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Computations and circuit mechanisms underlying odor valence assessment in the higher-order olfactory center

Research Project

Project/Area Number 18H02532
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 46010:Neuroscience-general-related
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Kazama Hokto  国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (90546574)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords嗅覚情報処理 / カルシウムイメージング / ショウジョウバエ / イメージング / パッチクランプ法 / 光遺伝学
Outline of Final Research Achievements

We investigated the computation that takes place in the second-order olfactory processing center of the Drosophila, which is comprised of a relatively small number of cells but whose structure and functions are similar to that of mammals. By developing a technology to record from nearly all the cells in the second-order olfactory processing center, we discovered neurons that encode information about odor valence as hypothesized.

Academic Significance and Societal Importance of the Research Achievements

本研究は、二次嗅覚中枢において匂い嗜好に関する情報がどのように符号化されているかを初めて系統的に明らかにするものと位置づけられる。また、シナプスで直接つながった二層の神経細胞群から、細胞の分解能を保ちつつ網羅的に活動を取得できる系は希有である。ゆえに本研究で開発した実験・データ解析技術は、多層の神経回路でどのような計算がどのようなメカニズムで行われるかという脳科学の根本的な問いに迫ることに資すると期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (20 results)

All 2020 2019 2018

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (14 results) (of which Int'l Joint Research: 4 results,  Invited: 11 results) Book (1 results)

  • [Journal Article] Synthesis of conserved odor object representations in a random, divergent-convergent network.2020

    • Author(s)
      Endo K, Tsuchimoto Y, Kazama H
    • Journal Title

      Neuron

      Volume: 108 Issue: 2 Pages: 367-381

    • DOI

      10.1016/j.neuron.2020.07.029

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A multi-regional network encoding heading and steering maneuvers in Drosophila2020

    • Author(s)
      Shiozaki HM, Ohta K, Kazama H
    • Journal Title

      Neuron

      Volume: 106 Issue: 1 Pages: 126-141

    • DOI

      10.1016/j.neuron.2020.01.009

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanopore Formation in the Cuticle of an Insect Olfactory Sensillum2019

    • Author(s)
      Toshiya Ando, Sayaka Sekine, Sachi Inagaki, Kazuyo Misaki , Laurent Badel, Hiroyuki Moriya, Mustafa M. Sami, Yuki Itakura, Takahiro Chihara, Hokto Kazama , Shigenobu Yonemura, Shigeo Hayashi
    • Journal Title

      Current Biology

      Volume: 29 Issue: 9 Pages: 1512-1520

    • DOI

      10.1016/j.cub.2019.03.043

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circuits and neural dynamics underlying behavior2019

    • Author(s)
      Fujisawa S, Kazama H
    • Journal Title

      Neuroscience Research

      Volume: 140 Pages: 1-2

    • DOI

      10.1016/j.neures.2019.01.002

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Olfactory landmark-based communication in interacting Drosophila2018

    • Author(s)
      Mercier D, Tsuchimoto Y, Ohta K, Kazama H
    • Journal Title

      Current Biology

      Volume: 28 Issue: 16 Pages: 2624-2631

    • DOI

      10.1016/j.cub.2018.06.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dynamics of olfactory representations in the Drosophila memory center2020

    • Author(s)
      Hokto Kazama
    • Organizer
      Neuroscience2020
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 脳が世界を感じるしくみ―匂い空間における探索―2020

    • Author(s)
      Hokto Kazama
    • Organizer
      科学技術広報研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Decoding of olfactory computations in the brain.2020

    • Author(s)
      Hokto Kazama
    • Organizer
      Kyoto University
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Neural basis of odor-taste multisensory integration in Drosophila2019

    • Author(s)
      Hokto Kazama
    • Organizer
      42nd Annual meeting of the molecular biology society of Japan
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 動物のナビゲーションを支える神経回路のしくみを解く―顕微鏡と仮想空間の融合がもたらすソリューション―2019

    • Author(s)
      Hokto Kazama
    • Organizer
      42nd Annual meeting of the molecular biology society of Japan
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Odor-taste multisensory integration in Drosophila2019

    • Author(s)
      Hokto Kazama
    • Organizer
      Naito Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 記憶中枢における匂いオブジェクトの生成2019

    • Author(s)
      Hokto Kazama
    • Organizer
      Neuroscience2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ショウジョウバエの脳高次機能の限界はどこにあるのか?―顕微鏡周りに広がる無限の可能性―2019

    • Author(s)
      Hokto Kazama
    • Organizer
      52nd Annual meeting of the Japanese society of developmental biologists
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Plasticity and stability of olfactory representations in the Drosophila memory center2018

    • Author(s)
      Hokto Kazama
    • Organizer
      Neuroscience2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Synthesis of unitary odor object representations in an association area2018

    • Author(s)
      Hokto Kazama
    • Organizer
      International workshop on olfaction
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neural dynamics encoding flight steering maneuvers in the fan-shaped body of Drosophila2018

    • Author(s)
      Hiroshi Shiozaki, Ohta K, Kazama H
    • Organizer
      Structure and Function of the Insect Central Complex
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural dynamics during flight orientation in the central brain of Drosophila2018

    • Author(s)
      Hiroshi Shiozaki, Kazama H
    • Organizer
      Neuroscience2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Odor-taste multisensory integration in Drosophila2018

    • Author(s)
      Hongping Wei, Kazama H
    • Organizer
      Neuroscience2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Bioluminescence neural-monitoring reveals olfactory landmark-based communication in interacting Drosophila2018

    • Author(s)
      Mercier D, Tsuchimoto Y, Ohta K, Kazama H
    • Organizer
      International workshop on olfaction
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Book] 実験医学別冊 発光イメージング実験ガイド (永井健治、小澤岳昌編集)2020

    • Author(s)
      Damien Mercier、髙木(槌本)佳子、太田和美、風間北斗
    • Total Pages
      222
    • Publisher
      羊土社
    • ISBN
      9784758122405
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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