Comprehensive analyses of connectivity pathology of schizophrenia: next generation connectivity analyses using higher magnetic field MRI

• Project/Area Number: 18H02749
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Kyoto University
• Principal Investigator: Murai Toshiya 京都大学, 医学研究科, 教授 (30335286)
• Co-Investigator(Kenkyū-buntansha): 岡田 知久 京都大学, 医学研究科, 特定准教授 (30321607) ; 宮田 淳 京都大学, 医学研究科, 講師 (90549099)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 統合失調症 / MRI

Outline of Final Research Achievements

To investigate connectivity pathology of schizophrenia, we performed high angular resolution MRI scanning (3 tesla) and higher magnetic field MRI scanning (7 tesla) in schizophrenia as well as in normal healthy subjects. Using the 3 tesla MRI data, we performed Neurite Orientation Dispersion and Density Imaging (NODDI), Fixel-Based Analysis, Free Water Imaging, as well as Myelin Mapping, and revealed white matter pathology associated with schizophrenia. As for the 7 tesla MRI, we developed a protocol to investigate resting state functional MRI data, which enables functional connectivity analyses involving small brain structures.

Academic Significance and Societal Importance of the Research Achievements

統合失調症の原因はいまだ不明であるが、その一つの可能性として、脳内の神経結合（脳の個別の場所の間の連絡）の異常があることが先行研究から推定されている。しかしながら、人の脳で神経結合の詳細な観察を行うには、これまでいくつもの技術的な限界があった。今回の研究では、高性能の脳画像技術（高傾斜磁場MRI、高磁場MRI）、および先端の画像解析技術を用いることで、従来では観察することが困難であった水準で、統合失調症の神経結合の病理を画像化することに成功した。

Research Products

• [Journal Article] Enhanced Carbonyl Stress and Disrupted White Matter Integrity in Schizophrenia. (2020)
  • Author(s): Son S, Arai M, Toriumi K, Mizuta H, Miyata J, Hayashi T, Aso T, Itokawa M, Murai T.
  • Journal Title: Schizophr Res Volume: 223 Pages: 242-248
  • DOI: 10.1016/j.schres.2020.08.007
  • Peer Reviewed / Open Access
• [Journal Article] Gray matter volume reductions in patients with schizophrenia: A replication study across two cultural backgrounds (2019)
  • Author(s): Koelkebeck Katja、Dannlowski Udo、Ohrmann Patricia、Suslow Thomas、Murai Toshiya、Bauer Jochen、Pedersen Anya、Matsukawa Noriko、Son Shuraku、Haidl Theresa、Miyata Jun
  • Journal Title: Psychiatry Research: Neuroimaging Volume: 292 Pages: 32-40
  • DOI: 10.1016/j.pscychresns.2019.08.008
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 精神科臨床での神経心理・神経画像検査の意義 (2020)
  • Author(s): 村井俊哉
  • Organizer: 第116回日本精神神経学会学術総会
  • Invited
• [Presentation] 統合失調症画像研究の最近の進歩と今後の展望 (2019)
  • Author(s): 村井俊哉
  • Organizer: 第１４回日本統合失調症学会学術総会
  • Invited
• [Book] 統合失調症 (2019)
  • Author(s): 村井俊哉
  • Total Pages: 200
  • Publisher: 岩波書店
  • ISBN: 4004318017