Development of novel water infrastructure able to control human norovirus prevalence
Project/Area Number |
18H03792
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Medium-sized Section 22:Civil engineering and related fields
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Research Institution | Tohoku University |
Principal Investigator |
Omura Tatsuo 東北大学, 未来科学技術共同研究センター, 名誉教授 (30111248)
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Co-Investigator(Kenkyū-buntansha) |
片山 浩之 東京大学, 大学院工学系研究科(工学部), 教授 (00302779)
渡部 徹 山形大学, 農学部, 教授 (10302192)
李 玉友 東北大学, 工学研究科, 教授 (30201106)
渡辺 幸三 愛媛大学, 沿岸環境科学研究センター, 教授 (80634435)
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Project Period (FY) |
2018-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥44,460,000 (Direct Cost: ¥34,200,000、Indirect Cost: ¥10,260,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2019: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2018: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
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Keywords | ノロウイルス / 水インフラ / 消毒剤耐性 / 進化 / 消毒剤耐 / 次世代シーケンス / マウスノロウイルス / 消毒 / 除去 |
Outline of Final Research Achievements |
In mouse noroviruses used as surrogate model viruses for human noroviruses, we found that disinfection with free chlorine and alkaline treatment caused adaptive evolution in which the mouse norovirus population acquired disinfection resistance. These results suggest that the use of virus strains with higher susceptibility to disinfection (i.e., lower disinfection resistance) in disinfection tests performed in sewage treatment is likely to introduce bias in the assessment of viral strain inactivation efficiency. This finding indicates the need to use less susceptible virus strains in disinfection testing.
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Academic Significance and Societal Importance of the Research Achievements |
下水処理場はヒトを感染症から守る重要な水インフラであるが、下水処理過程で行われる消毒処理が、ノロウイルス等の病原体への消毒耐性を獲得させる進化圧となっている可能性がある。本研究は、培養細胞を使った実験室レベルのウイルス進化実験を行い、水インフラ環境に起因する病原体の適応進化を示す証拠を示した。この知見は、下水処理により除去/不活化されにくいノロウイルスの遺伝系統を見極め、それらを不活化するために十分な消毒剤の添加量を定めるための基礎的知見として活用される。
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Weekly Variation of Rotavirus A Concentrations in Sewage and Oysters in Japan, 2014-20162019
Author(s)
Ito, E., J. Pu, T. Miura, S. Kazama, M. Nishiyama, H. Ito, Y. Konta, G. T. Nguyen, T. Omura, T. Watanabe
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Journal Title
Pathogens
Volume: 8
Issue: 3
Pages: 89-89
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A Genetic Determinant of Norovirus for Susceptibility to Free Chlorine2018
Author(s)
Andri Rachmadi, Masaaki Kitajima, Kozo Watanabe, Sakiko Yaegashi, Joeselle Serrana, Arata Nakamura, Toyoko Nakagomi, Osamu Nakagomi, Kazuhiko Kazuhiko Katayama, Satoshi Okabe, and Daisuke Sano
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Journal Title
Applied and Environmental Microbiology
Volume: 印刷中
Issue: 13
DOI
Related Report
Peer Reviewed / Open Access
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