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Post longitudinal extension of spinal cord injury in spinal and section and contusion

Research Project

Project/Area Number 18591625
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKanazawa University

Principal Investigator

TOMITA Katsuro  Kanazawa University, Graduate School of Medical Science, Professor (00092792)

Co-Investigator(Kenkyū-buntansha) KAWAHARA Norio  Kanazawa University, University Hospital, Assistant Professor (70214674)
MURAKAMI Hideki  Kanazawa University, University Hospital, Assistant Professor (70334779)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsspinal cord injury / spinal cord section / spine tumor / 腫瘍脊髄骨全摘術 / 脊髄腫瘍
Research Abstract

The present study evaluated post longitudinal extension of spinal cord injury in spinal cord section and contusion.
Six dogs were used for the experiments of the acute phase and divided into two groups ; spinal cord section and spinal cord contusion. Spinal cord evoked potentials (SCEP) and Motor evoked potentials (MEP) were measured immediately after spinal cord oration and contusion. In the spinal cord section, the amplitudes of the SCEP decreased 2cm above section immediately after spinal cord section. In the spinal cord contusion, the amplitudes of the SCEP decreased 2 cm above contusion immediately attar spinal cord contusion.
Six dogs were used for the experiments of the chronic phase and divided into two groups ; spinal and section and spinal cord contusion. SCEP and MEP were measured one week after spinal cord section and contusion. In the spinal cord section, the amplitudes of the SCEP decreased 3.5≠±0.3 cm above section one week after spinal cord oration. In the spinal cord contusion, the amplitudes of the SCEP decreased 25±0.5cm above contusion one week after spinal cord contusion.
Histology and microscopy of the dogs one week after spinal cord section and contusion were evaluated. In the spinal cord section, white and gray matter damage was seen 2-4 cm above spinal cord section. In the spinal cord contusion, a "tooth paste phenomenon" was recognized pathologically. This is a phenomenon that occurs when parenchymal tissue of spinal cord is squeezed and penetrates above and below the level of compression. Gray matter damage was seen 2-4 cm above spinal cord contusion. We considered that spinal cord section compressed spinal cord like spinal contusion
Because such a tooth paste phenomenon occurs when a spinal cord is ligated, transaction with a scalpel, instead of ligation, is desirable to avoid damaging spinal cord. The present study suggests that secondary spinal cord injury occurs several days after spinal cord injury.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (9 results)

All 2007 2006

All Journal Article (7 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Invasive features of spinal osteosarcoma obtained from whole-mount sections of total en bloc spondylectomy2007

    • Author(s)
      Murakami H, Kawahara N, Tsuchiya H, Demura S, Yamaguchi T, Tomita K
    • Journal Title

      Journal of Orthopaedic Science 12(3)

      Pages: 311-315

    • NAID

      10019488737

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Invasive features of spinal osteosarcoma obtained from whole-mount sections of total en bloc spondylectomy2007

    • Author(s)
      Murakami, H., Kawahara, N., Tsuchiya, H., Demura, S., Yamaguchi, T., Tomita, K
    • Journal Title

      Journal of Orthopaedic Science 12(3)

      Pages: 311-315

    • NAID

      10019488737

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Invasive features of spinal osteosarcoma obtained from whole-mount sections of total en bloc spondylectomy2007

    • Author(s)
      Murakami H, Kawahara N, Tsuchiya H, Demura S, Yamaguchi T, Tomita K
    • Journal Title

      J Orthop Sci (in press)

    • NAID

      10019488737

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Complete segmental resection of the spine, Including the spinal cord, for telangiectatic osteosarcoma: a report of 2 cases2006

    • Author(s)
      Murakami H, Tomita K, Kawahara N, Oda M, Yahata T, Yamaguchi T
    • Journal Title

      Spine 31(4)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Complete segmental resection of the spine, Including the spinal cord, for telangiectatic osteosarcoma : a report of 2 cases2006

    • Author(s)
      Murakami, H., Tomita, K., Kawahara, N., Oda, M., Yahata, T., Yamaguchi, T
    • Journal Title

      Spine 31(4)

      Pages: 117-122

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Complete segmental resection of the spine including the spinal cord for telangiectatic osteosarcoma2006

    • Author(s)
      Murakami H, Tomita K, Kawahara N, Oda M, Yahata T, Yamaguchi T
    • Journal Title

      Spine 31

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 脊椎骨肉腫の"en bloc"切除標本から得た新知見-病理から手術へのフィードバック2006

    • Author(s)
      村上英樹, 富田勝郎, 川原範夫, 土屋弘行, 山口岳彦
    • Journal Title

      臨床整形外科 41

      Pages: 183-189

    • Related Report
      2006 Annual Research Report
  • [Presentation] "en bloc"脊椎骨肉腫切除標本から得た新知見の手術へのフィードバック2006

    • Author(s)
      村上英樹
    • Organizer
      日本整形外科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2006-05-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Invasive features of spinal osteosarcoma obtained from whole-mount sections of total en bloc spondylectomy2006

    • Author(s)
      Murakami, H
    • Organizer
      Japan Orthopaedic Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-05-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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