NKT cell-targeted cancer immunotherapy based on the comprehension of anti-tumor immune response in the lung cancer microenvironment
Project/Area Number |
18H02892
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 55040:Respiratory surgery-related
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Research Institution | Chiba University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
木村 元子 千葉大学, 大学院医学研究院, 准教授 (00345018)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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Keywords | 免疫療法 / 肺癌 / 抗腫瘍免疫抑制 |
Outline of Final Research Achievements |
The purpose of this study is to develop a new cancer immunotherapy for lung cancer by understanding the immune response occurring in the tumor environment including regional lymph nodes that are metastasis routes of cancer. The novel T cell population found in this study expresses markers associated with tissue residency in regional lymph nodes of lung cancer, and can be related to the pathophysiology and progression of lung cancer. In addition, we identified multiple protein candidates, which are produced from tumor cell lines to be responsible for the suppression of anti-tumor immune responses. In the future, we aim to clarify the mechanism of action and the method to overcome the suppression of anti-cancer immune responses toward the development of a new cancer immunotherapy.
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Academic Significance and Societal Importance of the Research Achievements |
今回発見した新たなT細胞集団が、肺癌の病態や進行と関連している可能性があり、このT細胞をモニターすることで、治療の効果判定や適切な治療法選択のマーカーとなる可能性がある。また腫瘍から産生される免疫抑制タンパク質を介した免疫抑制状態を解除することが可能となれば、全身的な免疫状態の改善につながり、標準治療となったがん免疫療法の有効性を大きく改善する可能性が高く、がん治療の成績向上に貢献する。
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Phase II study of α-galactosylceramide-pulsed antigen-presenting cells in patients with advanced or recurrent non-small cell lung cancer2020
Author(s)
Toyoda, T., Kamata, T., Tanaka, K., Ihara, F., Takami, M., Suzuki, H., Nakajima, T., Ikeuchi, T., Kawasaki, Y., Hanaoka, H., Nakayama, T., Yoshino, I., and Motohashi, S.
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Journal Title
J. Immunother. Cancer
Volume: 8
Issue: 1
Pages: e000316-e000316
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immunological Features of a Lung Cancer Patient Achieving an Objective Response with Anti-PD-1 Blockade Therapy2019
Author(s)
Kamata, T., Yoshida, S., Takami, M., Ihara, F., Yoshizawa, H., Toyoda, T., Takeshita, Y., Nobuyama, S., Kanetsuna, Y., Sato, T., Yoshino, I., and Motohashi, S.
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Journal Title
Cancer Sci.
Volume: 111
Issue: 1
Pages: 288-296
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Regulatory T cells induce CD4- NKT cell anergy and suppress NKT cell cytotoxic function2019
Author(s)
Ihara, F., Sakurai, D., Takami, M., Kamata, T., Kunii, N., Yamasaki, K., Iinuma, T., Nakayama, T., Motohashi, S., and Okamoto, Y.
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Journal Title
Cancer Immunol. Immunother
Volume: 68
Issue: 12
Pages: 1935-1947
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation2019
Author(s)
Harada, K., Ihara, F., Takami, M., Kamata, T., Mise, N., Yoshizawa, H., Hishiki, T., Saito, T., Terui, K., Nakata, M., Komatsu, S., Ikeuchi, T., Nakayama, T., Yoshida, H., Motohashi, S.
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Journal Title
Cancer Sci.
Volume: 110
Issue: 3
Pages: 888-902
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer2018
Author(s)
Tanaka K, Kanesaka Y, Takami M, Suzuki A, Hosokawa H, Onodera A, Kamata T, Nagato K, Nakayama T, Yoshino I, Motohashi S
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Journal Title
Biochem Biophys Res Commun.
Volume: 506(1)
Issue: 1
Pages: 27-32
DOI
Related Report
Peer Reviewed
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[Presentation] CD1d expression in glioblastoma is a promising target for NKT cell- based cancer immunotherapy2019
Author(s)
Hara, A., Nasu, R., Takami, M., Hirono, S., Matsutani, T., Nakayama, T., Iwadate, Y., Motohashi, S.
Organizer
第78回日本癌学会学術総会
Related Report
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[Presentation] CD1d expression in glioblastoma is a promising target for NKT cell- based cancer immunotherapy2019
Author(s)
Hara, A., Nasu, R., Takami, M., Hirono, S., Matsutani, T., Nakayama, T., Iwadate, Y., Motohashi, S.
Organizer
EMBO workshop CD1-MR1
Related Report
Int'l Joint Research
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[Presentation] Invariant NKT cells target CD1d-negative leukemia cells with TCR and NK receptors2019
Author(s)
Aoki, T., Takami, M., Takatani, T., Motoyoshi, K., Ishii, A., Hara, A., Hino, M., Shimojo, N., Motohashi, S.
Organizer
EMBO workshop CD1-MR1
Related Report
Int'l Joint Research
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[Presentation] Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation2019
Author(s)
Yoshizawa, H., Harada, K., Ishii, A., Mise, N., Hishiki, T., Saito, K., Nakata, M., Komatsu, S., Nakayama, T., Yoshida, H., Takami, M., Motohashi, S.
Organizer
EMBO workshop CD1-MR1
Related Report
Int'l Joint Research
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[Presentation] Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation2019
Author(s)
原田和明, 吉澤比呂子, 三瀬直子, 小松秀吾, 中田光政, 照井慶太, 齋藤武, 石井絢菜, 高見真理子, 吉田英生, 本橋新一郎
Organizer
第23回日本がん免疫学会総会
Related Report
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[Presentation] 神経芽腫細胞由来の液性因子による樹状細胞への抑制効果の検討2019
Author(s)
原田 和明, 齋藤 武, 照井 慶太, 中田 光政, 小松 秀吾, 秦 佳孝, 吉澤 比呂子, 工藤 渉, 古金 遼也, 高見 真理子, 本橋 新一郎, 吉田 英生
Organizer
第56回日本小児外科学会学術集会
Related Report
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[Presentation] マスサイトメトリーによる肺癌所属リンパ節の免疫細胞解析2019
Author(s)
豊田 行英, 本橋 新一郎, 植松 靖文, 清水 大貴, 今林 宏樹, 小野里 優希, 松本 寛樹, 伊藤 祐輝, 海寳 大輔, 椎名 裕樹, 佐田 諭己, 山本 高義, 田中 教久, 坂入 祐一, 和田 啓伸, 鈴木 秀海, 中島 崇裕, 吉野 一郎
Organizer
第36回日本呼吸器外科学会学術集会
Related Report
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[Presentation] Double-Stranded RNA Derived from Lactic Acid Bacteria Augments Th1 Immunity via Interferon-β from Human Dendritic Cells2018
Author(s)
Ikari, N., Kawashima, T., Kubota, Y., Motohashi, S., Shimojo, N., Tsuji, N. M.
Organizer
International Symposium of International Scientific Association for Probiotics and Prebiotics 2018
Related Report
Int'l Joint Research
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[Presentation] Crucial role for CD69 in anti-tumor immunity2018
Author(s)
Mita, Y., Kimura, M., Nasu, R., Motohashi, S., Okamoto, Y., Nakayama, T.
Organizer
第77回日本癌学会学術総会
Related Report
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[Presentation] Anti-tumor immunity via the superoxide-eosinophil axis induced by lipophilic component of Mycobacterium lipomannan2018
Author(s)
Ito, T., Hirahara, K., Nasu, R., Yano, I., Motohashi, S., Nakayama, T.
Organizer
第77回日本癌学会学術総会
Related Report
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[Presentation] Role of CD69 on iNKT cell development in the thymus2018
Author(s)
Kimura, M. Y., Hayashizaki, K., Yagi, R., Endo, Y., Motohashi, S., Nakayama, T.
Organizer
第47回日本免疫学会学術集会
Related Report
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[Presentation] A Phase II study of α-Galactosylceramide-pulsed antigen presenting cells for advanced or recurrent non-small cell lung cancer2018
Author(s)
Motohashi, S., Kamata, T., Toyoda, T., Tanaka, T., Ihara, F., Takami, M., Yosino, I., Nakayama, T.
Organizer
第47回日本免疫学会学術集会
Related Report