• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of spatial and time specific physio therapy using broad dielectric spectroscopy

Research Project

Project/Area Number 18H03128
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionKyoto University

Principal Investigator

Aoyama Tomoki  京都大学, 医学研究科, 教授 (90378886)

Co-Investigator(Kenkyū-buntansha) 新屋敷 直木  東海大学, 理学部, 教授 (00266363)
池口 良輔  京都大学, 医学研究科, 准教授 (80437201)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords物理療法 / 電気刺激 / 神経再生 / aaaa / 物理治療 / 定位的 / 広帯域誘電法
Outline of Final Research Achievements

On peripheral injury, the protein and water contents changes in each regeneration steps. It means that physical phenomenon in each steps are differed when electrically stimulated. But current electrical stimulation condition is provided in same condition. The broad dielectric spectroscopy is a high through put screening device using impedance method for measuring the electrical response when electric stimulation broadly. The purpose of the study is to find a suitable electrical stimulation condition in each steps of nerve regeneration using the broad dielectric spectroscopy.

Academic Significance and Societal Importance of the Research Achievements

これまで電気治療をはじめとする物理療法は、教科書に記載されているような組織深度を基準に、経験的にその刺激条件の検証が行われてきた。治癒を促す組織の再生の程度や時期によって、その条件は変化するものであるが、そのような視点ではこれまで検証されてこなかった。すなわち今回のテーマである末梢神経障害の病態に沿って検証された結果ではないことから良好とは言えない臨床結果を示している。本申請においては細胞や組織を、水分子含んだタンパク集合体と捉え、そのタンパク集合体の時期、組成に応じた刺激条件を検証するといった手法であり、病理的なロジックモデルに即した再生促進条件を検証するものである。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (16 results)

All 2021 2019 2018

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 6 results) Presentation (8 results) (of which Int'l Joint Research: 8 results,  Invited: 1 results)

  • [Journal Article] Interfacial polarization of in vivo rat sciatic nerve with crush injury studied via broadband dielectric spectroscopy.2021

    • Author(s)
      Otagiri R, Kawai H, Takatsuka M, Shinyashiki N, Ito A, Ikeguchi R, Aoyama T.
    • Journal Title

      Plos One

      Volume: 16 Issue: 6 Pages: e0252589-e0252589

    • DOI

      10.1371/journal.pone.0252589

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relative antigenicity of components in vascularized composite allotransplants: An experimental study of microRNAs expression in rat hind limb transplantation model.2019

    • Author(s)
      Oda H, Ikeguchi R, Aoyama T, Ohta S, Noguchi T, Kaizawa Y, Yurie H, Takeuchi H, Mitsuzawa S, Yamamoto K, Matsuda S.
    • Journal Title

      Microsurgery

      Volume: 39 Issue: 4 Pages: 340-348

    • DOI

      10.1002/micr.30408

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The efficacy of a scaffold-free bio 3D conduit developed from autologous dermal fibroblasts on peripheral nerve regeneration in a canine ulnar nerve injury model: A preclinical proof-of-concept study2019

    • Author(s)
      Mitsuzawa S, Ikeguchi R, Aoyama T, Takeuchi H, Yurie H, Oda H, Ohta S, Ushimaru M, Ito T, Tanaka M, Kunitomi Y, Tsuji M, Akieda S, Nakayama K, Matsuda S.
    • Journal Title

      Cell Transplant

      Volume: 28 Issue: 9-10 Pages: 1231-1241

    • DOI

      10.1177/0963689719855346

    • NAID

      120006951683

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induced pluripotent stem cell-derived mesenchymal stem cells prolong hind limb survival in a rat vascularized composite allotransplantation model.2019

    • Author(s)
      Mitsuzawa S, Ikeguchi R, Aoyama T, Ando M, Takeuchi H, Yurie H, Oda H, Noguchi T, Ohta S, Zhao C, Ikeya M, Matsuda S
    • Journal Title

      Microsurgery

      Volume: 20 Issue: 8 Pages: 737-747

    • DOI

      10.1002/micr.30507

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute Effects of Capacitive and Resistive Electric Transfer (CRet) on the Achilles Tendon2019

    • Author(s)
      Bito T, Tashiro Y, Suzuki Y, Kajiwara Y, Zeidan H, Kawagoe M, Sonoda T, Nakayama Y, Yokota Y, Shimoura K, Tatsumi M, Nakai K, Nishida Y, Yoshimi S, Tsuboyama T, Aoyama T.
    • Journal Title

      Electromagn Biol Med

      Volume: 38 Issue: 2 Pages: 48-54

    • DOI

      10.1080/15368378.2020.1737803

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute effects of capacitive and resistive electric transfer (CRet) on the achilles tendon.2019

    • Author(s)
      Bito T, Tashiro Y, Suzuki Y, Kajiwara Y, Zeidan H, Kawagoe M, Sonoda T, Nakayama Y, Yokota Y, Shimoura K, Tatsumi M, Nakai K, Nishida Y, Yoshimi S, Tsuboyama T, Aoyama T.
    • Journal Title

      Electromagn Biol Med

      Volume: 38(1) Issue: 1 Pages: 48-54

    • DOI

      10.1080/15368378.2019.1567525

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional evaluation outcomes correlate with histomorphometric changes in the rat sciatic nerve crush injury model: A comparison between sciatic functional index and kinematic analysis2018

    • Author(s)
      Wang Tianshu、Ito Akira、Aoyama Tomoki、Nakahara Ryo、Nakahata Akihiro、Ji Xiang、Zhang Jue、Kawai Hideki、Kuroki Hiroshi
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 12 Pages: 1-9

    • DOI

      10.1371/journal.pone.0208985

    • NAID

      120006546016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional motion analysis for comprehensive understanding of gait characteristics after sciatic nerve lesion in rodents2018

    • Author(s)
      Tajino Junichi、Ito Akira、Tanima Momoko、Yamaguchi Shoki、Iijima Hirotaka、Nakahata Akihiro、Kiyan Wataru、Aoyama Tomoki、Kuroki Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-018-31579-z

    • NAID

      120006529728

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Kinematic analysis for understanding functional changes over time and correlations between functional and histomorphometric data following sciatic nerve crush injury in rats2019

    • Author(s)
      Tianshu Wang, Akira Ito, Ryo Nakahara, Akihiro Nakahata, Xiang Ji, Jue Zhang, Hideki Kawai, Naoko Kubo, Hiroshi Kuroki, Tomoki Aoyama
    • Organizer
      13th International Society of Physical and Rehabilitation Medicine World Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Immediate Effects of Transcutaneous Electrical Nerve Stimulation on Pain and Physical Performance during Physical Functional Tests in Individuals with Pre-Radiographic Knee Osteoarthritis.2019

    • Author(s)
      Kanako Shimoura, Hirotaka Iijima, Yusuke Suzuki, Tomoki Aoyama
    • Organizer
      13th International Society of Physical and Rehabilitation Medicine World Congress.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Efficacy of a scaffold-free bio 3D conduit on peripheral nerve regeneration.2018

    • Author(s)
      Aoyama T
    • Organizer
      5th TERMIS World Cogress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The efficacy of a scaffold free Bio 3D conduit developed from dermal fibroblasts on peripheral nerve injury in a canine ulnar nerve injury model.2018

    • Author(s)
      Mitsuzawa S,Ikeguchi R, Aoyama T, Takeuchi H, Yurie H, Oda H, Ohta S, Tsuji M, Akieda S, Nakayama K, Matsuda S.
    • Organizer
      5th TERMIS World Cogress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Peripheral nerve regeneration using a bio 3D conduit from undifferentiated bone marrow stromal cells2018

    • Author(s)
      Hirofumi Yurie, Ryosuke Ikeguchi, Tomoki Aoyama, Souichi Ohta, Koichi Nakayama, Shuichi Matsuda.
    • Organizer
      ASSH 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ultrasound therapy suppresses inflammatory gene expression in an injured peripheral nerve after sciatic nerve crush injury in rats.2018

    • Author(s)
      Akira Ito, Tianshu Wang, Ryo Nakahara, Hideki Kawai, Akihiro Nakahata, Jue Zhang, Naoko Kubo, Junichi Tajino, Tomoki Aoyama, Hiroshi Kuroki. Ultrasound therapy suppresses inflammatory gene expression in an injured peripheral nerve after sciatic nerve crush injury in rats.
    • Organizer
      7th International Symposium on Regenerative Rehabilitation
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effectiveness of rehabilitation after cell transplantation for peripheral nerve regeneration: protocol for a systematic review.2018

    • Author(s)
      Hideki Kawai, Akira Ito, Tomoki Aoyama, Hiroshi Kuroki
    • Organizer
      7th International Symposium on Regenerative Rehabilitation
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The correlation of kinematic changes with histomorphometric data in the rat sciatic nerve crush injury model.2018

    • Author(s)
      Tianshu Wang, Akira Ito, Ryo Nakahara, Akihiro Nakahata, Xiang Ji, Jue Zhang, Hideki Kawai, Naoko Kubo, Hiroshi Kuroki, Tomoki Aoyama.
    • Organizer
      7th International Symposium on Regenerative Rehabilitation
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi