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Study for establishment of next-generation caries management method using dentin remineralization/regeneration technology

Research Project

Project/Area Number 18H02979
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

斎藤 隆史  北海道医療大学, 歯学部, 教授 (40265070)

Co-Investigator(Kenkyū-buntansha) 村田 勝  北海道医療大学, 歯学部, 教授 (00260662)
伊藤 修一  北海道医療大学, 歯学部, 教授 (50382495)
松田 康裕  北海道医療大学, 歯学部, 准教授 (50431317)
別所 和久  京都大学, 医学研究科, 教授 (90229138)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2021: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywords象牙質の再生 / う蝕治療 / 象牙質再石灰化 / 修復象牙質形成 / 接着性モノマー / 脱灰象牙質再石灰化 / 齲蝕治療 / 修復象牙質形成誘導 / 齲蝕予防 / 象牙質齲蝕 / 再石灰化 / 象牙質 / 再生
Outline of Annual Research Achievements

我々の研究グループでは、象牙質再石灰化に関して強力な石灰化誘導性モノマー(CMET)の開発、修復象牙質形成誘導に関してモノマーに加え、Dentin phosphoproteinを中心とした細胞外マトリックス(合成ペプチド)を利用した象牙質再生材料の開発により、象牙質再石灰化・再生技術を利用して、革新性を有した次世代齲蝕予防・治療法を確立することを目的としている。
2021年度は、Dentin phosphoprotein由来RGD含有合成ペプチド(RGD-1, RGD-3)が象牙芽細胞様細胞株MDPC-23の増殖を促進するとともに、細胞分化マーカーであるALPase活性を促進した。さらにreal time-PCR 法により象牙芽細胞分化マーカーであるDSPP,DMP-1等の遺伝子発現を増強させ、強力な石灰化誘導活性が認められた。このことからRGD-1,RGD-3の強力な象牙芽細胞分化誘導活性が認められた。次に、ラットを用いた直接覆髄実験でRGD-1の象牙質誘導活性について検討した。その結果、従来から直接覆髄材として用いられている水酸化カルシウム製剤と比較して早期に多量の修復象牙質形成を誘導することが明らかになり、歯髄組織への為害作用もなかった。また、象牙芽細胞分化を効率的に獲得するための条件を見出すことを目的として、Hydrogel systemで3D培養を行ったところ、象牙芽細胞分化促進が認められ、臨床応用する際のDDS開発にとって有用なデータであることが示唆された。さらに、CMETを用いたin vitroバイオフィルム形成抑制実験を行い、CMETが根面齲蝕に関連するCandidaによるバイオフィルム形成を抑制することが明らかになった。これらのことからDentin phosphoprotein由来RGD含有ペプチドおよびCMETは多機能性モノマーである可能性が示唆された。

Research Progress Status

令和3年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和3年度が最終年度であるため、記入しない。

Report

(4 results)
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(76 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (10 results) Journal Article (40 results) (of which Int'l Joint Research: 27 results,  Peer Reviewed: 40 results,  Open Access: 32 results) Presentation (24 results) (of which Int'l Joint Research: 9 results,  Invited: 7 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Int'l Joint Research] Stomatol Hospital of Xiamen Med College(中国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Taipei Medical University(その他の国・地域)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Mahidol University(タイ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Tongji University(中国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Mahidol University(タイ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Dhaka Dental College(バングラデシュ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Taipei Medical University(その他の国・地域  台湾)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Taipei Medical University(その他の国・地域)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] City Dental College(バングラデシュ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Illinois at Chicago/Ohio State University(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Three-Dimensional Printing of a Hybrid Bioceramic and Biopolymer Porous Scaffold for Promoting Bone Regeneration Potential2022

    • Author(s)
      Kuo-Sheng Hung , May-Show Chen , Wen-Chien Lan , Yung-Chieh Cho , Takashi Saito , Bai-Hung Huang , Hsin-Yu Tsai , Chia-Chien Hsieh , Keng-Liang Ou , Hung-Yang Lin
    • Journal Title

      Materials

      Volume: 15 Pages: 1971-1971

    • DOI

      10.3390/ma15051971

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Potential of Fluoride-Containing Zinc Oxide and Copper Oxide Nanocomposites on Dentin Bonding Ability2022

    • Author(s)
      Bayarchimeg Altankhishig, Yasuhiro Matsuda, Futami Nagano-Takebe, Katsushi Okuyama, Hiroko Yamamoto, Masahiko Sakurai, Katsuaki Naito, Mikako Hayashi, Hidehiko Sano, Sharanbir K. Sidhu, Takashi Saito
    • Journal Title

      Nanomaterials

      Volume: 12 Pages: 1291-1291

    • DOI

      10.3390/nano12081291

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acceleration Effect of Biomimetic Hydrogel System on Odontoblast Differentiation in Vitro2022

    • Author(s)
      Yaxin Rao, Youjing Qiu, Bayarchimeg Altankhishig, Yasuhiro Matsuda, Yung-Chieh Cho, Bai-Hung Huang, Hsin-Yu Tsai, Chi-Hsun Tsai, Keng-Liang Ou, Takashi Saito
    • Journal Title

      Dentin Pulp Treatment Association Journal

      Volume: 2 Pages: 11-25

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antibacterial activity of zinc oxide and copper oxide nanocomposite2022

    • Author(s)
      Bayarchimeg Altanghishig, Morsheda Khatun, Masahiko Sakurai, Yasuhiro Matsuda, Takashi Saito
    • Journal Title

      Int J Med Sci Dent Res

      Volume: 5 Pages: 57-62

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel Bioactive Adhesive Monomer CMET Promotes Odontogenic Differentiation and Dentin Regeneration2021

    • Author(s)
      Qiu Y, Saito T
    • Journal Title

      Int J Mol Sci

      Volume: 22 Pages: 12728-12728

    • DOI

      10.3390/ijms222312728

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-Biofilm Formation of an Adhesive Containing Calcium Salts of Acidic Monomers against Oral Candida Related to Root Caries2021

    • Author(s)
      Sroisiri Thaweboon, Takashi Saito, Boonyanit Thaweboon
    • Journal Title

      Key Engin Mater

      Volume: 904 Pages: 282-286

    • DOI

      10.4028/www.scientific.net/kem.904.282

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 新規接着性モノマーを配合したグラスアイオノマーセメントの暫間的間接覆髄材への応用2021

    • Author(s)
      佐藤幸平, 藤田裕介, 油井知雄, 尾立達治, 伊藤修一, 斎藤隆史, 川上智史
    • Journal Title

      接着歯学

      Volume: 39 Pages: 47-58

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Potential of a Surface-Modified Titanium Implant with Tetrapeptide for Osseointegration Enhancement2021

    • Author(s)
      Syam Syamsiah、Wu Chia-Jen、Lan Wen-Chien、Ou Keng-Liang、Huang Bai-Hung、Lin Yu-Yeong、Saito Takashi、Tsai Hsin-Yu、Chuo Yen-Chun、Yen Ming-Liang、Liu Chung-Ming、Hou Ping-Jen
    • Journal Title

      Applied Sciences

      Volume: 11 Pages: 2616-2616

    • DOI

      10.3390/app11062616

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Calcium Release from Different Toothpastes after the Incorporation of Tricalcium Phosphate and Amorphous Calcium Phosphate2021

    • Author(s)
      Hou Ping-Jen、Lee Chang-Yu、Ou Keng-Liang、Lan Wen-Chien、Chuo Yen-Chun、Lin Hung-Yang、Chao Hsiao-Wei、Huang Bai-Hung、Saito Takashi、Tsai Hsin-Yu、Yang Tzu-Sen、Walinski Christopher J.、Ruslin Muhammad
    • Journal Title

      Applied Sciences

      Volume: 11 Pages: 1848-1848

    • DOI

      10.3390/app11041848

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 象牙質の再石灰化 / 再生能を有する機能性材料の開発2021

    • Author(s)
      斎藤隆史, 伊藤修一, Youjing Qiu, Jia Tang, 松田康裕
    • Journal Title

      象牙質歯髄治療学会雑誌

      Volume: 1 Pages: 10-16

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dentin Phosphophoryn-Derived Peptide Promotes Odontoblast Differentiation In Vitro and Dentin Regeneration In Vivo2021

    • Author(s)
      Altankhishig Bayarchimeg、Polan Mohammad Ali Akbor、Qiu Youjing、Hasan Md Riasat、Saito Takashi
    • Journal Title

      Materials

      Volume: 14 Pages: 874-874

    • DOI

      10.3390/ma14040874

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The histone deacetylase inhibitor, entinostat (MS-275), induces the odontogenic differentiation of an odontoblast-like cell line in the absence of an osteoblast mineralization medium2021

    • Author(s)
      Sultana Shamima、Uehara Osamu、Yoshida Koki、Saito Takashi、Abiko Yoshihiro
    • Journal Title

      Odontology

      Volume: -

    • DOI

      10.1007/s10266-020-00588-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distribution of elements in teeth and inhibition of demineralization by titanium fluoride: Effects of concentration and pH in a titanium fluoride solution2021

    • Author(s)
      OKUYAMA Katsushi、MATSUDA Yasuhiro、YAMAMOTO Hiroko、SAKURAI Masahiko、NAITO Katsuaki、SHINTANI Kohei、SAITO Takashi、HAYASHI Mikako、TAMAKI Yukimichi
    • Journal Title

      Dental Materials Journal

      Volume: - Pages: 736-742

    • DOI

      10.4012/dmj.2020-193

    • NAID

      130008045400

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Tailored Biomimetic Hydrogel as Potential Bioink to Print a Cell Scaffold for Tissue Engineering Applications: Printability and Cell Viability Evaluation2021

    • Author(s)
      Chen Shyuan-Yow、Cho Yung-Chieh、Yang Tzu-Sen、Ou Keng-Liang、Lan Wen-Chien、Huang Bai-Hung、Saito Takashi、Tsai Chi-Hsun、Peng Bou-Yue、Chuo Yen-Chun、Lin Hung-Yang、Chao Hsiao-Wei、Walinski Christopher J.、Ruslin Muhammad
    • Journal Title

      Applied Sciences

      Volume: 11 Pages: 829-829

    • DOI

      10.3390/app11020829

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of polishing with S-PRG filler-containing paste on enamel remineralization after orthodontic bracket debonding2021

    • Author(s)
      Ryota Nagasaki, Rina Ishikawa, Shuich Ito, Takashi Saito, Masahiro Iijima
    • Journal Title

      Microscopy Research and Technique

      Volume: 84(2) Pages: 171-179

    • DOI

      10.1002/jemt.23575

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human Fresh Fibrin Membrane with Bone Morphogenetic Protein-2 (BMP-2) Induces Bone Formation in the Subcutaneous Tissues of Nude Mice2020

    • Author(s)
      Onji Keiko、Kabir Md. Arafat、Zhu Bowen、Yokozeki Kenji、Saito Takashi、Akazawa Toshiyuki、Murata Masaru
    • Journal Title

      Materials

      Volume: 14 Pages: 150-150

    • DOI

      10.3390/ma14010150

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Potential of a Tailored Biomimetic Hydrogel for In Vitro Cell Culture Applications: Characterization and Biocompatibility2020

    • Author(s)
      Cho Yung-Chieh、Huang Hsiao-Ting、Lan Wen-Chien、Huang Mao-Suan、Saito Takashi、Huang Bai-Hung、Tsai Chi-Hsun、Fan Fang-Yu、Ou Keng-Liang
    • Journal Title

      Applied Sciences

      Volume: 10 Pages: 9035-9035

    • DOI

      10.3390/app10249035

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a Surface-Functionalized Titanium Implant for Promoting Osseointegration: Surface Characteristics, Hemocompatibility, and In Vivo Evaluation2020

    • Author(s)
      Hou Ping-Jen、Syam Syamsiah、Lan Wen-Chien、Ou Keng-Liang、Huang Bai-Hung、Chan Ka-Chun、Tsai Chi-Hsun、Saito Takashi、Liu Chung-Ming、Chou Hsin-Hua、Huang Yueh-Tzu、Fan Fang-Yu
    • Journal Title

      Applied Sciences

      Volume: 10 Pages: 8582-8582

    • DOI

      10.3390/app10238582

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An Innovative Bioceramic Bone Graft Substitute for Bone Defect Treatment: In Vivo Evaluation of Bone Healing2020

    • Author(s)
      Syam Syamsiah、Cho Yung-Chieh、Liu Chung-Ming、Huang Mao-Suan、Lan Wen-Chien、Huang Bai-Hung、Ueno Takaaki、Tsai Chi-Hsun、Saito Takashi、Chen May-Show、Ou Keng-Liang
    • Journal Title

      Applied Sciences

      Volume: 10 Pages: 8303-8303

    • DOI

      10.3390/app10228303

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Accelerated Effect of MatriStem on Dentin Regeneration in Rats2020

    • Author(s)
      Keiko ONJI, Toshiyuki KOIKE, Mohammad Ali Akbor POLAN, Md Riasat HASAN, Bayarchimeg ALTERHISHIG, Yaxin RAO, Youjin QIU, Yasuhiro MATSUDA, Kazuhisa BESSHO, Takashi SAITO
    • Journal Title

      J Oral Tissue Engin

      Volume: 18 Pages: 23-28

    • NAID

      130007927027

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Surface Characteristics and Cell Adhesion Behaviors of the Anodized Biomedical Stainless Steel2020

    • Author(s)
      Hsu Heng-Jui、Wu Chia-Yu、Huang Bai-Hung、Tsai Chi-Hsun、Saito Takashi、Ou Keng-Liang、Chuo Yen-Chun、Lin Kuan-Ling、Peng Pei-Wen
    • Journal Title

      Applied Sciences

      Volume: 10 Pages: 6275-6275

    • DOI

      10.3390/app10186275

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel bio‐active adhesive monomer induces odontoblast differentiation: a comparative study2020

    • Author(s)
      Qiu Y. J.、Tang J.、Saito T.
    • Journal Title

      International Endodontic Journal

      Volume: 53 Pages: 1413-1429

    • DOI

      10.1111/iej.13365

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of an Adhesive Containing Calcium Salt of Acidic Monomers on Inhibition of Biofilm Formation of Bacteria Related to Root Caries2020

    • Author(s)
      Thaweboon Sroisiri、Saito Takashi、Nagano Keiji、Thaweboon Boonyanit
    • Journal Title

      Key Engineering Materials

      Volume: 853 Pages: 41-45

    • DOI

      10.4028/www.scientific.net/kem.853.41

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antimicrobial Effect and Environmental Impact of Controlled Release Iodine Water Disinfectant2020

    • Author(s)
      Matsuda Y., Koshiro K., Fujita M., Saito T,.
    • Journal Title

      International Journal of Pharma Medicine and Biological Sciences

      Volume: 9 Pages: 56-59

    • DOI

      10.18178/ijpmbs.9.2.56-59

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Potential of a Hair Follicle Mesenchymal Stem Cell-Conditioned Medium for Wound Healing and Hair Follicle Regeneration2020

    • Author(s)
      Ou Keng-Liang、Kuo Yun-Wen、Wu Chia-Yu、Huang Bai-Hung、Pai Fang-Tzu、Chou Hsin-Hua、Saito Takashi、Ueno Takaaki、Cho Yung-Chieh、Huang Mao-Suan
    • Journal Title

      Applied Sciences

      Volume: 10 Pages: 2646-2646

    • DOI

      10.3390/app10082646

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film2020

    • Author(s)
      MS. Huang, SY. Yu, PC. Chiang, BH. Huang, T. Saito, CC. Huang, FT. Pai, CY. Wu, WC. Lan
    • Journal Title

      Applied Sciences

      Volume: 10 Pages: 645-645

    • DOI

      10.3390/app10020645

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fabrication of a Promising Hierarchical Porous Surface on Titanium for Promoting Biocompatibility2020

    • Author(s)
      WC. Lan, CH. Wang, BH. Huang, YC. Cho, T. Saito, CC. Huang, MS. Huang
    • Journal Title

      Applied Sciences

      Volume: 10 Pages: 1363-1363

    • DOI

      10.3390/app10041363

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of 4-META/MMA-TBB resin containing calcium chloride dihydrate on dentin remineralization and its mechanical properties2019

    • Author(s)
      NA. Nomann, S. Ito, MR. Hasan, Y. Qiu, T. Saito
    • Journal Title

      J Oral Tissue Engin

      Volume: 17 Pages: 43-52

    • NAID

      130007801609

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antibacterial effect of a fluoride-containing ZnO/CuO nanocomposite2019

    • Author(s)
      Matsuda Y, Okuyama K, Yamamoto H, Fujita M, Abe S, Sato T, Yamada N, Koka M, Sano H, Hayashi M, Sidhu SK, Saito T
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section B

      Volume: 458 Pages: 184-188

    • DOI

      10.1016/j.nimb.2019.06.039

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fluorine distribution from fluoride-releasing luting materials into human dentin2019

    • Author(s)
      Okuyama K, Matsuda Y, Yamamoto H, Tamaki Y, Saito T, Hayashi M, Yoshida Y, Sano H, Sato T, Koka M
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section B

      Volume: 456 Pages: 16-20

    • DOI

      10.1016/j.nimb.2019.06.047

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 15.Dentin Phosphophoryn and its Possibilities in Regenerative Dentistry: A Review2019

    • Author(s)
      T. HASSAN, Y. QIU, J. TANG, T. SAITO
    • Journal Title

      Dent J Health Sci Univ Hokkaido

      Volume: 38 Pages: 9-15

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorine binding with dentin adjacent to fluoride-containing luting materials2019

    • Author(s)
      Okuyama K.、Tamaki Y.、Yamamoto H.、Yagi K.、Hayashi M.、Matsuda Y.、Saito T.、Yasuda K.、Suzuki K.、Sano H.
    • Journal Title

      International Journal of PIXE

      Volume: 27 Pages: 1-9

    • DOI

      10.1142/s0129083518500018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of pastes containing ion-releasing particles on dentin remineralization2019

    • Author(s)
      IIJIMA Masahiro、ISHIKAWA Rina、KAWAGUCHI Kyotaro、ITO Shuichi、SAITO Takashi、MIZOGUCHI Itaru
    • Journal Title

      Dent. Mater. J.

      Volume: 38 Issue: 2 Pages: 271-277

    • DOI

      10.4012/dmj.2018-015

    • NAID

      130007628891

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemical and biological properties of new sealant-use cement materials2019

    • Author(s)
      Kondo Y, Ito S, Uehara O, Kurashige Y, Fujita Y, Saito T, Saitoh M
    • Journal Title

      Dent Mater

      Volume: 35 Pages: 673-685

    • DOI

      10.1016/j.dental.2019.02.014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Micro‐XRD and nanoindentation investigation of bioceramics for dental pulp therapy2019

    • Author(s)
      Alapati SB, Iijima M, Brantley WA, Ito S, Muguruma T, Saito T, Mizoguchi I
    • Journal Title

      Medical Devices & Sensors

      Volume: 2 Pages: 1-7

    • DOI

      10.1002/mds3.10027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elucidation on Predominant Pathways Involved in the Differentiation and Mineralization of Odontoblast-Like Cells by Selective Blockade of Mitogen-Activated Protein Kinases.2018

    • Author(s)
      Tang J, Saito T
    • Journal Title

      BioMed Research International

      Volume: 2018 Pages: 1-10

    • DOI

      10.1155/2018/2370438

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Laminin-1 acts as an adhesive for odontoblast-like cells and promotes their differentiation toward a hard tissue-forming phenotype2018

    • Author(s)
      Tang J, Saito T
    • Journal Title

      J Oral Sci

      Volume: 早期公開 Issue: 2 Pages: 253-261

    • DOI

      10.2334/josnusd.17-0286

    • NAID

      130007398294

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] iMatrix-511 stimulates the proliferation and differentiation of MDPC-23 cells into odontoblast-like phenotype2018

    • Author(s)
      Tang J, Saito T.
    • Journal Title

      J Endod

      Volume: 44 Pages: 1367-1375

    • DOI

      10.1016/j.joen.2018.05.018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The in vitro effects of CCN2 on odontoblast-like cells2018

    • Author(s)
      Qiu Youjing、Tang Jia、Saito Takashi
    • Journal Title

      Arch Oral Biol

      Volume: 94 Pages: 54-61

    • DOI

      10.1016/j.archoralbio.2018.06.017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of Solution Plasma Surface Modification Technology to the Formation of Thin Hydroxyapatite Film on Titanium Implants2018

    • Author(s)
      Akashlynn Badruddoza Dithi, Takashi Nezu, Futami Nagano-Takebe,Takashi Saito, Kazuhiko Endo
    • Journal Title

      Coatings

      Volume: 9 Pages: 1-15

    • DOI

      10.3390/coatings9010003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 次世代齲蝕治療法開発へ向けた象牙質再石灰化・再生技術の展開2021

    • Author(s)
      斎藤隆史
    • Organizer
      日本歯科保存学会2021年度春季学術大会(第154回) 教育講演
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Development of bioactive adhesive materials facilitating dentin remineralization/regeneration2021

    • Author(s)
      Takashi Saito
    • Organizer
      Hokkaido Summer Institute in Hokkaido University
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] フッ化物含有金属複合ナノ粒子による抗菌性の検討2021

    • Author(s)
      松田 康裕, Altankhishig Bayarchimeg, 泉川 昌宣, 油井 知雄, 奥山 克史, 佐野 英彦, 斎藤 隆史
    • Organizer
      日本歯科保存学会2021年度春季学術大会(第154回)
    • Related Report
      2021 Annual Research Report
  • [Presentation] フッ素含有知覚過敏抑制材による抗菌効果の検討2021

    • Author(s)
      松田 康裕, 櫻井 雅彦, 泉川 昌宣, 油井 知雄, 奥山 克史, 佐野 英彦, 斎藤 隆史
    • Organizer
      日本歯科保存学会2021年度春季学術大会(第154回)
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effect of enamel matrix derivative on periodontal tissue regeneration2021

    • Author(s)
      Riasat Hasan, Takashi Saito
    • Organizer
      5th International Conference on Biophysical Technology in Dentistry
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 象牙芽細胞様細胞に対する生体活性型モノマーCMETのin vitro効果の解明:比較研究2020

    • Author(s)
      邱友靖、唐佳、斎藤隆史
    • Organizer
      日本歯科保存学会2020年度春季学術大会(第152回)
    • Related Report
      2020 Annual Research Report
  • [Presentation] フッ素含有知覚過敏抑制材を塗布した歯質中のフッ素分布測定2020

    • Author(s)
      櫻井雅彦、奥山克史、山本洋子、松田康裕、林美加子、斎藤隆史
    • Organizer
      日本歯科保存学会2020年度春季学術大会(第152回)
    • Related Report
      2020 Annual Research Report
  • [Presentation] フッ化チタン処理における各種イオンの歯質への分布と脱灰抑制効果2020

    • Author(s)
      奥山克史、松田康裕、山本洋子、櫻井雅彦、内藤克昭、新谷耕平、斎藤隆史、林美加子
    • Organizer
      日本歯科保存学会2020年度春季学術大会(第152回)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Novel bio-active adhesive monomer CMET stimulates human dental pulp stem cells differentiation toward odontoblast phenotype: a comparative study2020

    • Author(s)
      Youjing Qiu, Takashi Saito
    • Organizer
      The 22nd JSCD/KACD Joint-Scientific Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フッ素含有知覚過敏抑制材を塗布した歯質中のフッ素分布測定2020

    • Author(s)
      松田康裕、櫻井雅彦、奥山克史、山本洋子、佐野英彦、林美加子、斎藤隆史
    • Organizer
      日本歯科保存学会2020年度秋季学術大会(第153回)
    • Related Report
      2020 Annual Research Report
  • [Presentation] グラスアイオノマーセメントによるマトリックスメタロプロテアーゼ抑制2020

    • Author(s)
      櫻井雅彦、松田康裕、泉川昌宣、佐野英彦、斎藤隆史
    • Organizer
      日本歯科保存学会2020年度秋季学術大会(第153回)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 直接覆髄剤として使用される生体活性型接着性モノマーのin vitro及び、in vivo効果2020

    • Author(s)
      邱友靖、斎藤隆史
    • Organizer
      第18回日本再生歯科医学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ZnO/CuOナノコンポジットによるマトリックスメタロプロテアーゼ抑制2020

    • Author(s)
      Bayarchimeg Altankhishig, Yasuhiro Matsuda, Youjing Qiu, Takashi Saito
    • Organizer
      第18回日本再生歯科医学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Er:YAGレーザーによる象牙質切削時の照射角度と切削効率に関する基礎的研究2019

    • Author(s)
      泉川昌宣,猪熊孝憲,斎藤隆史
    • Organizer
      第31回日本レーザー歯学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] レーザーチップの清掃方法に関する検討2019

    • Author(s)
      猪熊孝憲,泉川昌宣,松田康裕,櫻井雅彦,伊藤修一,斎藤隆史
    • Organizer
      第150回日本歯科保存学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Antimicrobial effect and environmental impact of controlled release iodine water disinfectant2019

    • Author(s)
      Yasuhiro Matsuda, Kenichi Koshiro, Mari Fujita and Takashi Saito
    • Organizer
      7th International Conference on Sustainable Environment and Agriculture
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体活性型接着性モノマーCMETは象牙芽細胞分化を誘導する2019

    • Author(s)
      邱 友靖,松田 康裕,斎藤 隆史
    • Organizer
      第151回日本歯科保存学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] フッ化物含有金属複合ナノ粒子が象牙質接着性能に及ぼす影響2019

    • Author(s)
      Bayarchimeg Altenkhishig, 建部二三,松田康裕,奥山克史,山本洋子,Mosammat Morsheda Khatun, 泉川真宣,斎藤隆史
    • Organizer
      第150回日本歯科保存学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 口腔衛生状態を評価する新規スクリーニングシステムの開発2019

    • Author(s)
      Mosammat Morsheda Khatun,,松田康裕,奥山克史,山本洋子,Bayarchimeg Altenkhishig, 泉川真宣,斎藤隆史
    • Organizer
      第150回日本歯科保存学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Micro-tensile Bond Strength Test of self-etching bond with fluoride-containing Zinc and Copper nanocomposite2019

    • Author(s)
      Bayarchimeg Altankhishig, Yasuhiro Matsuda, Katsushi Okuyama, Hiroko Yamamoto, Khatun Mosammat Morsheda, Masanobu Izumikawa, Takashi Saito
    • Organizer
      2019 International Symposium of Taiwan Society of Blood Biomaterials
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Strategy for Caries Treatment -Towards Establishment of Dentin Remineralization/ Regeneration Therapy-2019

    • Author(s)
      Takashi Saito
    • Organizer
      2019 International Symposium of Taiwan Society of Blood Biomaterials
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel Strategy for Caries Treatment-Development of Dentin Remineralization/ Regeneration Therapy-2018

    • Author(s)
      Takashi Saito
    • Organizer
      UiTM Special Seminar
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New Concept of Dentin Re-mineralization in Adhesive Dentistry2018

    • Author(s)
      Takashi Saito
    • Organizer
      13th International Dental Collaboration of the Mekong River Region
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel Strategy for Caries Treatment-Development of Dentin Remineralization/ Regeneration Therapy-2018

    • Author(s)
      Takashi Saito
    • Organizer
      Chulalongkorn University Special Lecture
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Patent(Industrial Property Rights)] 象牙芽細胞増殖・分化促進剤2021

    • Inventor(s)
      斎藤隆史, 邱友靖ら
    • Industrial Property Rights Holder
      サンメディカル
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] PHARMACEUTICAL COMPOSITION INCLUDING LAMININ FRAGMENTS TO TREAT OR PREVENT THE DISEASE, DISORDER OR SYMPTOM OF TOOTH DENTIN AND/OR DENTAL PULP2020

    • Inventor(s)
      Jia Tang, Takashi Saito
    • Industrial Property Rights Holder
      Jia Tang, Takashi Saito
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
    • Overseas

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Published: 2018-04-23   Modified: 2022-12-28  

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