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Establishment of a novel CAR-T therapy for canine melanoma

Research Project

Project/Area Number 18H02347
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 42020:Veterinary medical science-related
Research InstitutionYamaguchi University

Principal Investigator

Mizuno Takuya  山口大学, 共同獣医学部, 教授 (90398826)

Co-Investigator(Kenkyū-buntansha) 野口 俊助  大阪府立大学, 生命環境科学研究科, 准教授 (10701295)
今村 拓也  広島大学, 統合生命科学研究科(理), 教授 (90390682)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywords犬 / がん / CAR-T / 免疫細胞療法 / キメラ抗原受容体 / メラノーマ / 悪性黒色腫 / イヌ / 腫瘍
Outline of Final Research Achievements

Canine oral melanoma is a highly malignant tumor for which no effective systemic therapy has been established. The purpose of this study was to establish an effective immune cell therapy (CAR-T cell therapy) for oral melanoma and to establish a basic technology for CAR-T cell therapy in dogs by examining detailed conditions such as efficiency and effectiveness of CAR-T cell therapy in dogs.
Unfortunately, we were not able to produce a good CAR-T specific for oral melanoma based on the gene expression profile we obtained, but we were able to examine the conditions for the production of canine CAR-T cells and prove their efficacy in mice.

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた成果は、犬の悪性腫瘍に対する免疫細胞療法としてCAR-T細胞を用いる上での基礎となる情報として非常に重要である。犬のCAR-T細胞療法は、まだ未開拓分野であり、世界的にも着手しているグループは少ない。今回得られた情報をもとにさらに改良をすることにより、犬の悪性腫瘍に対するCAR-T細胞療法が臨床の現場で使用できるようになり、新たな治療オプションとなる可能性がある。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • Research Products

    (3 results)

All 2020 2019

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Optimization of canine CD20 chimeric antigen receptor T cell manufacturing and in vitro cytotoxic activity against B‐cell lymphoma2020

    • Author(s)
      Sakai Osamu、Igase Masaya、Mizuno Takuya
    • Journal Title

      Veterinary and Comparative Oncology

      Volume: 18 Issue: 4 Pages: 739-752

    • DOI

      10.1111/vco.12602

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment and Characterization of Monoclonal Antibody Against Canine CD8 Alpha2020

    • Author(s)
      Sakai Osamu、Ii Tatsuhito、Uchida Kazuyuki、Igase Masaya、Mizuno Takuya
    • Journal Title

      Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

      Volume: 39 Issue: 4 Pages: 129-134

    • DOI

      10.1089/mab.2020.0002

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] Establishment of monoclonal antibody against canine CD20 chimeric antigen receptor T cells2019

    • Author(s)
      Sakai O, Inase M, Mizuno T
    • Organizer
      The 6th Asian Meeting of Animal Medicine Specialties
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-12-25  

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