abstract

本研究課題は、熱帯サンゴ礁に棲息する海洋生物の生理・生態と化学成分について調査することが目的である.これまでの研究により、海綿から、細胞増殖阻害活性を示す新規化合物、がん抑制遺伝子産物p53 の作用を増強することが期待される化合物、および、プロテアソームの作用を阻害する化合物などを発見することができた.今後、さらに生物活性物質の探索を続ける予定である.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (25 results)

All 2009 2008 2007 2006 Other

All Journal Article (13 results) (of which Peer Reviewed: 8 results) Presentation (11 results) Remarks (1 results)

  • [Journal Article] Absolute Configuration of the α,ω-Bifunctionalized Sphingolipid Leucettamol A from Leucetta sp2009

    • Author(s)
      D. S. Dailisay, S. Tsukamoto, and T. F. Molinski
    • Journal Title

      by Deconvoluted Exciton Coupled CD. J. Nat. Prod 72(3)

      Pages: 353-359

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of Antipodal (-)-Versicolamide B and Notoamides L-N from a Marine-derived Aspergillus SD.2009

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Org. Lett. 11

      Pages: 1297-1300

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of Notoamide E, a Key Precursor in the Biosynthesis of Prenylated Indole Alkaloids in a Marine-derived Fungus, Aspergillus sp.2009

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      J. Am. Chem. Soc. 131

      Pages: 3834-3835

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absolute Configuration of the am-Bifunctionalized Sphingolipid Leucettamol A from Leucetta so. by Deconvoluted Exciton Coupled CD2009

    • Author(s)
      D. S. Dailisay
    • Journal Title

      J. Nat. Prod. 72

      Pages: 353-359

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leucettamol A : A New Inhibitor of Ubc13-Uev1A Interaction Isolated from a Marine Sponge, Leucetta aff2008

    • Author(s)
      S. Tsukamoto, T. Takeuchi, H. Rotinsulu, R. E. P. Mangindaan, R. W. M. van Soest ,K. Ukai, H. Kobayashi, M. Namikoshi, T. Ohta, and H. Yokosawa
    • Journal Title

      microrhaphis, Bioorg. Med. Chem. Lett 18(24)

      Pages: 6319-6320

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leucettamol A: A New Inhibitor of Ubc13-UevlA Interaction Isolated from a Marine Sponge, Leucetta aff. Microrhaphis2008

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 6319-6320

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Naamidines H and I : Cytotoxic Imidazole Alkaloids from the Indonesian Marine Sponge, Leucetta chagosensis2007

    • Author(s)
      S. Tsukamoto, T. Kawabata, H. Kato, T. Ohta, H. Rotinsulu, R. E. P. Mangindaan, R. W. M. van Soest, K. Ukai, H. Kobayashi and M. Namikoshi
    • Journal Title

      J. Nat. Prod 70(10)

      Pages: 1658-1660

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Naamidines H and I: Cytotoxic Imidazole Alkaloids from the Indonesian Marine Sponge, Leucttta chagosensis2007

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      J. Nat. Prod 70

      Pages: 1658-1660

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hexylitaconic acid : a new inhibitor of p53-HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp.2006

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Bioorg. Med. Chem. Lett. 16(1)

      Pages: 69-71

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of Emetine, a Protein Synthesis Inhibitor, on Larval Tail Resorption in the Ascidian Halocynthia roretzi.2006

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Sessile Organisms 23(2)

      Pages: 43-46

    • NAID

      10018254289

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neurotrophic Sesterterpenes Isolated from a Marine Sponge, Spongia sp.2006

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Heterocycles 69(1)

      Pages: 521-526

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Natural Products Inhibiting the Ubiquitin-proteasome Proteolytic Pathway, a Target for Drug Development2006

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Curr. Med. Chem. 13(7)

      Pages: 745-754

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The Search for Inhibitors of the Ubiquitin-proteasome System from Natural Resources for Drug Development2006

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      J. Nat. Med. 60(4)

      Pages: 273-278

    • NAID

      10020623848

    • Related Report
      2006 Annual Research Report
  • [Presentation] ニシキボヤホヤ由来アルカロイドN, N-didesmethylgrossularine-1 のヒト炎症性サイトカイン産生阻害効果2009

    • Author(s)
      浪越通夫
    • Organizer
      日本薬学会第129回年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 海綿Aaptos aaptosから得られたプロテアソーム阻害物質2009

    • Author(s)
      塚本佐知子
    • Organizer
      日本薬学会第129回年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 海洋由来糸状菌から得られた新規ノトアミド類の構造と生合成研究2008

    • Author(s)
      塚本佐知子
    • Organizer
      第50回天然有機化合物討論会
    • Place of Presentation
      福岡
    • Year and Date
      2008-09-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ユビキチンープロテアソームシステムを阻害する1eucettamol Aとその誘導体の活性について2008

    • Author(s)
      塚本佐知子
    • Organizer
      第12回がん分子標的治療研究会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] ユビキチンシステムを標的とする天然からの創薬リード化合物の探索2008

    • Author(s)
      塚本 佐知子
    • Organizer
      日本薬学会第128年会(シンポジウム)
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] インドネシア産海綿Leucetta microrhaphisから得られたプロテアソーム阻害物質2008

    • Author(s)
      塚本佐知子
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] インドネシア産海綿Leucetta microrhaphisから得られたプロテアソーム阻害物質2008

    • Author(s)
      塚本 佐知子
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Search for natural products inhibiting the Ubc13 ubiquitin E2 enzyme-Uev1A complex formation2008

    • Author(s)
      Sachiko Tsukamoto
    • Organizer
      Gordon Research Conference(Marine Natural Products) (招待講演)
    • Place of Presentation
      Ventura(CA,USA)
    • Year and Date
      2008-02-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] ユビキチン-プロテアソームシステムを阻害するleucettamol A とその誘導体の活性について2008

    • Author(s)
      塚本佐知子
    • Organizer
      第12回がん分子標的治療研究会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 群体ボヤLissoclinum cf. adium から単離した新規Lissoclibadin類2007

    • Author(s)
      王偉芳
    • Organizer
      第49回天然有機化合物討論会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] インドネシア産海綿から得られた新規イミダゾールアルカロイドの構造2007

    • Author(s)
      塚本佐知子
    • Organizer
      日本薬学会第127回年会
    • Place of Presentation
      富山
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://web.mac.com/stsuka

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2019-04-12  

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