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2007 Fiscal Year Final Research Report Summary

Post longitudinal extension of spinal cord injury in spinal and section and contusion

Research Project

Project/Area Number 18591625
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKanazawa University

Principal Investigator

TOMITA Katsuro  Kanazawa University, Graduate School of Medical Science, Professor (00092792)

Co-Investigator(Kenkyū-buntansha) KAWAHARA Norio  Kanazawa University, University Hospital, Assistant Professor (70214674)
MURAKAMI Hideki  Kanazawa University, University Hospital, Assistant Professor (70334779)
Project Period (FY) 2006 – 2007
Keywordsspinal cord injury / spinal cord section / spine tumor
Research Abstract

The present study evaluated post longitudinal extension of spinal cord injury in spinal cord section and contusion.
Six dogs were used for the experiments of the acute phase and divided into two groups ; spinal cord section and spinal cord contusion. Spinal cord evoked potentials (SCEP) and Motor evoked potentials (MEP) were measured immediately after spinal cord oration and contusion. In the spinal cord section, the amplitudes of the SCEP decreased 2cm above section immediately after spinal cord section. In the spinal cord contusion, the amplitudes of the SCEP decreased 2 cm above contusion immediately attar spinal cord contusion.
Six dogs were used for the experiments of the chronic phase and divided into two groups ; spinal and section and spinal cord contusion. SCEP and MEP were measured one week after spinal cord section and contusion. In the spinal cord section, the amplitudes of the SCEP decreased 3.5≠±0.3 cm above section one week after spinal cord oration. In the spinal cord contusion, the amplitudes of the SCEP decreased 25±0.5cm above contusion one week after spinal cord contusion.
Histology and microscopy of the dogs one week after spinal cord section and contusion were evaluated. In the spinal cord section, white and gray matter damage was seen 2-4 cm above spinal cord section. In the spinal cord contusion, a "tooth paste phenomenon" was recognized pathologically. This is a phenomenon that occurs when parenchymal tissue of spinal cord is squeezed and penetrates above and below the level of compression. Gray matter damage was seen 2-4 cm above spinal cord contusion. We considered that spinal cord section compressed spinal cord like spinal contusion
Because such a tooth paste phenomenon occurs when a spinal cord is ligated, transaction with a scalpel, instead of ligation, is desirable to avoid damaging spinal cord. The present study suggests that secondary spinal cord injury occurs several days after spinal cord injury.

  • Research Products

    (6 results)

All 2007 2006

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Invasive features of spinal osteosarcoma obtained from whole-mount sections of total en bloc spondylectomy2007

    • Author(s)
      Murakami H, Kawahara N, Tsuchiya H, Demura S, Yamaguchi T, Tomita K
    • Journal Title

      Journal of Orthopaedic Science 12(3)

      Pages: 311-315

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Invasive features of spinal osteosarcoma obtained from whole-mount sections of total en bloc spondylectomy2007

    • Author(s)
      Murakami, H., Kawahara, N., Tsuchiya, H., Demura, S., Yamaguchi, T., Tomita, K
    • Journal Title

      Journal of Orthopaedic Science 12(3)

      Pages: 311-315

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Complete segmental resection of the spine, Including the spinal cord, for telangiectatic osteosarcoma: a report of 2 cases2006

    • Author(s)
      Murakami H, Tomita K, Kawahara N, Oda M, Yahata T, Yamaguchi T
    • Journal Title

      Spine 31(4)

      Pages: E117-122

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Complete segmental resection of the spine, Including the spinal cord, for telangiectatic osteosarcoma : a report of 2 cases2006

    • Author(s)
      Murakami, H., Tomita, K., Kawahara, N., Oda, M., Yahata, T., Yamaguchi, T
    • Journal Title

      Spine 31(4)

      Pages: 117-122

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] "en bloc"脊椎骨肉腫切除標本から得た新知見の手術へのフィードバック2006

    • Author(s)
      村上英樹
    • Organizer
      日本整形外科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2006-05-17
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Invasive features of spinal osteosarcoma obtained from whole-mount sections of total en bloc spondylectomy2006

    • Author(s)
      Murakami, H
    • Organizer
      Japan Orthopaedic Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-05-17
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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