Computations and circuit mechanisms underlying odor valence assessment in the higher-order olfactory center
| Project/Area Number |
18H02532
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 46010:Neuroscience-general-related
|
|---|
| Research Institution | Institute of Physical and Chemical Research |
|---|
Principal Investigator |
Kazama Hokto 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (90546574)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
|
|---|
| Keywords | 嗅覚情報処理 / カルシウムイメージング / ショウジョウバエ / イメージング / パッチクランプ法 / 光遺伝学 |
|---|
| Outline of Final Research Achievements |
We investigated the computation that takes place in the second-order olfactory processing center of the Drosophila, which is comprised of a relatively small number of cells but whose structure and functions are similar to that of mammals. By developing a technology to record from nearly all the cells in the second-order olfactory processing center, we discovered neurons that encode information about odor valence as hypothesized.
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究は、二次嗅覚中枢において匂い嗜好に関する情報がどのように符号化されているかを初めて系統的に明らかにするものと位置づけられる。また、シナプスで直接つながった二層の神経細胞群から、細胞の分解能を保ちつつ網羅的に活動を取得できる系は希有である。ゆえに本研究で開発した実験・データ解析技術は、多層の神経回路でどのような計算がどのようなメカニズムで行われるかという脳科学の根本的な問いに迫ることに資すると期待される。
|
Report
(4 results)
Research Products
(20 results)
-
-
-
[Journal Article] Nanopore Formation in the Cuticle of an Insect Olfactory Sensillum2019
Author(s)
Toshiya Ando, Sayaka Sekine, Sachi Inagaki, Kazuyo Misaki , Laurent Badel, Hiroyuki Moriya, Mustafa M. Sami, Yuki Itakura, Takahiro Chihara, Hokto Kazama , Shigenobu Yonemura, Shigeo Hayashi
-
Journal Title
Current Biology
Volume: 29
Issue: 9
Pages: 1512-1520
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
