| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
In this study, we addressed whether reduction of Prdm13 function in the dorsomedial hypothalamus causes a deficit in thermoregulation before sleep onset, resulting in sleep problems. Mouse studies using old mice, dietary restricted mice, and dorsomedial hypothalamic-specific Prdm13-knockout mice revealed that changes in body temperature at the onset of sleep is highly correlated with changes in sleep regulatory network. We also observed there is a sexual dimorphism in this regulation.
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