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節足動物媒介ウイルスの特異な感染現象を反映したゲノム改変型宿主細胞の開発

Research Project

Project/Area Number 18H02856
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 54030:Infectious disease medicine-related
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

伊澤 晴彦  国立感染症研究所, 昆虫医科学部, 室長 (90370965)

Co-Investigator(Kenkyū-buntansha) 深澤 征義  国立感染症研究所, 細胞化学部, 部長 (20291130)
駒形 修  国立感染症研究所, 昆虫医科学部, 主任研究官 (20435712)
沢辺 京子  国立感染症研究所, 昆虫医科学部, 主任研究官 (10215923)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords節足動物媒介性ウイルス / 宿主細胞 / ゲノム科学 / ゲノム編集 / バイオインフォマティクス
Outline of Annual Research Achievements

前年度までに作出に成功したネッタイシマカ由来新規培養細胞系AeAe-GH98について、各種蚊媒介性フラビウイルス(デングウイルス、黄熱ウイルス、ジカウイルス)に対し異なる感受性を示す遺伝的な背景を調べる目的で、これらフラビウイルス感染に際して応答する遺伝子をトランスクリプトーム解析で調査し、特徴的な発現動態を示す候補遺伝子を複数見出した。蚊媒介性アルファウイルスの一種であるゲタウイルスについて、各種蚊由来培養細胞系を用いてその感受性を検討した結果、培養細胞の由来する蚊の属によって異なる感受性と細胞障害性を示す結果が得られ、宿主特異性との関連が示唆された。既存のマダニ由来培養細胞には複数のウイルスが潜在的に感染していることが判明したため、薬剤による除去を試みている。
前年度までにコガタアカイエカ由来NIID-CTR細胞のゲノム配列を取得しているが、正確な遺伝子予測を行うために、島根県由来のコガタアカイエカ飼育系統の昆虫個体を用いてRNA-seq解析を行った。また、同島根県由来のコガタアカイエカのオス個体について全ゲノムシーケンシングおよびde novo assemblyを行った。この配列をもとに培養細胞と個体との間で比較ゲノム解析を行い、細胞不死化ともなうゲノム上の変化を明らかにできると期待される。
Vero細胞において、日本脳炎ウイルス(JEV)rAT株の持続感染細胞株を樹立した。また、シンドビスウイルス(SINV)とJEVの共持続感染細胞も樹立できた。これら細胞株は1年間以上にわたり、持続感染を維持できることも確認した。SINV単独の持続感染細胞は樹立できなかった。非感染・JEV一過性感染・持続感染細胞(2種)間での遺伝子発現パターンを比較し,各感染形態に特徴的な遺伝子発現変化の情報を得て、変化の見られた遺伝子についてウイルス増殖・持続性獲得に対する影響を解析している。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Report

(3 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(44 results)

All 2022 2021 2020 2019 2018

All Journal Article (20 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 20 results,  Open Access: 14 results) Presentation (24 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Detection of Quaranjavirus-Like Sequences from <i>Haemaphysalis hystricis</i> Ticks Collected in Japan2022

    • Author(s)
      Kobayashi Daisuke、Kuwata Ryusei、Kimura Toshiya、Faizah Astri Nur、Higa Yukiko、Hayashi Toshihiko、Sawabe Kyoko、Isawa Haruhiko
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 75 Issue: 2 Pages: 195-198

    • DOI

      10.7883/yoken.jjid.2021.129

      10.7883/yoken.JJID.2021.129

    • NAID

      130008080718

    • ISSN
      1344-6304, 1884-2836
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] L-DOPA, a treatment for Parkinson's disease, and its enantiomer D-DOPA inhibit severe fever with thrombocytopenia syndrome virus infection in vitro2022

    • Author(s)
      Ogawa Motohiko、Murae Mana、Gemba Ryutaro、Irie Takuya、Shimojima Masayuki、Saijo Masayuki、Noguchi Kohji、Fukasawa Masayoshi
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 28 Pages: 373-376

    • DOI

      10.1016/j.jiac.2021.11.005

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of a Novel Flavivirus (Flaviviridae) From the Horse Fly, Tabanus rufidens (Diptera: Tabanidae): The Possible Coevolutionary Relationships Between the Classical Insect-Specific Flaviviruses and Host Dipteran Insects2021

    • Author(s)
      Kobayashi Daisuke、Watanabe Mamoru、Faizah Astri Nur、Amoa-Bosompem Michael、Higa Yukiko、Tsuda Yoshio、Sawabe Kyoko、Isawa Haruhiko
    • Journal Title

      Journal of Medical Entomology

      Volume: 58 Pages: 880-890

    • DOI

      10.1093/jme/tjaa193

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Determining vector competence of Aedes aegypti from Ghana in transmitting dengue virus serotypes 1 and 22021

    • Author(s)
      Amoa-Bosompem Michael、Kobayashi Daisuke、Itokawa Kentaro、Murota Katsunori、Faizah Astri Nur、Azerigyik Faustus Akankperiwen、Hayashi Takaya、Ohashi Mitsuko、Bonney Joseph H. Kofi、Dadzie Samuel、Tran Cuong Chi、Tran Phong Vu、Fujita Ryosuke、Maekawa Yoshihide、Kasai Shinji、Yamaoka Shoji、Ohta Nobuo et al.
    • Journal Title

      Parasites & Vectors

      Volume: 14 Pages: 228-228

    • DOI

      10.1186/s13071-021-04728-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Toyo virus, a novel member of the Kaisodi group in the genus Uukuvirus (family Phenuiviridae) found in Haemaphysalis formosensis ticks in Japan2021

    • Author(s)
      Kobayashi Daisuke、Kuwata Ryusei、Kimura Toshiya、Faizah Astri Nur、Higa Yukiko、Hayashi Toshihiko、Sawabe Kyoko、Isawa Haruhiko
    • Journal Title

      Archives of Virology

      Volume: 166 Pages: 2751-2762

    • DOI

      10.1007/s00705-021-05193-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of Jingmenviruses in Japan with Evidence of Vertical Transmission in Ticks2021

    • Author(s)
      Kobayashi Daisuke、Kuwata Ryusei、Kimura Toshiya、Shimoda Hiroshi、Fujita Ryosuke、Faizah Astri Nur、Kai Izumi、Matsumura Ryo、Kuroda Yudai、Watanabe Shumpei、Kuniyoshi Sawako、Yamauchi Takeo、Watanabe Mamoru、Higa Yukiko、Hayashi Toshihiko、Shinomiya Hiroto、Maeda Ken、Kasai Shinji、Sawabe Kyoko、Isawa Haruhiko
    • Journal Title

      Viruses

      Volume: 13 Pages: 2547-2547

    • DOI

      10.3390/v13122547

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Screening for tick-borne and tick-associated viruses in ticks collected in Ghana2021

    • Author(s)
      Amoa-Bosompem Michael、Kobayashi Daisuke、Faizah Astri Nur、Kimura Shohei、Antwi Ama、Agbosu Esinam、Pratt Deborah、Ohashi Mitsuko、Bonney Joseph H. Kofi、Dadzie Samuel、Ejiri Hiroko、Ohta Nobuo、Sawabe Kyoko、Iwanaga Shiroh、Isawa Haruhiko
    • Journal Title

      Archives of Virology

      Volume: 167 Pages: 123-130

    • DOI

      10.1007/s00705-021-05296-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antiviral Effects of the Anti-Occludin Monoclonal Antibody on Persistent Hepatitis C Virus Infection in a Human Liver Chimeric Mouse Model2021

    • Author(s)
      Shimizu Yoshimi、Suzuki Takeru、Shirasago Yoshitaka、Kondoh Masuo、Suzuki Tetsuro、Wakita Takaji、Fukasawa Masayoshi
    • Journal Title

      BPB Reports

      Volume: 4 Issue: 5 Pages: 142-147

    • DOI

      10.1248/bpbreports.4.5_142

    • NAID

      130008089064

    • ISSN
      2434-432X
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural basis of antiviral activity of caffeic acid against severe fever with thrombocytopenia syndrome virus2021

    • Author(s)
      Ogawa Motohiko、Shirasago Yoshitaka、Tanida Isei、Kakuta Soichiro、Uchiyama Yasuo、Shimojima Masayuki、Hanada Kentaro、Saijo Masayuki、Fukasawa Masayoshi
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 27 Pages: 397-400

    • DOI

      10.1016/j.jiac.2020.10.015

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occludin‐binding single‐chain variable fragment and antigen‐binding fragment antibodies prevent hepatitis C virus infection2021

    • Author(s)
      Shimizu Yoshimi、Shinoda Takehiro、Shirasago Yoshitaka、Kondoh Masuo、Shinya Naoko、Hanada Kentaro、Yagi Kiyohito、Suzuki Tetsuro、Wakita Takaji、Kimura‐Someya Tomomi、Shirouzu Mikako、Fukasawa Masayoshi
    • Journal Title

      FEBS letters

      Volume: 595 Pages: 220-229

    • DOI

      10.1002/1873-3468.13975

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Several catechins and flavonols from green tea inhibit severe fever with thrombocytopenia syndrome virus infection in vitro2021

    • Author(s)
      Ogawa Motohiko、Shimojima Masayuki、Saijo Masayuki、Fukasawa Masayoshi
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 27 Pages: 32-39

    • DOI

      10.1016/j.jiac.2020.08.005

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Entomological Assessment of the Status and Risk of Mosquito-borne Arboviral Transmission in Ghana2020

    • Author(s)
      Amoa-Bosompem M, Kobayashi D, Murota K, Faizah A N、Itokawa K、Fujita R、Osei Joseph H N、Agbosu E、Pratt D、Kimura S、Kwofie Kofi D、Ohashi M、Bonney Joseph H. K、Dadzie S、Sasaki T、Ohta N、Isawa H、Sawabe K、Iwanaga S
    • Journal Title

      Viruses

      Volume: 12 Pages: 147-147

    • DOI

      10.3390/v12020147

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deciphering the Virome of Culex vishnui Subgroup Mosquitoes, the Major Vectors of Japanese Encephalitis, in Japan2020

    • Author(s)
      Faizah Astri Nur、Kobayashi Daisuke、Isawa Haruhiko、Amoa-Bosompem Michael、Murota Katsunori、Higa Yukiko、Futami Kyoko、Shimada Satoshi、Kim Kyeong Soon、Itokawa Kentaro、Watanabe Mamoru、Tsuda Yoshio、Minakawa Noboru、Miura Kozue、Hirayama Kazuhiro、Sawabe Kyoko
    • Journal Title

      Viruses

      Volume: 12 Pages: 264-264

    • DOI

      10.3390/v12030264

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment and characterization of a cell line from Ghanaian Aedes aegypti (Diptera: Culicidae) focusing on Aedes-borne flavivirus susceptibility2020

    • Author(s)
      Amoa-Bosompem Michael、Kobayashi Daisuke、Itokawa Kentaro、Faizah Astri Nur、Kuwata Ryusei、Dadzie Samuel、Hayashi Takaya、Yamaoka Shoji、Sawabe Kyoko、Iwanaga Shiroh、Isawa Haruhiko
    • Journal Title

      In Vitro Cellular & Developmental Biology - Animal

      Volume: 56 Pages: 792-798

    • DOI

      10.1007/s11626-020-00504-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RNA virome analysis of questing ticks from Hokuriku District, Japan, and the evolutionary dynamics of tick-borne phleboviruses2020

    • Author(s)
      Kobayashi Daisuke、Murota Katsunori、Itokawa Kentaro、Ejiri Hiroko、Amoa-Bosompem Michael、Faizah Astri Nur、Watanabe Mamoru、Maekawa Yoshihide、Hayashi Toshihiko、Noda Shinichi、Yamauchi Takeo、Komagata Osamu、Sawabe Kyoko、Isawa Haruhiko
    • Journal Title

      Ticks and Tick-borne Diseases

      Volume: 11 Pages: 101364-101364

    • DOI

      10.1016/j.ttbdis.2019.101364

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluating the competence of the primary vector, Culex tritaeniorhynchus, and the invasive mosquito species, Aedes japonicus japonicus, in transmitting three Japanese encephalitis virus genotypes2020

    • Author(s)
      Faizah Astri Nur、Kobayashi Daisuke、Amoa-Bosompem Michael、Higa Yukiko、Tsuda Yoshio、Itokawa Kentaro、Miura Kozue、Hirayama Kazuhiro、Sawabe Kyoko、Isawa Haruhiko
    • Journal Title

      PLOS Neglected Tropical Diseases

      Volume: 14

    • DOI

      10.1371/journal.pntd.0008986

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition Mechanisms of Hepatitis C Virus Infection by Caffeic Acid and Tannic Acid2019

    • Author(s)
      Shirasago Yoshitaka、Inamori Yoko、Suzuki Takeru、Tanida Isei、Suzuki Tetsuro、Sugiyama Kazuo、Wakita Takaji、Hanada Kentaro、Fukasawa Masayoshi
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 42 Issue: 5 Pages: 770-777

    • DOI

      10.1248/bpb.b18-00970

    • NAID

      130007641446

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human-rat chimeric anti-occludin monoclonal antibodies inhibit hepatitis C virus infection2019

    • Author(s)
      Shimizu Yoshimi、Yoneda Kohei、Shirasago Yoshitaka、Suzuki Takeru、Tada Minoru、Ishii-Watabe Akiko、Sugiyama Kazuo、Suzuki Tetsuro、Wakita Takaji、Yagi Kiyohito、Kondoh Masuo、Fukasawa Masayoshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 514 Pages: 785-790

    • DOI

      10.1016/j.bbrc.2019.05.019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of monoclonal antibodies recognizing each extracellular loop domain of occludin2019

    • Author(s)
      Shimizu Yoshimi、Shirasago Yoshitaka、Suzuki Takeru、Hata Tomoyuki、Kondoh Masuo、Hanada Kentaro、Yagi Kiyohito、Fukasawa Masayoshi
    • Journal Title

      Journal of Biochemistry

      Volume: 166 Pages: 297-308

    • DOI

      10.1093/jb/mvz037

    • NAID

      40022023629

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Persistent viruses in mosquito cultured cell line suppress multiplication of flaviviruses2018

    • Author(s)
      Fujita Ryosuke、Kato Fumihiro、Kobayashi Daisuke、Murota Katsunori、Takasaki Tomohiko、Tajima Shigeru、Lim Chang-Kweng、Saijo Masayuki、Isawa Haruhiko、Sawabe Kyoko
    • Journal Title

      Heliyon

      Volume: 4

    • DOI

      10.1016/j.heliyon.2018.e00736

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] キンイロヌマカのRNAウイルス叢解析および分離された新規フラビウイルスの性状解析2022

    • Author(s)
      松村凌, 小林大介, 渡辺護, 比嘉由紀子, 沢辺京子, 伊澤晴彦, 糸山享
    • Organizer
      第66回日本応用動物昆虫学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] アオダイショウ由来培養細胞の性状解析2021

    • Author(s)
      鍬田龍星, 黒木俊郎, 松井利康, 石嶋慧多, 立本完吾, 小林大介, 伊澤晴彦, 高野愛, 下田宙, 藤井ひかる, 畑明寿, 宇根有美, 森川茂, 前田健, 吉川泰弘
    • Organizer
      第73回日本衛生動物学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] キンイロヌマカから分離された新規フラビウイルスの性状解析2021

    • Author(s)
      松村凌, 小林大介, 渡辺護, 比嘉由紀子, 沢辺京子, 糸山享, 伊澤晴彦
    • Organizer
      第73回日本衛生動物学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ガーナ産ネッタイシマカ由来新規培養細胞系の樹立と性状解析2021

    • Author(s)
      伊澤晴彦, マイケル・アモア-ボソムペム, 小林大介, 鍬田龍星, 糸川健太郎, アシトリ・ヌー・ファイザー, 岩永史朗
    • Organizer
      第73回日本衛生動物学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Evaluation of the growth kinetics of Getah virus in a scope of mosquito cell lines2021

    • Author(s)
      Azerigyik F, Kobayashi D, Amoa-Bosompem M, Faizah AN, Iwanaga S, Isawa H
    • Organizer
      第73回日本衛生動物学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] アオダイショウおよびシマヘビ由来培養細胞の性状解析2021

    • Author(s)
      鍬田龍星,黒木俊郎,松井利康,石嶋慧多,立本完吾,小林大介,伊澤晴彦,高野愛,下田宙,藤井ひかる,宇根有美,森川茂,前田健,吉川泰弘
    • Organizer
      第164回日本獣医学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Evaluation of the growth kinetics of Getah virus in a scope of mammalian and mosquito cell cultures2021

    • Author(s)
      Azerigyik FA, Kobayashi D, Amoa-Bosompem M, Faizah AN, Iwanaga S, Isawa H
    • Organizer
      American Society of Tropical Medicine & Hygiene 70th Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Arbovirus surveillance and Japanese encephalitis virus genotype IV isolation from Culex vishnui mosquitoes collected on Bali Island, Indonesia2021

    • Author(s)
      Faizah AN, Kobayashi D, Maekawa Y, Amoa-Bosompem M, Fauziyah S, Mulyatno KC, Subekti S, Rohmah EA, Lusida MI, Mori Y, Miura K, Hirayama K, Isawa H, Sawabe K
    • Organizer
      American Society of Tropical Medicine & Hygiene 70th Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 蚊・マダニ由来培養細胞に潜在感染するウイルスの探索と同定2020

    • Author(s)
      松村凌, 小林大介, Astri Nur Faizah, 糸山享, 伊澤晴彦
    • Organizer
      第72回日本衛生動物学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ネッタイシマカのデングウイルス感受性関連遺伝子の解析2020

    • Author(s)
      佐々木年則, ベルツーソ・G・アーリン,伊澤晴彦,高崎智彦, 皆川昇, 沢辺京子
    • Organizer
      第72回日本衛生動物学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 本邦産ヒトスジシマカのデングウイルス感受性2019

    • Author(s)
      佐々木年則,小滝徹,田島茂,モイ・メンリン,斎藤一三,林昌宏,小林大介,伊澤晴彦,高崎智彦,沢辺京子
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Comparing the competence of Ghanaian and Vietnamese Aedes mosquitoes as vectors of the dengue virus2019

    • Author(s)
      Michael Amoa-Bosompem, Daisuke Kobayashi, Katsunori Murota, Astri Nur Faizah, Mitsuko Ohashi, Toshinori Sasaki, Haruhiko Isawa, Kyoko Sawabe, Shiro Iwanaga
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] コガタアカエイカ NIID-CTR 細胞の新規全ゲノムアセンブリ2019

    • Author(s)
      糸川健太郎,小林大介,伊澤晴彦,比嘉由紀子,葛西真治,駒形修,冨田隆史,黒田誠, 沢辺京子
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Virome analysis of Japanese encephalitis vector, Culex tritaeniorhynchus, collected from three prefectures in Japan2019

    • Author(s)
      Astri Nur Faizah, Daisuke Kobayashi, Michael Amoa-Bosompem, Haruhiko Isawa, Kyeong Soon Kim, Mamoru Watanabe, Kozue Miura, Kazuhiro Hirayama, Kyoko Sawabe
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 次世代シークエンサーを用いたマダニ保有ウイルスのサーベイランス2019

    • Author(s)
      小林大介, Astri Nur Faizah, Michael Amoa-bosompem, 室田勝功, 糸川健太郎, 渡辺護, 比嘉由紀子, 前川芳秀, 沢辺京子, 伊澤晴彦
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
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      伊澤晴彦, 江尻寛子, 林昌宏,藤田龍介,室田勝功,小林大介,鍬田龍星,下田宙,前田健, 菅美樹,木村俊也,四宮博人,沢辺京子
    • Organizer
      第71回日本衛生動物学会大会
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  • [Presentation] ツシマヤマネコ咬着タカサゴキララマダニからの Jingmen tick virus の分離2019

    • Author(s)
      藤田龍介, 江尻寛子, 山内健生, 糸川健太郎, 伊澤晴彦, 小林大介, 室田勝功, 前川芳秀, 沢辺京子
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      第71回日本衛生動物学会大会
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      室田勝功,白藤浩明,石井圭子,小林大介,伊澤晴彦,梁瀬徹
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      第71回日本衛生動物学会大会
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      第71回日本衛生動物学会大会
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    • Author(s)
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    • Organizer
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    • Author(s)
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    • Author(s)
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    • Organizer
      ASTMH 68th Annual Meeting
    • Related Report
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Published: 2018-04-23   Modified: 2022-12-28  

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